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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Cullin-3''' is a [[protein]] that in humans is encoded by the ''CUL3'' [[gene]].<ref name="pmid8681378">{{cite journal | vauthors = Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM | title = cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family | journal = Cell | volume = 85 | issue = 6 | pages = 829–39 | date = Jun 1996 | pmid = 8681378 | pmc =  | doi = 10.1016/S0092-8674(00)81267-2 }}</ref><ref name="pmid17192413">{{cite journal | vauthors = Wimuttisuk W, Singer JD | title = The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer | journal = Molecular Biology of the Cell | volume = 18 | issue = 3 | pages = 899–909 | date = Mar 2007 | pmid = 17192413 | pmc = 1805106 | doi = 10.1091/mbc.E06-06-0542 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CUL3 cullin 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8452| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_CUL3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1iuy.
| PDB = {{PDB2|1iuy}}
| Name = Cullin 3
| HGNCid = 2553
| Symbol = CUL3
| AltSymbols =;
| OMIM = 603136
| ECnumber = 
| Homologene = 2661
| MGIid = 1347360
| GeneAtlas_image1 = PBB_GE_CUL3_201371_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CUL3_201370_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_CUL3_201372_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000082 |text = G1/S transition of mitotic cell cycle}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0008629 |text = induction of apoptosis by intracellular signals}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8452
    | Hs_Ensembl = ENSG00000036257
    | Hs_RefseqProtein = NP_003581
    | Hs_RefseqmRNA = NM_003590
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 225043113
    | Hs_GenLoc_end = 225158358
    | Hs_Uniprot = Q13618
    | Mm_EntrezGene = 26554
    | Mm_Ensembl = ENSMUSG00000004364
    | Mm_RefseqmRNA = XM_976272
    | Mm_RefseqProtein = XP_981366
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 80145842
    | Mm_GenLoc_end = 80219466
    | Mm_Uniprot = Q6ZQ84
  }}
}}
'''Cullin 3''', also known as '''CUL3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CUL3 cullin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8452| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
CUL3 has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
{{div col|colwidth=20em}}
| section_title =  
* [[CAND1]],<ref name = pmid12609982>{{cite journal | vauthors = Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB | title = TIP120A associates with cullins and modulates ubiquitin ligase activity | journal = The Journal of Biological Chemistry | volume = 278 | issue = 18 | pages = 15905–10 | date = May 2003 | pmid = 12609982 | doi = 10.1074/jbc.M213070200 }}</ref>
| summary_text =  
* [[Cyclin E1]],<ref name = pmid10500095>{{cite journal | vauthors = Singer JD, Gurian-West M, Clurman B, Roberts JM | title = Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells | journal = Genes & Development | volume = 13 | issue = 18 | pages = 2375–87 | date = Sep 1999 | pmid = 10500095 | pmc = 317026 | doi =  10.1101/gad.13.18.2375}}</ref>
}}
* [[DCUN1D1]],<ref name = pmid18826954>{{cite journal | vauthors = Kim AY, Bommeljé CC, Lee BE, Yonekawa Y, Choi L, Morris LG, Huang G, Kaufman A, Ryan RJ, Hao B, Ramanathan Y, Singh B | title = SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation | journal = The Journal of Biological Chemistry | volume = 283 | issue = 48 | pages = 33211–20 | date = Nov 2008 | pmid = 18826954 | pmc = 2586271 | doi = 10.1074/jbc.M804440200 }}</ref>
* [[KEAP1]],<ref name = pmid18417180>{{cite journal | vauthors = Wang XJ, Sun Z, Chen W, Li Y, Villeneuve NF, Zhang DD | title = Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction | journal = Toxicology and Applied Pharmacology | volume = 230 | issue = 3 | pages = 383–9 | date = Aug 2008 | pmid = 18417180 | pmc = 2610481 | doi = 10.1016/j.taap.2008.03.003 }}</ref><ref name = pmid18251510>{{cite journal | vauthors = Rachakonda G, Xiong Y, Sekhar KR, Stamer SL, Liebler DC, Freeman ML | title = Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3 | journal = Chemical Research in Toxicology | volume = 21 | issue = 3 | pages = 705–10 | date = Mar 2008 | pmid = 18251510 | doi = 10.1021/tx700302s }}</ref> and
