Thrombosis causes: Difference between revisions

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Revision as of 18:10, 30 August 2011

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editors-in-Chief: Ujjwal Rastogi, MBBS [2]

Etiology

Rudolf Virchow noted several factors affecting the clot formation, which are:

1).Alterations in blood flow (stasis) : Normally the blood flow throughout the circulatory system, without significantly stopping or slowing any where. In certain pathological conditions where the blood flow slows down or stops, which causes

a) Increases platelet/endothelium contact
b) Decrease the dilution of clotting factors

This increases the risk of clot formation and form microthrombi, which further grow and propagate.

2).Injury to the vascular endothelium : Intrinsic or secondary to external trauma(for example in catheterization) can cause intimal damage and can stimulate the clot formation.

3).Alterations in the constitution of blood (hypercoagulability) :This lead to the tendency to develop blood clots(Thrombosis).

These three conditions are collectively known as Virchow's triad.

High altitude has also been known to induce thrombosis ^[1]. Occasionally, abnormalities in coagulation are to blame.

Intravascular coagulation follows, forming a structureless mass of red blood cells, leukocytes, and fibrin.

References

↑ Kuipers S, Cannegieter SC, Middeldorp S, Robyn L, Büller HR, Rosendaal FR (2007). "The absolute risk of venous thrombosis after air travel: a cohort study of 8,755 employees of international organisations". PLoS Med. 4 (9): e290. doi:10.1371/journal.pmed.0040290. PMC 1989755. PMID 17896862.

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cs:Trombóza de:Thrombose eo:Trombozo it:Trombosi he:תרומבוס ms:Trombotik nl:Trombose fi:Verihiutale

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[pmid17896862-1] Kuipers S, Cannegieter SC, Middeldorp S, Robyn L, Büller HR, Rosendaal FR (2007). "The absolute risk of venous thrombosis after air travel: a cohort study of 8,755 employees of international organisations". PLoS Med. 4 (9): e290. doi:10.1371/journal.pmed.0040290. PMC 1989755. PMID 17896862.

[1]

@@ Line 4: / Line 4: @@
 ==Etiology==
-Classically, thrombosis is caused by abnormalities in one or more of the following ([[Rudolf Virchow|Virchow]]'s triad):
+[[Rudolf Virchow]] noted several factors affecting the clot formation, which are:
-* The composition of the blood (hypercoagulability)
-* Quality of the vessel wall (endothelial cell injury)
-* Nature of the blood flow (hemostasis)
-The formation of a thrombus is usually caused by the top three causes, known as Virchow's triad.  To elaborate, the pathogenesis includes:
+'''1).Alterations in blood flow ([[stasis]])''' : Normally the blood flow throughout the circulatory system, without significantly stopping or slowing any where. In certain pathological conditions where the blood flow slows down or stops, which causes
-* an injury to the vessel's wall (such as by trauma, infection, or turbulent flow at bifurcations)
+*a) Increases platelet/endothelium contact
-* by the slowing or stagnation of blood flow past the point of injury (which may occur after long periods of sendentary behavior -  for example, sitting on a long airplane flight
+*b) Decrease the dilution of clotting factors
-* by a blood state of hypercoagulability (caused for example, by genetic deficiencies or autoimmune disorders).
+This increases the risk of clot formation and form microthrombi, which further grow and propagate.
+'''2).Injury to the vascular endothelium''' : Intrinsic or secondary to external trauma(for example in catheterization) can cause [[Tunica intima|intimal]] damage and can stimulate the clot formation.
+'''3).Alterations in the constitution of blood ([[hypercoagulability]])''' :This lead to the tendency to develop blood clots([[Thrombosis]]).
+These three conditions are collectively known as [[Virchow's triad]].
 High altitude has also been known to induce thrombosis <ref name="pmid17896862">{{cite journal| author=Kuipers S, Cannegieter SC, Middeldorp S, Robyn L, Büller HR, Rosendaal FR| title=The absolute risk of venous thrombosis after air travel: a cohort study of 8,755 employees of international organisations. | journal=PLoS Med | year= 2007 | volume= 4 | issue= 9 | pages= e290 | pmid=17896862 | doi=10.1371/journal.pmed.0040290 | pmc=PMC1989755 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17896862  }} </ref>.  Occasionally, abnormalities in [[coagulation]] are to blame.

Thrombosis causes: Difference between revisions

Revision as of 18:10, 30 August 2011

Etiology

References

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