Endometrial cancer pathophysiology: Difference between revisions
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{{Endometrial cancer}} | {{Endometrial cancer}} | ||
{{CMG}} | {{CMG}} | ||
==Overview== | ==Overview== | ||
==Patholophysiology== | |||
== | [[Image:Endometrial adenocarcinoma (1).jpg|thumb|right|Endometrial adenocarcinoma]] | ||
[[Image:Endometrial adenocarcinoma (1).jpg|thumb|Endometrial adenocarcinoma]] | |||
====Microscopic pathology==== | ====Microscopic pathology==== | ||
The histopathology of endometrial cancers is highly diverse. The most common finding is a ''well-differentiated endometrioid adenocarcinoma'', which is composed of numerous, small, crowded glands with varying degrees of nuclear atypia, mitotic activity, and stratification. This often appears on a background of endometrial hyperplasia. Frank adenocarcinoma may be distinguished from atypical hyperplasia by the finding of clear stromal invasion, or "back-to-back" glands which represent nondestructive replacement of the endometrial stroma by the cancer. With progression of the disease, the myometrium is infiltrated.<ref name="Weidner's">{{cite book |author=Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor) |title=Modern Surgical Pathology (2 Volume Set) |publisher=W B Saunders |location=London |year= |pages= |isbn=0-7216-7253-1 |oclc= |doi=}}</ref> | The histopathology of endometrial cancers is highly diverse. The most common finding is a ''well-differentiated endometrioid adenocarcinoma'', which is composed of numerous, small, crowded glands with varying degrees of nuclear atypia, mitotic activity, and stratification. This often appears on a background of endometrial hyperplasia. Frank adenocarcinoma may be distinguished from atypical hyperplasia by the finding of clear stromal invasion, or "back-to-back" glands which represent nondestructive replacement of the endometrial stroma by the cancer. With progression of the disease, the myometrium is infiltrated.<ref name="Weidner's">{{cite book |author=Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor) |title=Modern Surgical Pathology (2 Volume Set) |publisher=W B Saunders |location=London |year= |pages= |isbn=0-7216-7253-1 |oclc= |doi=}}</ref> | ||
Revision as of 13:09, 12 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Patholophysiology
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Microscopic pathology
The histopathology of endometrial cancers is highly diverse. The most common finding is a well-differentiated endometrioid adenocarcinoma, which is composed of numerous, small, crowded glands with varying degrees of nuclear atypia, mitotic activity, and stratification. This often appears on a background of endometrial hyperplasia. Frank adenocarcinoma may be distinguished from atypical hyperplasia by the finding of clear stromal invasion, or "back-to-back" glands which represent nondestructive replacement of the endometrial stroma by the cancer. With progression of the disease, the myometrium is infiltrated.[1]
References
- ↑ Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor). Modern Surgical Pathology (2 Volume Set). London: W B Saunders. ISBN 0-7216-7253-1.