Buergers disease

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Buerger's disease
Buerger's Disease of the Hand
ICD-10	I73.1
ICD-9	443.1
OMIM	211480
DiseasesDB	1762
MeSH	C14.907.137.870

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Thromboangiitis obliterans

Not to be confused with Berger's disease (IgA nephropathy)

Features

There is a recurrent acute and chronic inflammation and thrombosis of arteries and veins of the hands and feet. The main symptom is pain in the affected areas. Ulcerations and gangrene in the extremities are common complications, often resulting in the need for amputation of the involved extremity.

Diagnosis

A concrete diagnosis of thromboangiitis obliterans is often difficult as it relies heavily on exclusion of the conditions. The commonly followed diagnostic criteria are below although the criteria tend to differ slightly from author to author. Olin (2000) proposes the following criteria:

1. Age younger than 45 years
2. Current (or recent) history of tobacco use
3. Presence of distal extremity ischemia (indicated by claudication, pain at rest, ischemic ulcers or gangrene) documented by noninvasive vascular testing such as ultrasound
4. Exclusion of autoimmune diseases, hypercoagulable states, and diabetes mellitus by laboratory tests.
5. Exclusion of a proximal source of emboli by echocardiography and arteriography
6. Consistent arteriographic findings in the clinically involved and noninvolved limbs.

Diagnostic Findings

• 

  Thromboangiitis Obliterans (Buerger's disease): Arterial vascular disease associated with smoking. Note the blackened tips of middle and pinky fingers.
  (Image courtesy of Charlie Goldberg, M.D.)

Pathophysiology

There are characteristic pathologic findings of acute inflammation and thrombosis (clotting) of arteries and veins of the hands and feet (the lower limbs being more common). The mechanisms underlying Buerger's disease are still largely unknown. It is suspected that immunological reactions play a role.

Treatment

Symptoms are treated as there is no treatment for the disease. Cessation of tobacco use may slow any further progression of the disease. Vascular surgery can sometimes be helpful in treating limbs with poor perfusion secondary to this disease. Use of vascular growth factor and stem cell injections have been showing promise in clinical studies.

Prognosis

Amputation is common and more severe in patients who continue to use tobacco. It often leads to vascular insufficiency. Buerger's is rarely immediately fatal, but rather a life shortening disease.

External Links

Buerger's Disease]

de:Endangiitis obliterans he:מחלת בירגר nl:Ziekte van Buerger sv:Morbus Buerger

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