Thrombosis causes: Difference between revisions
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'''2).Injury to the vascular endothelium''' : Intrinsic or secondary to external trauma (Eg. catheterization) can cause [[Tunica intima|intimal]] damage and stimulates clot formation. See [[Coagulation]] | '''2).Injury to the vascular endothelium''' : Intrinsic or secondary to external trauma (Eg. catheterization) can cause [[Tunica intima|intimal]] damage and stimulates clot formation. See [[Coagulation]] | ||
'''3).Alterations in the constitution of blood ([[hypercoagulability]])''' :This lead to the tendency to develop blood clots | '''3).Alterations in the constitution of blood ([[hypercoagulability]])''' :This lead to the tendency to develop blood clots. | ||
These three conditions are collectively known as [[Virchow's triad]]. | These three conditions are collectively known as [[Virchow's triad]]. This lead to intravascular [[coagulation]], forming a structureless mass of [[red blood cell]]s, [[leukocyte]]s, and [[fibrin]]. | ||
High altitude has also been known to induce thrombosis <ref name="pmid17896862">{{cite journal| author=Kuipers S, Cannegieter SC, Middeldorp S, Robyn L, Büller HR, Rosendaal FR| title=The absolute risk of venous thrombosis after air travel: a cohort study of 8,755 employees of international organisations. | journal=PLoS Med | year= 2007 | volume= 4 | issue= 9 | pages= e290 | pmid=17896862 | doi=10.1371/journal.pmed.0040290 | pmc=PMC1989755 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17896862 }} </ref>. Occasionally, abnormalities in [[coagulation]] are to blame. | High altitude has also been known to induce thrombosis <ref name="pmid17896862">{{cite journal| author=Kuipers S, Cannegieter SC, Middeldorp S, Robyn L, Büller HR, Rosendaal FR| title=The absolute risk of venous thrombosis after air travel: a cohort study of 8,755 employees of international organisations. | journal=PLoS Med | year= 2007 | volume= 4 | issue= 9 | pages= e290 | pmid=17896862 | doi=10.1371/journal.pmed.0040290 | pmc=PMC1989755 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17896862 }} </ref>. Occasionally, abnormalities in [[coagulation]] are to blame. | ||
Revision as of 21:12, 3 September 2011
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Thrombosis Microchapters |
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Site of Thrombosis |
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Differentiating Thrombosis from other Diseases |
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Thrombosis causes On the Web |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editors-in-Chief: Ujjwal Rastogi, MBBS [2]
Overview
Rudolf Virchow noted several factors affecting the clot formation, which are:
1).Alterations in blood flow (stasis) : Blood flows throughout the circulatory system, without significantly stopping or slowing any where. In certain pathological conditions where the blood flow slows down or stops, it causes
- a) Increase in platelet to endothelium contact
- b) Decrease the dilution of clotting factors
This increases the risk of clot formation and form microthrombi, which further grow and propagate.
2).Injury to the vascular endothelium : Intrinsic or secondary to external trauma (Eg. catheterization) can cause intimal damage and stimulates clot formation. See Coagulation
3).Alterations in the constitution of blood (hypercoagulability) :This lead to the tendency to develop blood clots.
These three conditions are collectively known as Virchow's triad. This lead to intravascular coagulation, forming a structureless mass of red blood cells, leukocytes, and fibrin.
High altitude has also been known to induce thrombosis [1]. Occasionally, abnormalities in coagulation are to blame.
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References
- ↑ Kuipers S, Cannegieter SC, Middeldorp S, Robyn L, Büller HR, Rosendaal FR (2007). "The absolute risk of venous thrombosis after air travel: a cohort study of 8,755 employees of international organisations". PLoS Med. 4 (9): e290. doi:10.1371/journal.pmed.0040290. PMC 1989755. PMID 17896862.
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