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{{Infobox_gene}}
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'''Calpain-10''' is a [[protein]] that in humans is encoded by the ''CAPN10'' [[gene]].<ref name="pmid11017071">{{cite journal | vauthors = Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, Hinokio Y, Lindner TH, Mashima H, Schwarz PE, del Bosque-Plata L, Horikawa Y, Oda Y, Yoshiuchi I, Colilla S, Polonsky KS, Wei S, Concannon P, Iwasaki N, Schulze J, Baier LJ, Bogardus C, Groop L, Boerwinkle E, Hanis CL, Bell GI | title = Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus | journal = Nat Genet | volume = 26 | issue = 2 | pages = 163–75 |date=Nov 2000 | pmid = 11017071 | pmc =  | doi = 10.1038/79876 }}</ref><ref name="pmid11018080">{{cite journal | vauthors = Baier LJ, Permana PA, Yang X, Pratley RE, Hanson RL, Shen GQ, Mott D, Knowler WC, Cox NJ, Horikawa Y, Oda N, Bell GI, Bogardus C | title = A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance | journal = J Clin Invest | volume = 106 | issue = 7 | pages = R69–73 |date=Oct 2000 | pmid = 11018080 | pmc = 387246 | doi = 10.1172/JCI10665 }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Calpain 10
| HGNCid = 1477
| Symbol = CAPN10
| AltSymbols =;
| OMIM = 605286
| ECnumber =
| Homologene = 36323
| MGIid = 1344392
  | GeneAtlas_image1 = PBB_GE_CAPN10_219333_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CAPN10_221040_at_tn.png
| Function = {{GNF_GO|id=GO:0004198 |text = calpain activity}}  
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11132
    | Hs_Ensembl = ENSG00000142330
    | Hs_RefseqProtein = NP_067074
    | Hs_RefseqmRNA = NM_021251
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 241174825
    | Hs_GenLoc_end = 241205088
    | Hs_Uniprot = Q9HC96
    | Mm_EntrezGene = 23830
    | Mm_Ensembl = ENSMUSG00000026270
    | Mm_RefseqmRNA = NM_011796
    | Mm_RefseqProtein = NP_035926
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 94764782
    | Mm_GenLoc_end = 94778346
    | Mm_Uniprot = Q9ESK3
  }}
}}
'''Calpain 10''', also known as '''CAPN10''', is a human [[gene]].


