Systemic lupus erythematosus differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]

Differential Diagnosis of Disorders that SLE Should be Distinguished from

• Acute disseminated encephalomyelitis
• Acute inflammatory demyelinating polyradiculoneuropathy
• Acute memory disorders
• Blood dyscrasias and stroke
• Brainstem gliomas
• Cardioembolic stroke
• Chorea in adults
• Chronic inflammatory demyelinating polyradiculoneuropathy
• Confusional states
• Dermatomyositis
• Diffuse sclerosis
• Endocrine myopathies
• HIV-1 associated CNS complications
• Intracranial hemorrhage
• Lambert-Eaton myasthenic syndrome
• Lyme disease
• Metabolic myopathies
• Myasthenia gravis
• Neurological sequelae of infectious endocarditis
• Polyarteritis nodosa
• Polymyositis
• Spinal cord infarction
• Sudden visual loss
• Temporal / Giant cell arteritis
• Vasculitic neuropathy

Common dual diagnoses

SLE is sometimes diagnosed in conjunction with other conditions, including Rheumatoid Arthritis, Scurvy and Fibromyalgia.