Thrombosis diagnostic evaluation

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Associate Editors-in-Chief: Ujjwal Rastogi, MBBS [2]

Diagnostic evaluation

cDNA-PCR assays for gene mutations and polymorphisms:

• 4G/5G polymorphism of the plasminogen activator inhibitor-1 gene (PAI-1)
• Cystathionine beta synthetase (CBS) CBS T833C & G919A
• Factor V Leiden
• Glycoprotein IIIa A1/A2 (platelet glycoprotein)
• Methylenetetrahydrofolate reductase (MTHFR) MTHFR C677T
• Prothrombin G20210A

Serologic (blood) tests:

• Anticardiolipin antibodies (ACLA) IgG and IgM ACLA
• Antithrombin III
• Factor VIII
• Homocysteine
• Lupus anticoagulant (LA)
• Proteins C
• Protein S

Evaluation of hypofibrinolysis

• 4G/5G polymorphism of the plasminogen activator inhibitor-1 gene (PAI-1)(requires cDNA-PCR assay for gene mutation)
• Lipoprotein a Lp(a)