Rheumatic fever laboratory tests: Difference between revisions
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*[[Throat culture]] for group A beta hemolytic streptococci may be performed. However many patients may have negative culture by the time rheumatic fever develops<ref name="pmid1404745">{{cite journal| author=| title=Guidelines for the diagnosis of rheumatic fever. Jones Criteria, 1992 update. Special Writing Group of the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young of the American Heart Association. | journal=JAMA | year= 1992 | volume= 268 | issue= 15 | pages= 2069-73 | pmid=1404745 | doi= | pmc= | url= }} </ref>. | *[[Throat culture]] for group A beta hemolytic streptococci may be performed. However many patients may have negative culture by the time rheumatic fever develops<ref name="pmid1404745">{{cite journal| author=| title=Guidelines for the diagnosis of rheumatic fever. Jones Criteria, 1992 update. Special Writing Group of the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young of the American Heart Association. | journal=JAMA | year= 1992 | volume= 268 | issue= 15 | pages= 2069-73 | pmid=1404745 | doi= | pmc= | url= }} </ref>. | ||
*Rapid streptococcal antigen test is quicker. However, it has a lower sensitivity (70%) and statistically equal specificity (98%) as throat culture<ref name="pmid19275067">{{cite journal| author=Choby BA| title=Diagnosis and treatment of streptococcal pharyngitis. | journal=Am Fam Physician | year= 2009 | volume= 79 | issue= 5 | pages= 383-90 | pmid=19275067 | doi= | pmc= | url= }} </ref>. Therefore, negative test results rules out streptococcal infection. | *Rapid streptococcal antigen test is quicker. However, it has a lower sensitivity (70%) and statistically equal specificity (98%) as throat culture<ref name="pmid19275067">{{cite journal| author=Choby BA| title=Diagnosis and treatment of streptococcal pharyngitis. | journal=Am Fam Physician | year= 2009 | volume= 79 | issue= 5 | pages= 383-90 | pmid=19275067 | doi= | pmc= | url= }} </ref>. Therefore, negative test results rules out streptococcal infection. | ||
*Elevated or rising [[antistreptolysin O]] antibody titer. | *Elevated or rising [[antistreptolysin O]] antibody titer is often noted. The antibodies usually peak approximately during fourth or fifth week after the onset of infection. Patients should be tested at intervals of two weeks to detect raising titers. [[Antistreptococcal antibodies]] may also be noted in patients who are steptococcal carriers with asymptomatic pharyngitis. | ||
==References== | ==References== | ||
Revision as of 21:10, 16 September 2011
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Varun Kumar, M.B.B.S.
Inflammatory Markers
The following inflammatory markers are often elevated:
- CBC: Leukocytosis
- C-reactive protein
- Erythrocyte sedimentation rate (ESR)
Diagnosis of Streptococcus Pharyngitis
- Throat culture for group A beta hemolytic streptococci may be performed. However many patients may have negative culture by the time rheumatic fever develops[1].
- Rapid streptococcal antigen test is quicker. However, it has a lower sensitivity (70%) and statistically equal specificity (98%) as throat culture[2]. Therefore, negative test results rules out streptococcal infection.
- Elevated or rising antistreptolysin O antibody titer is often noted. The antibodies usually peak approximately during fourth or fifth week after the onset of infection. Patients should be tested at intervals of two weeks to detect raising titers. Antistreptococcal antibodies may also be noted in patients who are steptococcal carriers with asymptomatic pharyngitis.
References
- ↑ "Guidelines for the diagnosis of rheumatic fever. Jones Criteria, 1992 update. Special Writing Group of the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young of the American Heart Association". JAMA. 268 (15): 2069–73. 1992. PMID 1404745.
- ↑ Choby BA (2009). "Diagnosis and treatment of streptococcal pharyngitis". Am Fam Physician. 79 (5): 383–90. PMID 19275067.