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{{Infobox_gene}}
{{PBB_Controls
'''Centromere protein M''' also known as '''proliferation associated nuclear element 1''' (PANE1)  is a [[protein]] that in humans is encoded by the ''CENPM'' [[gene]].<ref name="pmid16622420">{{cite journal | vauthors = Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T | title = The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres | journal = Nature Cell Biology | volume = 8 | issue = 5 | pages = 446–57 | date = May 2006 | pmid = 16622420 | pmc =  | doi = 10.1038/ncb1396 }}</ref><ref name="pmid16622419">{{cite journal | vauthors = Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW | title = The human CENP-A centromeric nucleosome-associated complex | journal = Nature Cell Biology | volume = 8 | issue = 5 | pages = 458–69 | date = May 2006 | pmid = 16622419 | pmc =  | doi = 10.1038/ncb1397 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CENPM centromere protein M| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79019| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
An alternative transcript of the CENPM gene encodes a [[leukocyte]] [[antigen]] that is selectively expressed in [[B cell|B-lymphoid cell]]s.<ref name="pmid16391015">{{cite journal | vauthors = Brickner AG, Evans AM, Mito JK, Xuereb SM, Feng X, Nishida T, Fairfull L, Ferrell RE, Foon KA, Hunt DF, Shabanowitz J, Engelhard VH, Riddell SR, Warren EH | title = The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL | journal = Blood | volume = 107 | issue = 9 | pages = 3779–86 | year = 2006 | pmid = 16391015 | pmc = 1895781 | doi = 10.1182/blood-2005-08-3501 }}</ref><ref>{{cite journal | vauthors = Bierie B, Edwin M, Melenhorst JJ, Hennighausen L | title = The proliferation associated nuclear element (PANE1) is conserved between mammals and fish and preferentially expressed in activated lymphoid cells | journal = Gene Expression Patterns | volume = 4 | issue = 4 | pages = 389–95 | date = July 2004 | pmid = 15183305 | doi = 10.1016/j.modgep.2004.01.008 }}</ref> Centromere protein M us involved in [[centromere]] assembly and [[immune response]].<ref name="pmid19711193">{{cite journal | vauthors = Huang H, Deng H, Yang Y, Tang Z, Yang S, Mu Y, Cui W, Yuan J, Wu Z, Li K | title = Molecular characterization and association analysis of porcine PANE1 gene | journal = Molecular Biology Reports | volume = 37 | issue = 5 | pages = 2571–7 | year = 2010 | pmid = 19711193 | doi = 10.1007/s11033-009-9775-0 }}</ref>
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Centromere protein M
| HGNCid = 18352
| Symbol = CENPM
| AltSymbols =; C22orf18; CENP-M; MGC861; PANE1; bK250D10.2
| OMIM = 610152
| ECnumber =
| Homologene = 11438
| MGIid = 1913820
| GeneAtlas_image1 = PBB_GE_CENPM_218741_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0000775 |text = chromosome, pericentric region}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
| Process =  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 79019
    | Hs_Ensembl = ENSG00000100162
    | Hs_RefseqProtein = NP_001002876
    | Hs_RefseqmRNA = NM_001002876
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 40665006
    | Hs_GenLoc_end = 40673026
    | Hs_Uniprot = Q9NSP4
    | Mm_EntrezGene = 66570
    | Mm_Ensembl = ENSMUSG00000068101
    | Mm_RefseqmRNA = NM_001080158
    | Mm_RefseqProtein = NP_001073627
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 82061848
    | Mm_GenLoc_end = 82072513
    | Mm_Uniprot = Q9CQA0
  }}
}}
'''Centromere protein M''', also known as '''CENPM''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CENPM centromere protein M| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79019| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== References ==
{{PBB_Summary
{{reflist}}
| section_title =
| summary_text =
}}