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{{PBB_Summary
{{PBB Summary
| section_title =  
| section_title =  
| summary_text = Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: CAPN10 calpain 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11132| accessdate = }}</ref>
| summary_text = [[Calpain]]s are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The typical calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain.  The heterodimer interface is predominantly found between domain IV and the small subunit, which is also a calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain.  It therefore cannot heterodimerize with the small subunit. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: CAPN10 calpain 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11132| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Sorimachi H, Ishiura S, Suzuki K |title=Structure and physiological function of calpains. |journal=Biochem. J. |volume=328 ( Pt 3) |issue=  |pages= 721-32 |year= 1998 |pmid= 9396712 |doi=  }}
*{{cite journal  | vauthors=Sorimachi H, Ishiura S, Suzuki K |title=Structure and physiological function of calpains. |journal=Biochem. J. |volume=328 |issue=  3|pages= 721–32 |year= 1998 |pmid= 9396712 |doi= 10.1042/bj3280721| pmc=1218978 }}
*{{cite journal  | author=Cox NJ, Hayes MG, Roe CA, ''et al.'' |title=Linkage of calpain 10 to type 2 diabetes: the biological rationale. |journal=Diabetes |volume=53 Suppl 1 |issue=  |pages= S19-25 |year= 2004 |pmid= 14749261 |doi=  }}
*{{cite journal  | author=Cox NJ |title=Linkage of calpain 10 to type 2 diabetes: the biological rationale |journal=Diabetes |volume=53 Suppl 1 |issue=  |pages= S19–25 |year= 2004 |pmid= 14749261 |doi=  10.2337/diabetes.53.2007.s19|name-list-format=vanc| author2=Hayes MG  | author3=Roe CA  | display-authors=3  | last4=Tsuchiya  | first4=T  | last5=Bell  | first5=GI  }}
*{{cite journal  | author=Turner MD, Cassell PG, Hitman GA |title=Calpain-10: from genome search to function. |journal=Diabetes Metab. Res. Rev. |volume=21 |issue= 6 |pages= 505-14 |year= 2006 |pmid= 16028216 |doi= 10.1002/dmrr.578 }}
*{{cite journal  | vauthors=Turner MD, Cassell PG, Hitman GA |title=Calpain-10: from genome search to function |journal=Diabetes Metab. Res. Rev. |volume=21 |issue= 6 |pages= 505–14 |year= 2006 |pmid= 16028216 |doi= 10.1002/dmrr.578 }}
*{{cite journal  | author=Horikawa Y |title=Calpain-10 (NIDDM1) as a Susceptibility Gene for Common Type 2 Diabetes. |journal=Endocr. J. |volume=53 |issue= 5 |pages= 567-76 |year= 2007 |pmid= 16873988 |doi= }}
*{{cite journal  | author=Horikawa Y |title=Calpain-10 (NIDDM1) as a Susceptibility Gene for Common Type 2 Diabetes |journal=Endocr. J. |volume=53 |issue= 5 |pages= 567–76 |year= 2007 |pmid= 16873988 |doi=10.1507/endocrj.KR-70  }}
*{{cite journal  | author=Horikawa Y, Oda N, Cox NJ, ''et al.'' |title=Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. |journal=Nat. Genet. |volume=26 |issue= 2 |pages= 163-75 |year= 2000 |pmid= 11017071 |doi= 10.1038/79876 }}
*{{cite journal  | author=Nagase T |title=Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=8 |issue= 2 |pages= 85–95 |year= 2001 |pmid= 11347906 |doi=10.1093/dnares/8.2.85 |name-list-format=vanc| author2=Nakayama M | author3=Nakajima D | display-authors=3  | last4=Kikuno  | first4=R  | last5=Ohara  | first5=O }}
*{{cite journal  | author=Baier LJ, Permana PA, Yang X, ''et al.'' |title=A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance. |journal=J. Clin. Invest. |volume=106 |issue= 7 |pages= R69-73 |year= 2000 |pmid= 11018080 |doi= }}
*{{cite journal  | author=Ma H |title=Characterization and expression of calpain 10. A novel ubiquitous calpain with nuclear localization |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 28525–31 |year= 2001 |pmid= 11375982 |doi= 10.1074/jbc.M100603200  |name-list-format=vanc| author2=Fukiage C  | author3=Kim YH  | display-authors=3  | last4=Duncan  | first4=MK  | last5=Reed  | first5=NA  | last6=Shih  | first6=M  | last7=Azuma  | first7=M  | last8=Shearer | first8=TR }}
*{{cite journal | author=Nagase T, Nakayama M, Nakajima D, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=8 |issue= 2 |pages= 85-95 |year= 2001 |pmid= 11347906 |doi=  }}
*{{cite journal  | author=Evans JC |title=Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom |journal=Am. J. Hum. Genet. |volume=69 |issue= 3 |pages= 544–52 |year= 2001 |pmid= 11481585 |doi=10.1086/323315 | pmc=1235484 |name-list-format=vanc| author2=Frayling TM  | author3=Cassell PG  | display-authors=3  | last4=Saker  | first4=Philip J.  | last5=Hitman  | first5=Graham A.  | last6=Walker  | first6=Mark | last7=Levy  | first7=Jonathan C.  | last8=o’Rahilly  | first8=Stephen  | last9=Rao  | first9=Pamidighantam V. Subba  }}
*{{cite journal  | author=Ma H, Fukiage C, Kim YH, ''et al.'' |title=Characterization and expression of calpain 10. A novel ubiquitous calpain with nuclear localization. |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 28525-31 |year= 2001 |pmid= 11375982 |doi= 10.1074/jbc.M100603200 }}
*{{cite journal  | author=Tsai HJ |title=Type 2 diabetes and three calpain-10 gene polymorphisms in Samoans: no evidence of association |journal=Am. J. Hum. Genet. |volume=69 |issue= 6 |pages= 1236–44 |year= 2002 |pmid= 11704924 |doi=10.1086/324646 | pmc=1235535 |name-list-format=vanc| author2=Sun G  | author3=Weeks DE  | display-authors=3  | last4=Kaushal  | first4=Ritesh  | last5=Wolujewicz  | first5=Michael  | last6=McGarvey  | first6=Stephen T.  | last7=Tufa  | first7=Joseph  | last8=Viali  | first8=Satupaitea  | last9=Deka  | first9=Ranjan }}
*{{cite journal | author=Evans JC, Frayling TM, Cassell PG, ''et al.'' |title=Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom. |journal=Am. J. Hum. Genet. |volume=69 |issue= 3 |pages= 544-52 |year= 2001 |pmid= 11481585 |doi=  }}
*{{cite journal  | vauthors=Woollard JR, Rothschild MF |title=Assignment of the porcine calpain-10 gene (CAPN10) to chromosome 15q23-26 |journal=Anim. Genet. |volume=32 |issue= 6 |pages= 393–393 |year= 2002 |pmid= 11736815 |doi=10.1046/j.1365-2052.2001.0781d.x  }}
*{{cite journal  | author=Tsai HJ, Sun G, Weeks DE, ''et al.'' |title=Type 2 diabetes and three calpain-10 gene polymorphisms in Samoans: no evidence of association. |journal=Am. J. Hum. Genet. |volume=69 |issue= 6 |pages= 1236-44 |year= 2002 |pmid= 11704924 |doi=  }}
