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'''Breast cancer metastasis-suppressor 1''' is a [[protein]] that in humans is encoded by the ''BRMS1'' [[gene]].<ref name="pmid10850410">{{cite journal | vauthors = Seraj MJ, Samant RS, Verderame MF, Welch DR | title = Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13 | journal = Cancer Res | volume = 60 | issue = 11 | pages = 2764–9 |date=Jun 2000 | pmid = 10850410 | pmc = | doi = }}</ref><ref name="entrez"/>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Breast cancer metastasis suppressor 1
| HGNCid = 17262
| Symbol = BRMS1
| AltSymbols =; DKFZp564A063
| OMIM = 606259
| ECnumber = 
| Homologene = 32260
| MGIid = 2388804
| GeneAtlas_image1 = PBB_GE_BRMS1_215631_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 25855
    | Hs_Ensembl = ENSG00000174744
    | Hs_RefseqProtein = NP_001020128
    | Hs_RefseqmRNA = NM_001024957
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 65861380
    | Hs_GenLoc_end = 65869158
    | Hs_Uniprot = Q9HCU9
    | Mm_EntrezGene = 107392
    | Mm_Ensembl = ENSMUSG00000024888
    | Mm_RefseqmRNA = NM_134155
    | Mm_RefseqProtein = NP_598916
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 5045900
    | Mm_GenLoc_end = 5049037
    | Mm_Uniprot = Q547N0
  }}
}}
'''Breast cancer [[metastasis suppressor]] 1''', also known as '''BRMS1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BRMS1 breast cancer metastasis suppressor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25855| accessdate = }}</ref>


