CHD1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Chromodomain-helicase-DNA-binding protein 1''' is an [[enzyme]] that in humans is encoded by the ''CHD1'' [[gene]].<ref name="pmid8460153">{{cite journal | vauthors = Delmas V, Stokes DG, Perry RP | title = A mammalian DNA-binding protein that contains a chromodomain and an SNF2/SWI2-like helicase domain | journal = Proc Natl Acad Sci U S A | volume = 90 | issue = 6 | pages = 2414–8 |date=Apr 1993 | pmid = 8460153 | pmc = 46097 | doi =10.1073/pnas.90.6.2414 }}</ref><ref name="pmid9326634">{{cite journal | vauthors = Woodage T, Basrai MA, Baxevanis AD, Hieter P, Collins FS | title = Characterization of the CHD family of proteins | journal = Proc Natl Acad Sci U S A | volume = 94 | issue = 21 | pages = 11472–7 |date=Nov 1997 | pmid = 9326634 | pmc = 23509 | doi =10.1073/pnas.94.21.11472 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CHD1 chromodomain helicase DNA binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1105| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CHD1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2b2t.
| PDB = {{PDB2|2b2t}}, {{PDB2|2b2u}}, {{PDB2|2b2v}}, {{PDB2|2b2w}}, {{PDB2|2b2y}}
| Name = Chromodomain helicase DNA binding protein 1
| HGNCid = 1915
| Symbol = CHD1
| AltSymbols =; DKFZp686E2337
| OMIM = 602118
| ECnumber =
| Homologene = 86052
| MGIid = 88393
| GeneAtlas_image1 = PBB_GE_CHD1_204258_at_tn.png
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0004003 |text = ATP-dependent DNA helicase activity}} {{GNF_GO|id=GO:0004386 |text = helicase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006333 |text = chromatin assembly or disassembly}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007001 |text = chromosome organization and biogenesis (sensu Eukaryota)}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1105
    | Hs_Ensembl = ENSG00000153922
    | Hs_RefseqProtein = NP_001261
    | Hs_RefseqmRNA = NM_001270
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 98218819
    | Hs_GenLoc_end = 98290138
    | Hs_Uniprot = O14646
    | Mm_EntrezGene = 12648
    | Mm_Ensembl = ENSMUSG00000023852
    | Mm_RefseqmRNA = NM_007690
    | Mm_RefseqProtein = NP_031716
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 15409664
    | Mm_GenLoc_end = 15475013
    | Mm_Uniprot = Q14BJ0
  }}
}}
'''Chromodomain helicase DNA binding protein 1''', also known as '''CHD1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CHD1 chromodomain helicase DNA binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1105| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains.  CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template.<ref name="entrez">{{cite web | title = Entrez Gene: CHD1 chromodomain helicase DNA binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1105| accessdate = }}</ref>
| summary_text = The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains.  CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template.<ref name="entrez" />
}}
}}
==Interactions==
CHD1 has been shown to [[Protein-protein interaction|interact]] with [[Nuclear receptor co-repressor 1]].<ref name=pmid12890497>{{cite journal |last=Tai |first=Helen H |author2=Geisterfer Margit |author3=Bell John C |author4=Moniwa Mariko |author5=Davie James R |author6=Boucher Lorrie |author7=McBurney Michael W  |date=Aug 2003 |title=CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue=1 |pages=170–6 |publisher= |location = United States| issn = 0006-291X| pmid = 12890497 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0006-291X(03)01354-8 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CHD1}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Stokes DG, Perry RP |title=DNA-binding and chromatin localization properties of CHD1. |journal=Mol. Cell. Biol. |volume=15 |issue= 5 |pages= 2745-53 |year= 1995 |pmid= 7739555 |doi=  }}
*{{cite journal  | vauthors=Stokes DG, Perry RP |title=DNA-binding and chromatin localization properties of CHD1 |journal=Mol. Cell. Biol. |volume=15 |issue= 5 |pages= 2745–53 |year= 1995 |pmid= 7739555 |doi=  | pmc=230505 }}
*{{cite journal  | author=Delmas V, Stokes DG, Perry RP |title=A mammalian DNA-binding protein that contains a chromodomain and an SNF2/SWI2-like helicase domain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 6 |pages= 2414-8 |year= 1993 |pmid= 8460153 |doi=  }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal  | vauthors=Kelley DE, Stokes DG, Perry RP |title=CHD1 interacts with SSRP1 and depends on both its chromodomain and its ATPase/helicase-like domain for proper association with chromatin |journal=Chromosoma |volume=108 |issue= 1 |pages= 10–25 |year= 1999 |pmid= 10199952 |doi=10.1007/s004120050347 }}
*{{cite journal  | author=Woodage T, Basrai MA, Baxevanis AD, ''et al.'' |title=Characterization of the CHD family of proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 21 |pages= 11472-7 |year= 1997 |pmid= 9326634 |doi= }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Kelley DE, Stokes DG, Perry RP |title=CHD1 interacts with SSRP1 and depends on both its chromodomain and its ATPase/helicase-like domain for proper association with chromatin. |journal=Chromosoma |volume=108 |issue= 1 |pages= 10-25 |year= 1999 |pmid= 10199952 |doi=  }}
*{{cite journal  | vauthors=Salomon AR, Ficarro SB, Brill LM |title=Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 2 |pages= 443–8 |year= 2003 |pmid= 12522270 |doi= 10.1073/pnas.2436191100 | pmc=141014 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Tai HH, Geisterfer M, Bell JC |title=CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 1 |pages= 170–6 |year= 2003 |pmid= 12890497 |doi=10.1016/S0006-291X(03)01354-8 |display-authors=etal}}
*{{cite journal  | author=Salomon AR, Ficarro SB, Brill LM, ''et al.'' |title=Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 2 |pages= 443-8 |year= 2003 |pmid= 12522270 |doi= 10.1073/pnas.2436191100 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Tai HH, Geisterfer M, Bell JC, ''et al.'' |title=CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins. |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 1 |pages= 170-6 |year= 2003 |pmid= 12890497 |doi=  }}
*{{cite journal  | vauthors=Brandenberger R, Wei H, Zhang S |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Sims RJ, Chen CF, Santos-Rosa H |title=HUMAN BUT NOT YEAST CHD1 BINDS DIRECTLY AND SELECTIVELY TO HISTONE H3 METHYLATED AT LYSINE 4 VIA ITS TANDEM CHROMODOMAINS |journal=J. Biol. Chem. |volume=280 |issue= 51 |pages= 41789–92 |year= 2006 |pmid= 16263726 |doi= 10.1074/jbc.C500395200 | pmc=1421377 |display-authors=etal}}
*{{cite journal  | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal  | vauthors=Flanagan JF, Mi LZ, Chruszcz M |title=Double chromodomains cooperate to recognize the methylated histone H3 tail |journal=Nature |volume=438 |issue= 7071 |pages= 1181–5 |year= 2006 |pmid= 16372014 |doi= 10.1038/nature04290 |display-authors=etal}}
*{{cite journal  | author=Sims RJ, Chen CF, Santos-Rosa H, ''et al.'' |title=Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. |journal=J. Biol. Chem. |volume=280 |issue= 51 |pages= 41789-92 |year= 2006 |pmid= 16263726 |doi= 10.1074/jbc.C500395200 }}
*{{cite journal  | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
*{{cite journal  | author=Flanagan JF, Mi LZ, Chruszcz M, ''et al.'' |title=Double chromodomains cooperate to recognize the methylated histone H3 tail. |journal=Nature |volume=438 |issue= 7071 |pages= 1181-5 |year= 2006 |pmid= 16372014 |doi= 10.1038/nature04290 }}
*{{cite journal  | vauthors=Okuda M, Horikoshi M, Nishimura Y |title=Structural polymorphism of chromodomains in Chd1 |journal=J. Mol. Biol. |volume=365 |issue= 4 |pages= 1047–62 |year= 2007 |pmid= 17098252 |doi= 10.1016/j.jmb.2006.10.039 }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}
*{{cite journal  | author=Okuda M, Horikoshi M, Nishimura Y |title=Structural polymorphism of chromodomains in Chd1. |journal=J. Mol. Biol. |volume=365 |issue= 4 |pages= 1047-62 |year= 2007 |pmid= 17098252 |doi= 10.1016/j.jmb.2006.10.039 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=1105}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