==References==
== Further reading ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K | title = Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase | journal = Genes to Cells | volume = 9 | issue = 2 | pages = 105–20 | date = February 2004 | pmid = 15009096 | doi = 10.1111/j.1365-2443.2004.00705.x }}
| citations =
* {{cite journal | vauthors = Izuta H, Ikeno M, Suzuki N, Tomonaga T, Nozaki N, Obuse C, Kisu Y, Goshima N, Nomura F, Nomura N, Yoda K | title = Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells | journal = Genes to Cells | volume = 11 | issue = 6 | pages = 673–84 | date = June 2006 | pmid = 16716197 | doi = 10.1111/j.1365-2443.2006.00969.x }}
*{{cite journal  | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Collins JE, Goward ME, Cole CG, ''et al.'' |title=Reevaluating human gene annotation: a second-generation analysis of chromosome 22. |journal=Genome Res. |volume=13 |issue= 1 |pages= 27-36 |year= 2003 |pmid= 12529303 |doi= 10.1101/gr.695703 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Obuse C, Yang H, Nozaki N, ''et al.'' |title=Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase. |journal=Genes Cells |volume=9 |issue= 2 |pages= 105-20 |year= 2004 |pmid= 15009096 |doi=  }}
*{{cite journal  | author=Bierie B, Edwin M, Melenhorst JJ, Hennighausen L |title=The proliferation associated nuclear element (PANE1) is conserved between mammals and fish and preferentially expressed in activated lymphoid cells. |journal=Gene Expr. Patterns |volume=4 |issue= 4 |pages= 389-95 |year= 2005 |pmid= 15183305 |doi= 10.1016/j.modgep.2004.01.008 }}
*{{cite journal  | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Brickner AG, Evans AM, Mito JK, ''et al.'' |title=The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL. |journal=Blood |volume=107 |issue= 9 |pages= 3779-86 |year= 2006 |pmid= 16391015 |doi= 10.1182/blood-2005-08-3501 }}
*{{cite journal  | author=Foltz DR, Jansen LE, Black BE, ''et al.'' |title=The human CENP-A centromeric nucleosome-associated complex. |journal=Nat. Cell Biol. |volume=8 |issue= 5 |pages= 458-69 |year= 2006 |pmid= 16622419 |doi= 10.1038/ncb1397 }}
*{{cite journal  | author=Okada M, Cheeseman IM, Hori T, ''et al.'' |title=The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. |journal=Nat. Cell Biol. |volume=8 |issue= 5 |pages= 446-57 |year= 2006 |pmid= 16622420 |doi= 10.1038/ncb1396 }}
*{{cite journal  | author=Izuta H, Ikeno M, Suzuki N, ''et al.'' |title=Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. |journal=Genes Cells |volume=11 |issue= 6 |pages= 673-84 |year= 2006 |pmid= 16716197 |doi= 10.1111/j.1365-2443.2006.00969.x }}
}}
{{refend}}
{{refend}}
== External links ==
* {{UCSC gene info|CENPM}}
{{Chromosome genetics}}


{{gene-22-stub}}
{{gene-22-stub}}
{{Chromosome genetics}}
{{WikiDoc Sources}}

Latest revision as of 05:17, 2 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Centromere protein M also known as proliferation associated nuclear element 1 (PANE1) is a protein that in humans is encoded by the CENPM gene.[1][2][3]

An alternative transcript of the CENPM gene encodes a leukocyte antigen that is selectively expressed in B-lymphoid cells.[4][5] Centromere protein M us involved in centromere assembly and immune response.[6]

References

  1. ↑ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nature Cell Biology. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420.
  2. ↑ Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nature Cell Biology. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419.
  3. ↑ "Entrez Gene: CENPM centromere protein M".
  4. ↑ Brickner AG, Evans AM, Mito JK, Xuereb SM, Feng X, Nishida T, Fairfull L, Ferrell RE, Foon KA, Hunt DF, Shabanowitz J, Engelhard VH, Riddell SR, Warren EH (2006). "The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL". Blood. 107 (9): 3779–86. doi:10.1182/blood-2005-08-3501. PMC 1895781. PMID 16391015.
  5. ↑ Bierie B, Edwin M, Melenhorst JJ, Hennighausen L (July 2004). "The proliferation associated nuclear element (PANE1) is conserved between mammals and fish and preferentially expressed in activated lymphoid cells". Gene Expression Patterns. 4 (4): 389–95. doi:10.1016/j.modgep.2004.01.008. PMID 15183305.
  6. ↑ Huang H, Deng H, Yang Y, Tang Z, Yang S, Mu Y, Cui W, Yuan J, Wu Z, Li K (2010). "Molecular characterization and association analysis of porcine PANE1 gene". Molecular Biology Reports. 37 (5): 2571–7. doi:10.1007/s11033-009-9775-0. PMID 19711193.

Further reading

  • Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (February 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes to Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096.
  • Izuta H, Ikeno M, Suzuki N, Tomonaga T, Nozaki N, Obuse C, Kisu Y, Goshima N, Nomura F, Nomura N, Yoda K (June 2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes to Cells. 11 (6): 673–84. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197.

External links


Retrieved from "https://www.wikidoc.org/index.php?title=CENPM&oldid=1420030"