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{{Drugbox|
__NOTOC__
|IUPAC_name =
{{Niclosamide}}
| image = Niclosamide.png
{{CMG}}
| CAS_number=50-65-7
 
| ATC_prefix=P02
==Overview==
| ATC_suffix=DA01
 
| ATC_supplemental=
| PubChem=4477
| DrugBank=
| C=13 | H=8 | Cl=2 | N=2 | O=4
| molecular_weight = 327.119 g/mol
| bioavailability=
| metabolism =
| elimination_half-life=
| excretion =
| pregnancy_category =  
| legal_status =  
| routes_of_administration=  
}}
'''Niclosamide''' (trade name '''Niclocide''') is a [[teniacide]] ("tenia-" referring to [[tapeworm]]) in the [[anthelmintic]] family  especially effective against [[cestodes]] that infect humans. It is also used as a [[piscicide]].
'''Niclosamide''' (trade name '''Niclocide''') is a [[teniacide]] ("tenia-" referring to [[tapeworm]]) in the [[anthelmintic]] family  especially effective against [[cestodes]] that infect humans. It is also used as a [[piscicide]].


It is stressed that while anthelmintics are a drug familiy used to treat worm infections, Niclosamide is used specifically to treat [[tapeworms]] and is not effective against worms such as [[pinworms]] or [[roundworms]].  
It is stressed that while anthelmintics are a drug familiy used to treat worm infections, Niclosamide is used specifically to treat [[tapeworms]] and is not effective against worms such as [[pinworms]] or [[roundworms]].
 
It is a chewable tablet taken orally, dosage depending on type of worm and patient's age and/or weight.
 
Niclosamide molecules are lethal to tapeworms upon contact.


It is a chewable tablet taken orally, dosage depending on type of worm and patient's age and/or weight.
==Category==


Niclosamide molecules are lethal to tapeworms upon contact.
Anthelmintic


== Side effects ==
==US Brand Names==


The medication can have side effects such as abdominal pain, anorexia, diarrhea, and emesis.  Rarely, dizziness, skin rash, drowsiness, perianal itching, and an unpleasant taste.
NICLOCIDE, YOMESAN (DISCONTINUED)


== Mechanism of action ==
==FDA Package Insert==


'''  [[Niclosamide description|Description]]'''
'''| [[Niclosamide clinical pharmacology|Clinical Pharmacology]]'''
'''| [[Niclosamide microbiology|Microbiology]]'''
'''| [[Niclosamide indications and usage|Indications and Usage]]'''
'''| [[Niclosamide contraindications|Contraindications]]'''
'''| [[Niclosamide warnings and precautions|Warnings and Precautions]]'''
'''| [[Niclosamide adverse reactions|Adverse Reactions]]'''
'''| [[Niclosamide drug interactions|Drug Interactions]]'''
'''| [[Niclosamide overdosage|Overdosage]]'''
'''| [[Niclosamide clinical studies|Clinical Studies]]'''
'''| [[Niclosamide dosage and administration|Dosage and Administration]]'''
'''| [[Niclosamide how supplied|How Supplied]]'''
'''| [[Niclosamide labels and packages|Labels and Packages]]'''
==Mechanism of Action==
According to an article in Nature,<ref name="pmid">{{cite journal |author=Weinbach EC, Garbus J |title=Mechanism of action of reagents that uncouple oxidative phosphorylation |journal=Nature |volume=221 |issue=5185 |pages=1016–8 |year=1969 |pmid= |doi=}}</ref> niclosamide uncouples oxidative phosphorylation in the tapeworm.
According to an article in Nature,<ref name="pmid">{{cite journal |author=Weinbach EC, Garbus J |title=Mechanism of action of reagents that uncouple oxidative phosphorylation |journal=Nature |volume=221 |issue=5185 |pages=1016–8 |year=1969 |pmid= |doi=}}</ref> niclosamide uncouples oxidative phosphorylation in the tapeworm.


== References ==
==References==
<references/>
{{Reflist|2}}
* {{cite book |author=Taber, Clarence Wilbur; Venes, Donald; Thomas, Clayton L. |title=Taber's cyclopedic medical dictionary |publisher=F.A.Davis Co |location=Philadelphia |year=2001 |pages= |isbn= |oclc= |doi=}}
*Additional Medication Information:[http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/.html Medline]
*http://www.drugs.com/cons/Niclosamide.html
 


{{Pharma-stub}}
[[Category:Antibiotics]]
{{Anthelmintics}}
[[Category:Wikinfect]]
[[nl:niclosamide]]
[[Category:Anthelmintics]]
{{WikiDoc Sources}}

Revision as of 20:57, 6 January 2014

Niclosamide
YOMESAN® Package Insert
Clinical Pharmacology
Indications
Contraindications
Side Effects
Overdosage
Dosage

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Niclosamide (trade name Niclocide) is a teniacide ("tenia-" referring to tapeworm) in the anthelmintic family especially effective against cestodes that infect humans. It is also used as a piscicide.

It is stressed that while anthelmintics are a drug familiy used to treat worm infections, Niclosamide is used specifically to treat tapeworms and is not effective against worms such as pinworms or roundworms.

It is a chewable tablet taken orally, dosage depending on type of worm and patient's age and/or weight.

Niclosamide molecules are lethal to tapeworms upon contact.

Category

Anthelmintic

US Brand Names

NICLOCIDE, YOMESAN (DISCONTINUED)

FDA Package Insert

Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Overdosage | Clinical Studies | Dosage and Administration | How Supplied | Labels and Packages

Mechanism of Action

According to an article in Nature,[1] niclosamide uncouples oxidative phosphorylation in the tapeworm.

References

  1. ↑ Weinbach EC, Garbus J (1969). "Mechanism of action of reagents that uncouple oxidative phosphorylation". Nature. 221 (5185): 1016–8.
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