{{protein-stub}}
{{gene-5-stub}}
{{WikiDoc Sources}}

Revision as of 09:38, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Chromodomain-helicase-DNA-binding protein 1 is an enzyme that in humans is encoded by the CHD1 gene.[1][2][3]

The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template.[3]

Interactions

CHD1 has been shown to interact with Nuclear receptor co-repressor 1.[4]

References

  1. ↑ Delmas V, Stokes DG, Perry RP (Apr 1993). "A mammalian DNA-binding protein that contains a chromodomain and an SNF2/SWI2-like helicase domain". Proc Natl Acad Sci U S A. 90 (6): 2414–8. doi:10.1073/pnas.90.6.2414. PMC 46097. PMID 8460153.
  2. ↑ Woodage T, Basrai MA, Baxevanis AD, Hieter P, Collins FS (Nov 1997). "Characterization of the CHD family of proteins". Proc Natl Acad Sci U S A. 94 (21): 11472–7. doi:10.1073/pnas.94.21.11472. PMC 23509. PMID 9326634.
  3. ↑ 3.0 3.1 "Entrez Gene: CHD1 chromodomain helicase DNA binding protein 1".
  4. ↑ Tai, Helen H; Geisterfer Margit; Bell John C; Moniwa Mariko; Davie James R; Boucher Lorrie; McBurney Michael W (Aug 2003). "CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins". Biochem. Biophys. Res. Commun. United States. 308 (1): 170–6. doi:10.1016/S0006-291X(03)01354-8. ISSN 0006-291X. PMID 12890497.

External links

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=CHD1&oldid=1420494"