* [[KLHL12]].<ref name = pmid18303015>{{cite journal | vauthors = Rondou P, Haegeman G, Vanhoenacker P, Van Craenenbroeck K | title = BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase | journal = The Journal of Biological Chemistry | volume = 283 | issue = 17 | pages = 11083–96 | date = Apr 2008 | pmid = 18303015 | pmc = 2431063 | doi = 10.1074/jbc.M708473200 }}</ref>
{{Div col end}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
==External links==
* {{UCSC gene info|CUL3}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Analytical Biochemistry | volume = 236 | issue = 1 | pages = 107–13 | date = Apr 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
| citations =
* {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Research | volume = 7 | issue = 4 | pages = 353–8 | date = Apr 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
* {{cite journal | vauthors = Michel JJ, Xiong Y | title = Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A | journal = Cell Growth & Differentiation | volume = 9 | issue = 6 | pages = 435–49 | date = Jun 1998 | pmid = 9663463 | doi =  }}
*{{cite journal | author=Kipreos ET, Lander LE, Wing JP, ''et al.'' |title=cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. |journal=Cell |volume=85 |issue= 6 |pages= 829-39 |year= 1996 |pmid= 8681378 |doi=  }}
* {{cite journal | vauthors = Du M, Sansores-Garcia L, Zu Z, Wu KK | title = Cloning and expression analysis of a novel salicylate suppressible gene, Hs-CUL-3, a member of cullin/Cdc53 family | journal = The Journal of Biological Chemistry | volume = 273 | issue = 38 | pages = 24289–92 | date = Sep 1998 | pmid = 9733711 | doi = 10.1074/jbc.273.38.24289 }}
*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi= }}
* {{cite journal | vauthors = Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 3 | pages = 169–76 | date = Jun 1998 | pmid = 9734811 | doi = 10.1093/dnares/5.3.169 }}
*{{cite journal | author=Michel JJ, Xiong Y |title=Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A. |journal=Cell Growth Differ. |volume=9 |issue= 6 |pages= 435-49 |year= 1998 |pmid= 9663463 |doi=  }}
* {{cite journal | vauthors = Ohta T, Michel JJ, Schottelius AJ, Xiong Y | title = ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity | journal = Molecular Cell | volume = 3 | issue = 4 | pages = 535–41 | date = Apr 1999 | pmid = 10230407 | doi = 10.1016/S1097-2765(00)80482-7 }}
*{{cite journal | author=Du M, Sansores-Garcia L, Zu Z, Wu KK |title=Cloning and expression analysis of a novel salicylate suppressible gene, Hs-CUL-3, a member of cullin/Cdc53 family. |journal=J. Biol. Chem. |volume=273 |issue= 38 |pages= 24289-92 |year= 1998 |pmid= 9733711 |doi= }}
* {{cite journal | vauthors = Singer JD, Gurian-West M, Clurman B, Roberts JM | title = Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells | journal = Genes & Development | volume = 13 | issue = 18 | pages = 2375–87 | date = Sep 1999 | pmid = 10500095 | pmc = 317026 | doi = 10.1101/gad.13.18.2375 }}
*{{cite journal | author=Ishikawa K, Nagase T, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 3 |pages= 169-76 |year= 1998 |pmid= 9734811 |doi= }}
* {{cite journal | vauthors = Hori T, Osaka F, Chiba T, Miyamoto C, Okabayashi K, Shimbara N, Kato S, Tanaka K | title = Covalent modification of all members of human cullin family proteins by NEDD8 | journal = Oncogene | volume = 18 | issue = 48 | pages = 6829–34 | date = Nov 1999 | pmid = 10597293 | doi = 10.1038/sj.onc.1203093 }}
*{{cite journal | author=Ohta T, Michel JJ, Schottelius AJ, Xiong Y |title=ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. |journal=Mol. Cell |volume=3 |issue= 4 |pages= 535-41 |year= 1999 |pmid= 10230407 |doi= }}
* {{cite journal | vauthors = Maeda I, Ohta T, Koizumi H, Fukuda M | title = In vitro ubiquitination of cyclin D1 by ROC1-CUL1 and ROC1-CUL3 | journal = FEBS Letters | volume = 494 | issue = 3 | pages = 181–5 | date = Apr 2001 | pmid = 11311237 | doi = 10.1016/S0014-5793(01)02343-2 }}
*{{cite journal | author=Singer JD, Gurian-West M, Clurman B, Roberts JM |title=Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. |journal=Genes Dev. |volume=13 |issue= 18 |pages= 2375-87 |year= 1999 |pmid= 10500095 |doi= }}