*{{cite journal  | author=Xiang K |title=[The impact of calpain-10 gene combined-SNP variation on type 2 diabetes mellitus and its related metabolic traits] |journal=Zhonghua Yi Xue Yi Chuan Xue Za Zhi |volume=18 |issue= 6 |pages= 426–30 |year= 2002 |pmid= 11774208 |doi=  |name-list-format=vanc| author2=Fang Q | author3=Zheng T  | display-authors=3  | last4=Jia  | first4=W  | last5=Wang  | first5=Y  | last6=Zhang  | first6=R  | last7=Li | first7=J  | last8=Shen  | first8=K  }}
*{{cite journal | author=Woollard JR, Rothschild MF |title=Assignment of the porcine calpain-10 gene (CAPN10) to chromosome 15q23-26. |journal=Anim. Genet. |volume=32 |issue= 6 |pages= 393 |year= 2002 |pmid= 11736815 |doi=  }}
*{{cite journal  | author=Elbein SC |title=Role of calpain-10 gene variants in familial type 2 diabetes in Caucasians |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 2 |pages= 650–4 |year= 2002 |pmid= 11836299 |doi=10.1210/jc.87.2.650 |name-list-format=vanc| author2=Chu W  | author3=Ren Q  | display-authors=3  | last4=Hemphill  | first4=C  | last5=Schay  | first5=J  | last6=Cox  | first6=NJ  | last7=Hanis  | first7=CL  | last8=Hasstedt  | first8=SJ }}
*{{cite journal  | author=Xiang K, Fang Q, Zheng T, ''et al.'' |title=[The impact of calpain-10 gene combined-SNP variation on type 2 diabetes mellitus and its related metabolic traits] |journal=Zhonghua Yi Xue Yi Chuan Xue Za Zhi |volume=18 |issue= 6 |pages= 426-30 |year= 2002 |pmid= 11774208 |doi=  }}
*{{cite journal  | author=Daimon M |title=Calpain 10 gene polymorphisms are related, not to type 2 diabetes, but to increased serum cholesterol in Japanese |journal=Diabetes Res. Clin. Pract. |volume=56 |issue= 2 |pages= 147–52 |year= 2002 |pmid= 11891023 |doi=10.1016/S0168-8227(01)00372-2  |name-list-format=vanc| author2=Oizumi T  | author3=Saitoh T  | display-authors=3  | last4=Kameda  | first4=W  | last5=Yamaguchi  | first5=H  | last6=Ohnuma  | first6=H  | last7=Igarashi  | first7=M  | last8=Manaka  | first8=H  | last9=Kato  | first9=T  }}
*{{cite journal | author=Elbein SC, Chu W, Ren Q, ''et al.'' |title=Role of calpain-10 gene variants in familial type 2 diabetes in Caucasians. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 2 |pages= 650-4 |year= 2002 |pmid= 11836299 |doi=  }}
*{{cite journal  | author=Fullerton SM |title=Geographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locus |journal=Am. J. Hum. Genet. |volume=70 |issue= 5 |pages= 1096–106 |year= 2002 |pmid= 11891618 |doi=10.1086/339930  | pmc=447588  |name-list-format=vanc| author2=Bartoszewicz A  | author3=Ybazeta G  | display-authors=3  | last4=Horikawa  | first4=Yukio  | last5=Bell  | first5=Graeme I.  | last6=Kidd  | first6=Kenneth K.  | last7=Cox  | first7=Nancy J.  | last8=Hudson  | first8=Richard R.  | last9=Di Rienzo  | first9=Anna  }}
*{{cite journal  | author=Daimon M, Oizumi T, Saitoh T, ''et al.'' |title=Calpain 10 gene polymorphisms are related, not to type 2 diabetes, but to increased serum cholesterol in Japanese. |journal=Diabetes Res. Clin. Pract. |volume=56 |issue= 2 |pages= 147-52 |year= 2002 |pmid= 11891023 |doi= }}
*{{cite journal  | author=Hoffstedt J |title=Polymorphism in the Calpain 10 gene influences glucose metabolism in human fat cells |journal=Diabetologia |volume=45 |issue= 2 |pages= 276–82 |year= 2002 |pmid= 11935160 |doi= 10.1007/s00125-001-0732-2  |name-list-format=vanc| author2=Rydén M  | author3=Löfgren P  | display-authors=3  | last4=Orho-Melander  | first4=M.  | last5=Groop  | first5=L.  | last6=Arner  | first6=P. }}
*{{cite journal  | author=Fullerton SM, Bartoszewicz A, Ybazeta G, ''et al.'' |title=Geographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locus. |journal=Am. J. Hum. Genet. |volume=70 |issue= 5 |pages= 1096-106 |year= 2002 |pmid= 11891618 |doi=  }}
*{{cite journal  | author=Malecki MT |title=Homozygous combination of calpain 10 gene haplotypes is associated with type 2 diabetes mellitus in a Polish population |journal=Eur. J. Endocrinol. |volume=146 |issue= 5 |pages= 695–9 |year= 2002 |pmid= 11980626 |doi=10.1530/eje.0.1460695  |name-list-format=vanc| author2=Moczulski DK  | author3=Klupa T  | display-authors=3  | last4=Wanic  | first4=K  | last5=Cyganek  | first5=K  | last6=Frey  | first6=J  | last7=Sieradzki  | first7=J  }}
*{{cite journal | author=Hoffstedt J, Rydén M, Löfgren P, ''et al.'' |title=Polymorphism in the Calpain 10 gene influences glucose metabolism in human fat cells. |journal=Diabetologia |volume=45 |issue= 2 |pages= 276-82 |year= 2002 |pmid= 11935160 |doi= 10.1007/s00125-001-0732-2 }}
*{{cite journal  | author=Sun HX |title=Single nucleotide polymorphisms in CAPN10 gene of Chinese people and its correlation with type 2 diabetes mellitus in Han people of northern China |journal=Biomed. Environ. Sci. |volume=15 |issue= 1 |pages= 75–82 |year= 2002 |pmid= 12046551 |doi=  |name-list-format=vanc| author2=Zhang KX  | author3=Du WN  | display-authors=3  | last4=Shi  | first4=JX  | last5=Jiang  | first5=ZW  | last6=Sun  | first6=H  | last7=Zuo  | first7=J  | last8=Huang  | first8=W  | last9=Chen  | first9=Z  }}
*{{cite journal | author=Malecki MT, Moczulski DK, Klupa T, ''et al.'' |title=Homozygous combination of calpain 10 gene haplotypes is associated with type 2 diabetes mellitus in a Polish population. |journal=Eur. J. Endocrinol. |volume=146 |issue= 5 |pages= 695-9 |year= 2002 |pmid= 11980626 |doi=  }}
*{{cite journal  | author=Haddad L |title=Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 6 |pages= 2606–10 |year= 2002 |pmid= 12050223 |doi=10.1210/jc.87.6.2606  |name-list-format=vanc| author2=Evans JC  | author3=Gharani N  | display-authors=3  | last4=Robertson  | first4=C  | last5=Rush  | first5=K  | last6=Wiltshire  | first6=S  | last7=Frayling  | first7=TM  | last8=Wilkin  | first8=TJ  | last9=Demaine  | first9=A }}
*{{cite journal  | author=Sun HX, Zhang KX, Du WN, ''et al.'' |title=Single nucleotide polymorphisms in CAPN10 gene of Chinese people and its correlation with type 2 diabetes mellitus in Han people of northern China. |journal=Biomed. Environ. Sci. |volume=15 |issue= 1 |pages= 75-82 |year= 2002 |pmid= 12046551 |doi=  }}
*{{cite journal  | author=Haddad L, Evans JC, Gharani N, ''et al.'' |title=Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 6 |pages= 2606-10 |year= 2002 |pmid= 12050223 |doi=  }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* The [[MEROPS]] online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=C02.018 C02.018]
* {{UCSC gene info|CAPN10}}
 
