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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Nuclear nucleic acid-binding protein C1D''' is a [[protein]] that in humans is encoded by the ''C1D'' [[gene]].<ref name="pmid9469821">{{cite journal | vauthors = Nehls P, Keck T, Greferath R, Spiess E, Glaser T, Rothbarth K, Stammer H, Werner D | title = cDNA cloning, recombinant expression and characterization of polypetides with exceptional DNA affinity | journal = Nucleic Acids Res. | volume = 26 | issue = 5 | pages = 1160–6  | date = Apr 1998 | pmid = 9469821 | pmc = 147382 | doi = 10.1093/nar/26.5.1160 }}</ref><ref name="pmid17599775">{{cite journal | vauthors = Schilders G, Egberts WV, Raijmakers R, Pruijn GJ | title = C1D is a major autoantibody target in patients with the polymyositis-scleroderma overlap syndrome | journal = Arthritis Rheum. | volume = 56 | issue = 7 | pages = 2449–54  | date = Jul 2007 | pmid = 17599775 | pmc =  | doi = 10.1002/art.22710 }}</ref><ref name="pmid17412707">{{cite journal | vauthors = Schilders G, van Dijk E, Pruijn GJ | title = C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing | journal = Nucleic Acids Res. | volume = 35 | issue = 8 | pages = 2564–72  | date = May 2007 | pmid = 17412707 | pmc = 1885644 | doi = 10.1093/nar/gkm082 }}</ref><ref name="pmid11801738">{{cite journal | vauthors = Erdemir T, Bilican B, Oncel D, Goding CR, Yavuzer U | title = DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX) | journal = J. Cell Sci. | volume = 115 | issue = Pt 1 | pages = 207–16  | date = Jan 2002 | pmid = 11801738 | pmc =  | doi =  }}</ref><ref name="pmid9405624">{{cite journal | vauthors = Zamir I, Dawson J, Lavinsky RM, Glass CK, Rosenfeld MG, Lazar MA | title = Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 26 | pages = 14400–5 | year = 1997 | date = Feb 1998 | pmid = 9405624 | pmc = 24996 | doi = 10.1073/pnas.94.26.14400 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: C1D nuclear DNA-binding protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10438| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Nuclear DNA-binding protein
| HGNCid = 
| Symbol = C1D
| AltSymbols =; MGC12261; MGC14659; SUNCOR
| OMIM = 606997
| ECnumber = 
| Homologene = 89227
| MGIid = 
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10438
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_006324
    | Hs_RefseqmRNA = NM_006333
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Nuclear DNA-binding protein''', also known as '''C1D''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: C1D nuclear DNA-binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10438| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Several alternatively spliced transcript variants of this gene have been described, but the full length nature of some of these variants has not been determined.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Several alternatively spliced transcript variants of this gene have been described, but the full length nature of some of these variants has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: C1D nuclear DNA-binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10438| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
C1D has been shown to [[Protein-protein interaction|interact]] with [[TSNAX]]<ref name=autogenerated1>{{cite journal | vauthors = Erdemir T, Bilican B, Oncel D, Goding CR, Yavuzer U | title = DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX) | journal = J. Cell Sci. | volume = 115 | issue = Pt 1 | pages = 207–16  | date = Jan 2002 | pmid = 11801738 }}</ref> and [[DNA-PKcs]].<ref name=pmid9679063>{{cite journal | vauthors = Yavuzer U, Smith GC, Bliss T, Werner D, Jackson SP | title = DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D | journal = Genes Dev. | volume = 12 | issue = 14 | pages = 2188–99  | date = Jul 1998 | pmid = 9679063 | pmc = 317006 | doi = 10.1101/gad.12.14.2188 }}</ref>
 
