Microscopic polyangiitis

Microscopic polyangiitis
ICD-10	M31.7
DiseasesDB	8193

WikiDoc Resources for Microscopic polyangiitis
Articles
Most recent articles on Microscopic polyangiitis Most cited articles on Microscopic polyangiitis Review articles on Microscopic polyangiitis Articles on Microscopic polyangiitis in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Microscopic polyangiitis Images of Microscopic polyangiitis Photos of Microscopic polyangiitis Podcasts & MP3s on Microscopic polyangiitis Videos on Microscopic polyangiitis
Evidence Based Medicine
Cochrane Collaboration on Microscopic polyangiitis Bandolier on Microscopic polyangiitis TRIP on Microscopic polyangiitis
Clinical Trials
Ongoing Trials on Microscopic polyangiitis at Clinical Trials.gov Trial results on Microscopic polyangiitis Clinical Trials on Microscopic polyangiitis at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Microscopic polyangiitis NICE Guidance on Microscopic polyangiitis NHS PRODIGY Guidance FDA on Microscopic polyangiitis CDC on Microscopic polyangiitis
Books
Books on Microscopic polyangiitis
News
Microscopic polyangiitis in the news Be alerted to news on Microscopic polyangiitis News trends on Microscopic polyangiitis
Commentary
Blogs on Microscopic polyangiitis
Definitions
Definitions of Microscopic polyangiitis
Patient Resources / Community
Patient resources on Microscopic polyangiitis Discussion groups on Microscopic polyangiitis Patient Handouts on Microscopic polyangiitis Directions to Hospitals Treating Microscopic polyangiitis Risk calculators and risk factors for Microscopic polyangiitis
Healthcare Provider Resources
Symptoms of Microscopic polyangiitis Causes & Risk Factors for Microscopic polyangiitis Diagnostic studies for Microscopic polyangiitis Treatment of Microscopic polyangiitis
Continuing Medical Education (CME)
CME Programs on Microscopic polyangiitis
International
Microscopic polyangiitis en Espanol Microscopic polyangiitis en Francais
Business
Microscopic polyangiitis in the Marketplace Patents on Microscopic polyangiitis
Experimental / Informatics
List of terms related to Microscopic polyangiitis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]

Overview

Microscopic polyangiitis (MPA) is an ill-defined autoimmune disease characterized by pauci-immune, necrotizing, small-vessel vasculitis without clinical or pathological evidence of necrotizing granulomatous inflammation. Because many different organ systems may be involved, a wide range of symptoms are possible in MPA.

Diagnosis

Laboratory tests show an increased sedimentation rate, reduced red blood count, antineutrophil cytoplasmic antibodies (p-ANCA) directed against [MPO(a constituent of neutrophil granules), and protein and red blood cells in the urine.

The test for anti-glomerular basement membrane antibody (GBM), which is positive in Goodpasture's syndrome, is negative.

Cause

This condition, the clinical picture of which may include many features of systemic lupus erythematosis, has been reported to have been caused by antibiotics and also by certain infections, though, as with many autoimmune diseases, the causes remain to a large extent unknown.

Treatment

The customary treatment involves long term dosage of prednisone, alternated or combined with cytotoxic drugs, such as cyclophosphamide or azathioprine. Plasmapheresis may also be indicated in the acute setting to remove ANCA antibodies.

See also

• ANCA-associated vasculitides
• Polyarteritis nodosa

External links

Overview from Johns Hopkins

Template:Diseases of the musculoskeletal system and connective tissue de:Mikroskopische Polyangiitis nl:Microscopische polyangiitis

Template:WikiDoc Sources