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{{Cysteine proteases}}
 
 
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Latest revision as of 09:11, 30 August 2017

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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RefSeq (mRNA)

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Wikidata
View/Edit Human

Calpain-10 is a protein that in humans is encoded by the CAPN10 gene.[1][2]

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The typical calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. The heterodimer interface is predominantly found between domain IV and the small subunit, which is also a calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It therefore cannot heterodimerize with the small subunit. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene.[3]

References

  1. ↑ Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, Hinokio Y, Lindner TH, Mashima H, Schwarz PE, del Bosque-Plata L, Horikawa Y, Oda Y, Yoshiuchi I, Colilla S, Polonsky KS, Wei S, Concannon P, Iwasaki N, Schulze J, Baier LJ, Bogardus C, Groop L, Boerwinkle E, Hanis CL, Bell GI (Nov 2000). "Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus". Nat Genet. 26 (2): 163–75. doi:10.1038/79876. PMID 11017071.
  2. ↑ Baier LJ, Permana PA, Yang X, Pratley RE, Hanson RL, Shen GQ, Mott D, Knowler WC, Cox NJ, Horikawa Y, Oda N, Bell GI, Bogardus C (Oct 2000). "A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance". J Clin Invest. 106 (7): R69–73. doi:10.1172/JCI10665. PMC 387246. PMID 11018080.
  3. ↑ "Entrez Gene: CAPN10 calpain 10".

Further reading

External links



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