== References ==
{{reflist}}
 
==External links==
* {{UCSC gene info|C1D}}
* {{UCSC gene info|LRP1}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
| citations =
* {{cite journal | vauthors = Rothbarth K, Stammer H, Werner D | title = Proteasome-mediated degradation antagonizes critical levels of the apoptosis-inducing C1D protein | journal = Cancer Cell Int. | volume = 2 | issue = 1 | pages = 12 | year = 2002 | pmid = 12379155 | pmc = 140130 | doi = 10.1186/1475-2867-2-12 }}
*{{cite journal | author=Schilders G, Egberts WV, Raijmakers R, Pruijn GJ |title=C1D is a major autoantibody target in patients with the polymyositis-scleroderma overlap syndrome. |journal=Arthritis Rheum. |volume=56 |issue= 7 |pages= 2449-54 |year= 2007 |pmid= 17599775 |doi= 10.1002/art.22710 }}
* {{cite journal | vauthors = Rothbarth K, Hunziker A, Stammer H, Werner D | title = Promoter of the gene encoding the 16 kDa DNA-binding and apoptosis-inducing C1D protein | journal = Biochim. Biophys. Acta | volume = 1518 | issue = 3 | pages = 271–5 | year = 2001 | pmid = 11311939 | doi = 10.1016/S0167-4781(01)00198-1 }}
*{{cite journal  | author=Schilders G, van Dijk E, Pruijn GJ |title=C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing. |journal=Nucleic Acids Res. |volume=35 |issue= 8 |pages= 2564-72 |year= 2007 |pmid= 17412707 |doi= 10.1093/nar/gkm082 }}
* {{cite journal | vauthors = Rothbarth K, Spiess E, Juodka B, Yavuzer U, Nehls P, Stammer H, Werner D | title = Induction of apoptosis by overexpression of the DNA-binding and DNA-PK-activating protein C1D | journal = J. Cell Sci. | volume = 112 ( Pt 13) | issue = 13 | pages = 2223–32 | year = 1999 | pmid = 10362552 | doi =  }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
* {{cite journal | vauthors = Haataja L, Groffen J, Heisterkamp N | title = Identification of a novel Rac3-interacting protein C1D | journal = Int. J. Mol. Med. | volume = 1 | issue = 4 | pages = 665–70 | year = 1998 | pmid = 9852280 | doi = 10.3892/ijmm.1.4.665 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Yavuzer U, Smith GC, Bliss T, Werner D, Jackson SP | title = DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D | journal = Genes Dev. | volume = 12 | issue = 14 | pages = 2188–99 | year = 1998 | pmid = 9679063 | pmc = 317006 | doi = 10.1101/gad.12.14.2188 }}
*{{cite journal  | author=Rothbarth K, Stammer H, Werner D |title=Proteasome-mediated degradation antagonizes critical levels of the apoptosis-inducing C1D protein. |journal= |volume=2 |issue= 1 |pages= 12 |year= |pmid= 12379155 |doi= }}
*{{cite journal  | author=Erdemir T, Bilican B, Oncel D, ''et al.'' |title=DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX). |journal=J. Cell. Sci. |volume=115 |issue= Pt 1 |pages= 207-16 |year= 2002 |pmid= 11801738 |doi=  }}
*{{cite journal | author=Rothbarth K, Hunziker A, Stammer H, Werner D |title=Promoter of the gene encoding the 16 kDa DNA-binding and apoptosis-inducing C1D protein. |journal=Biochim. Biophys. Acta |volume=1518 |issue= 3 |pages= 271-5 |year= 2001 |pmid= 11311939 |doi= }}
*{{cite journal | author=Rothbarth K, Spiess E, Juodka B, ''et al.'' |title=Induction of apoptosis by overexpression of the DNA-binding and DNA-PK-activating protein C1D. |journal=J. Cell. Sci. |volume=112 ( Pt 13) |issue= |pages= 2223-32 |year= 1999 |pmid= 10362552 |doi=  }}
*{{cite journal | author=Haataja L, Groffen J, Heisterkamp N |title=Identification of a novel Rac3-interacting protein C1D. |journal=Int. J. Mol. Med. |volume=1 |issue= 4 |pages= 665-70 |year= 1999 |pmid= 9852280 |doi= }}
*{{cite journal | author=Yavuzer U, Smith GC, Bliss T, ''et al.'' |title=DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D. |journal=Genes Dev. |volume=12 |issue= 14 |pages= 2188-99 |year= 1998 |pmid= 9679063 |doi=  }}
*{{cite journal  | author=Nehls P, Keck T, Greferath R, ''et al.'' |title=cDNA cloning, recombinant expression and characterization of polypetides with exceptional DNA affinity. |journal=Nucleic Acids Res. |volume=26 |issue= 5 |pages= 1160-6 |year= 1998 |pmid= 9469821 |doi= }}
*{{cite journal  | author=Zamir I, Dawson J, Lavinsky RM, ''et al.'' |title=Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 26 |pages= 14400-5 |year= 1998 |pmid= 9405624 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{protein-stub}}
{{WikiDoc Sources}}

Revision as of 19:27, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Nuclear nucleic acid-binding protein C1D is a protein that in humans is encoded by the C1D gene.[1][2][3][4][5][6]

Function

The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Several alternatively spliced transcript variants of this gene have been described, but the full length nature of some of these variants has not been determined.[6]

Interactions

C1D has been shown to interact with TSNAX[7] and DNA-PKcs.[8]

References

  1. ↑ Nehls P, Keck T, Greferath R, Spiess E, Glaser T, Rothbarth K, Stammer H, Werner D (Apr 1998). "cDNA cloning, recombinant expression and characterization of polypetides with exceptional DNA affinity". Nucleic Acids Res. 26 (5): 1160–6. doi:10.1093/nar/26.5.1160. PMC 147382. PMID 9469821.
  2. ↑ Schilders G, Egberts WV, Raijmakers R, Pruijn GJ (Jul 2007). "C1D is a major autoantibody target in patients with the polymyositis-scleroderma overlap syndrome". Arthritis Rheum. 56 (7): 2449–54. doi:10.1002/art.22710. PMID 17599775.
  3. ↑ Schilders G, van Dijk E, Pruijn GJ (May 2007). "C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing". Nucleic Acids Res. 35 (8): 2564–72. doi:10.1093/nar/gkm082. PMC 1885644. PMID 17412707.
  4. ↑ Erdemir T, Bilican B, Oncel D, Goding CR, Yavuzer U (Jan 2002). "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)". J. Cell Sci. 115 (Pt 1): 207–16. PMID 11801738.
  5. ↑ Zamir I, Dawson J, Lavinsky RM, Glass CK, Rosenfeld MG, Lazar MA (Feb 1998). "Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14400–5. doi:10.1073/pnas.94.26.14400. PMC 24996. PMID 9405624. Check date values in: |year= / |date= mismatch (help)
  6. ↑ 6.0 6.1 "Entrez Gene: C1D nuclear DNA-binding protein".
  7. ↑ Erdemir T, Bilican B, Oncel D, Goding CR, Yavuzer U (Jan 2002). "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)". J. Cell Sci. 115 (Pt 1): 207–16. PMID 11801738.
  8. ↑ Yavuzer U, Smith GC, Bliss T, Werner D, Jackson SP (Jul 1998). "DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D". Genes Dev. 12 (14): 2188–99. doi:10.1101/gad.12.14.2188. PMC 317006. PMID 9679063.

External links

Further reading


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