Rheumatoid arthritis causes: Difference between revisions
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{{Rheumatoid arthritis}} | {{Rheumatoid arthritis}} | ||
{{CMG}} {{AE}} {{AN}} | {{CMG}}; {{AE}} {{AN}} | ||
==Overview== | ==Overview== | ||
==Causes== | ==Causes== | ||
*The cause of RA is still unknown to this day. | *The cause of RA is still unknown to this day. | ||
*In considering possible causes, it is important to distinguish between the cause(s) that trigger the inflammatory process, and those that may permit it to persist and even progress from milder to more severe forms of inflammation. | *In considering possible causes, it is important to distinguish between the cause(s) that trigger the [[inflammatory]] process, and those that may permit it to persist and even progress from milder to more severe forms of inflammation. | ||
*Thus, it has long been suspected that certain infections could be triggers for this disease. As in other autoimmune diseases, the "mistaken identity" theory suggests that an offending organism causes an immune response that leaves behind antibodies that are specific to that organism. | *Thus, it has long been suspected that certain infections could be triggers for this disease. As in other autoimmune diseases, the "mistaken identity" theory suggests that an offending organism causes an immune response that leaves behind antibodies that are specific to that organism. | ||
*The antibodies are not specific enough, though. They begin an immune attack against, in this case, the [[synovium]], because some molecule in the synovium "looks like" a molecule on the offending organism that created the initial immune reaction - this phenomenon is called [[molecular mimicry]]. | *The antibodies are not specific enough, though. They begin an immune attack against, in this case, the [[synovium]], because some molecule in the synovium "looks like" a molecule on the offending organism that created the initial immune reaction - this phenomenon is called [[molecular mimicry]]. | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Aging-associated diseases]] | |||
[[Category:Arthritis]] | |||
[[Category:Autoimmune diseases]] | |||
[[Category:Diseases involving the fasciae]] | |||
[[Category:Rheumatology]] | |||
Revision as of 16:56, 5 November 2012
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Rheumatoid arthritis Microchapters | |
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Rheumatoid arthritis causes On the Web | |
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American Roentgen Ray Society Images of Rheumatoid arthritis causes | |
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Risk calculators and risk factors for Rheumatoid arthritis causes | |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2]
Overview
Causes
- The cause of RA is still unknown to this day.
- In considering possible causes, it is important to distinguish between the cause(s) that trigger the inflammatory process, and those that may permit it to persist and even progress from milder to more severe forms of inflammation.
- Thus, it has long been suspected that certain infections could be triggers for this disease. As in other autoimmune diseases, the "mistaken identity" theory suggests that an offending organism causes an immune response that leaves behind antibodies that are specific to that organism.
- The antibodies are not specific enough, though. They begin an immune attack against, in this case, the synovium, because some molecule in the synovium "looks like" a molecule on the offending organism that created the initial immune reaction - this phenomenon is called molecular mimicry.