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| section_title =  
| section_title =  
| summary_text = This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines.<ref>[http://www.sciencedaily.com/releases/2000/06/000612084928.htm Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene<!-- Bot generated title -->]</ref> The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: BRMS1 breast cancer metastasis suppressor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25855| accessdate = }}</ref>
| summary_text = This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines.<ref>[http://www.sciencedaily.com/releases/2000/06/000612084928.htm Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene<!-- Bot generated title -->]</ref> The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: BRMS1 breast cancer metastasis suppressor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25855| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|BRMS1}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Meehan WJ, Welch DR |title=Breast cancer metastasis suppressor 1: update. |journal=Clin. Exp. Metastasis |volume=20 |issue= 1 |pages= 45-50 |year= 2003 |pmid= 12650606 |doi=  }}
*{{cite journal  | vauthors=Meehan WJ, Welch DR |title=Breast cancer metastasis suppressor 1: update. |journal=Clin. Exp. Metastasis |volume=20 |issue= 1 |pages= 45–50 |year= 2003 |pmid= 12650606 |doi=10.1023/A:1022542519586 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Seraj MJ, Samant RS, Verderame MF, Welch DR |title=Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13. |journal=Cancer Res. |volume=60 |issue= 11 |pages= 2764-9 |year= 2000 |pmid= 10850410 |doi= }}
*{{cite journal  | vauthors=Samant RS, Debies MT, Shevde LA |title=Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1). |journal=Int. J. Cancer |volume=97 |issue= 1 |pages= 15–20 |year= 2002 |pmid= 11774238 |doi=10.1002/ijc.1569 |display-authors=etal}}
*{{cite journal  | author=Samant RS, Debies MT, Shevde LA, ''et al.'' |title=Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1). |journal=Int. J. Cancer |volume=97 |issue= 1 |pages= 15-20 |year= 2002 |pmid= 11774238 |doi=  }}
*{{cite journal  | vauthors=Shevde LA, Samant RS, Goldberg SF |title=Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1. |journal=Exp. Cell Res. |volume=273 |issue= 2 |pages= 229–39 |year= 2002 |pmid= 11822878 |doi= 10.1006/excr.2001.5452 |display-authors=etal}}
*{{cite journal  | author=Shevde LA, Samant RS, Goldberg SF, ''et al.'' |title=Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1. |journal=Exp. Cell Res. |volume=273 |issue= 2 |pages= 229-39 |year= 2002 |pmid= 11822878 |doi= 10.1006/excr.2001.5452 }}
*{{cite journal  | vauthors=Janneau JL, Maldonado-Estrada J, Tachdjian G |title=Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 11 |pages= 5336–9 |year= 2002 |pmid= 12414911 |doi=10.1210/jc.2002-021093 |display-authors=etal}}
*{{cite journal  | author=Janneau JL, Maldonado-Estrada J, Tachdjian G, ''et al.'' |title=Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 11 |pages= 5336-9 |year= 2002 |pmid= 12414911 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Meehan WJ, Samant RS, Hopper JE |title=Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription |journal=J. Biol. Chem. |volume=279 |issue= 2 |pages= 1562–9 |year= 2004 |pmid= 14581478 |doi= 10.1074/jbc.M307969200 |display-authors=etal}}
*{{cite journal  | author=Meehan WJ, Samant RS, Hopper JE, ''et al.'' |title=Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription. |journal=J. Biol. Chem. |volume=279 |issue= 2 |pages= 1562-9 |year= 2004 |pmid= 14581478 |doi= 10.1074/jbc.M307969200 }}
*{{cite journal  | vauthors=Cicek M, Samant RS, Kinter M |title=Identification of metastasis-associated proteins through protein analysis of metastatic MDA-MB-435 and metastasis-suppressed BRMS1 transfected-MDA-MB-435 cells |journal=Clin. Exp. Metastasis |volume=21 |issue= 2 |pages= 149–57 |year= 2004 |pmid= 15168732 |doi=10.1023/B:CLIN.0000024729.19084.f0 |display-authors=etal}}
*{{cite journal  | author=Cicek M, Samant RS, Kinter M, ''et al.'' |title=Identification of metastasis-associated proteins through protein analysis of metastatic MDA-MB-435 and metastasis-suppressed BRMS1 transfected-MDA-MB-435 cells. |journal=Clin. Exp. Metastasis |volume=21 |issue= 2 |pages= 149-57 |year= 2004 |pmid= 15168732 |doi=  }}
*{{cite journal  | vauthors=Nikolaev AY, Papanikolaou NA, Li M |title=Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex |journal=Biochem. Biophys. Res. Commun. |volume=323 |issue= 4 |pages= 1216–22 |year= 2004 |pmid= 15451426 |doi= 10.1016/j.bbrc.2004.08.227 |display-authors=etal}}
*{{cite journal  | author=Nikolaev AY, Papanikolaou NA, Li M, ''et al.'' |title=Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex. |journal=Biochem. Biophys. Res. Commun. |volume=323 |issue= 4 |pages= 1216-22 |year= 2004 |pmid= 15451426 |doi= 10.1016/j.bbrc.2004.08.227 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Stark AM, Tongers K, Maass N |title=Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases |journal=J. Cancer Res. Clin. Oncol. |volume=131 |issue= 3 |pages= 191–8 |year= 2005 |pmid= 15592684 |doi= 10.1007/s00432-004-0629-9 |display-authors=etal}}
*{{cite journal  | author=Stark AM, Tongers K, Maass N, ''et al.'' |title=Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases. |journal=J. Cancer Res. Clin. Oncol. |volume=131 |issue= 3 |pages= 191-8 |year= 2005 |pmid= 15592684 |doi= 10.1007/s00432-004-0629-9 }}
*{{cite journal  | vauthors=DeWald DB, Torabinejad J, Samant RS |title=Metastasis suppression by breast cancer metastasis suppressor 1 involves reduction of phosphoinositide signaling in MDA-MB-435 breast carcinoma cells |journal=Cancer Res. |volume=65 |issue= 3 |pages= 713–7 |year= 2005 |pmid= 15705865 |doi=  |display-authors=etal}}
*{{cite journal  | author=DeWald DB, Torabinejad J, Samant RS, ''et al.'' |title=Metastasis suppression by breast cancer metastasis suppressor 1 involves reduction of phosphoinositide signaling in MDA-MB-435 breast carcinoma cells. |journal=Cancer Res. |volume=65 |issue= 3 |pages= 713-7 |year= 2005 |pmid= 15705865 |doi=  }}
*{{cite journal  | vauthors=Cicek M, Fukuyama R, Welch DR |title=Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activity |journal=Cancer Res. |volume=65 |issue= 9 |pages= 3586–95 |year= 2005 |pmid= 15867352 |doi= 10.1158/0008-5472.CAN-04-3139 |display-authors=etal}}
*{{cite journal  | author=Cicek M, Fukuyama R, Welch DR, ''et al.'' |title=Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activity. |journal=Cancer Res. |volume=65 |issue= 9 |pages= 3586-95 |year= 2005 |pmid= 15867352 |doi= 10.1158/0008-5472.CAN-04-3139 }}
*{{cite journal  | vauthors=Hurst DR, Mehta A, Moore BP |title=Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone |journal=Biochem. Biophys. Res. Commun. |volume=348 |issue= 4 |pages= 1429–35 |year= 2006 |pmid= 16919237 |doi= 10.1016/j.bbrc.2006.08.005 | pmc=1557677 |display-authors=etal}}
*{{cite journal  | author=Hurst DR, Mehta A, Moore BP, ''et al.'' |title=Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone. |journal=Biochem. Biophys. Res. Commun. |volume=348 |issue= 4 |pages= 1429-35 |year= 2006 |pmid= 16919237 |doi= 10.1016/j.bbrc.2006.08.005 }}
*{{cite journal  | vauthors=Samant RS, Clark DW, Fillmore RA |title=Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-κB activation |journal=Mol. Cancer |volume=6 |issue=  |pages= 6 |year= 2007 |pmid= 17227585 |doi= 10.1186/1476-4598-6-6 | pmc=1796551 |display-authors=etal}}
*{{cite journal  | author=Samant RS, Clark DW, Fillmore RA, ''et al.'' |title=Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-kappaB activation. |journal=Mol. Cancer |volume=6 |issue=  |pages= 6 |year= 2007 |pmid= 17227585 |doi= 10.1186/1476-4598-6-6 }}
*{{cite journal  | vauthors=Rivera J, Megias D, Bravo J |title=Proteomics-based strategy to delineate the molecular mechanisms of the metastasis suppressor gene BRMS1 |journal=J. Proteome Res. |volume=6 |issue= 10 |pages= 4006–18 |year= 2007 |pmid= 17854218 |doi= 10.1021/pr0703167 }}
*{{cite journal  | author=Rivera J, Megias D, Bravo J |title=Proteomics-based strategy to delineate the molecular mechanisms of the metastasis suppressor gene BRMS1. |journal=J. Proteome Res. |volume=6 |issue= 10 |pages= 4006-18 |year= 2007 |pmid= 17854218 |doi= 10.1021/pr0703167 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 02:40, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Breast cancer metastasis-suppressor 1 is a protein that in humans is encoded by the BRMS1 gene.[1][2]

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines.[3] The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.[2]

References

  1. ↑ Seraj MJ, Samant RS, Verderame MF, Welch DR (Jun 2000). "Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13". Cancer Res. 60 (11): 2764–9. PMID 10850410.
  2. ↑ 2.0 2.1 "Entrez Gene: BRMS1 breast cancer metastasis suppressor 1".
  3. ↑ Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene

External links

Further reading



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