* {{cite journal | vauthors = Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ | title = Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome | journal = Science | volume = 292 | issue = 5520 | pages = 1382–5 | date = May 2001 | pmid = 11337588 | doi = 10.1126/science.1059780 }}
*{{cite journal | author=Hori T, Osaka F, Chiba T, ''et al.'' |title=Covalent modification of all members of human cullin family proteins by NEDD8. |journal=Oncogene |volume=18 |issue= 48 |pages= 6829-34 |year= 2000 |pmid= 10597293 |doi= 10.1038/sj.onc.1203093 }}
* {{cite journal | vauthors = Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB | title = TIP120A associates with cullins and modulates ubiquitin ligase activity | journal = The Journal of Biological Chemistry | volume = 278 | issue = 18 | pages = 15905–10 | date = May 2003 | pmid = 12609982 | doi = 10.1074/jbc.M213070200 }}
*{{cite journal | author=Maeda I, Ohta T, Koizumi H, Fukuda M |title=In vitro ubiquitination of cyclin D1 by ROC1-CUL1 and ROC1-CUL3. |journal=FEBS Lett. |volume=494 |issue= 3 |pages= 181-5 |year= 2001 |pmid= 11311237 |doi= }}
* {{cite journal | vauthors = Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, Yamamoto M | title = Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 | journal = Molecular and Cellular Biology | volume = 24 | issue = 16 | pages = 7130–9 | date = Aug 2004 | pmid = 15282312 | pmc = 479737 | doi = 10.1128/MCB.24.16.7130-7139.2004 }}
*{{cite journal | author=Lyapina S, Cope G, Shevchenko A, ''et al.'' |title=Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. |journal=Science |volume=292 |issue= 5520 |pages= 1382-5 |year= 2001 |pmid= 11337588 |doi= 10.1126/science.1059780 }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nature Biotechnology | volume = 23 | issue = 1 | pages = 94–101 | date = Jan 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 }}
*{{cite journal  | author=Min KW, Hwang JW, Lee JS, ''et al.'' |title=TIP120A associates with cullins and modulates ubiquitin ligase activity. |journal=J. Biol. Chem. |volume=278 |issue= 18 |pages= 15905-10 |year= 2003 |pmid= 12609982 |doi= 10.1074/jbc.M213070200 }}
* {{cite journal | vauthors = Furukawa M, Xiong Y | title = BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase | journal = Molecular and Cellular Biology | volume = 25 | issue = 1 | pages = 162–71 | date = Jan 2005 | pmid = 15601839 | pmc = 538799 | doi = 10.1128/MCB.25.1.162-171.2005 }}
*{{cite journal | author=Kobayashi A, Kang MI, Okawa H, ''et al.'' |title=Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. |journal=Mol. Cell. Biol. |volume=24 |issue= 16 |pages= 7130-9 |year= 2004 |pmid= 15282312 |doi= 10.1128/MCB.24.16.7130-7139.2004 }}
* {{cite journal | vauthors = Hernández-Muñoz I, Lund AH, van der Stoop P, Boutsma E, Muijrers I, Verhoeven E, Nusinow DA, Panning B, Marahrens Y, van Lohuizen M | title = Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 102 | issue = 21 | pages = 7635–40 | date = May 2005 | pmid = 15897469 | pmc = 1140410 | doi = 10.1073/pnas.0408918102 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
* {{cite journal | vauthors = Lu L, Zhou ZM, Huang XY, Xu M, Yin LL, Wang H, Xu ZY, Sha JH | title = Identification and characterization of cul-3b, a novel hominine CUL-3 transcript variant | journal = Asian Journal of Andrology | volume = 7 | issue = 2 | pages = 205–11 | date = Jun 2005 | pmid = 15897978 | doi = 10.1111/j.1745-7262.2005.00024.x }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal | author=Furukawa M, Xiong Y |title=BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. |journal=Mol. Cell. Biol. |volume=25 |issue= 1 |pages= 162-71 |year= 2005 |pmid= 15601839 |doi= 10.1128/MCB.25.1.162-171.2005 }}
*{{cite journal | author=Hernández-Muñoz I, Lund AH, van der Stoop P, ''et al.'' |title=Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 21 |pages= 7635-40 |year= 2005 |pmid= 15897469 |doi= 10.1073/pnas.0408918102 }}
*{{cite journal | author=Lu L, Zhou ZM, Huang XY, ''et al.'' |title=Identification and characterization of cul-3b, a novel hominine CUL-3 transcript variant. |journal=Asian J. Androl. |volume=7 |issue= 2 |pages= 205-11 |year= 2005 |pmid= 15897978 |doi= 10.1111/j.1745-7262.2005.00024.x }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=8452}}
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{{gene-2-stub}}

Revision as of 10:11, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cullin-3 is a protein that in humans is encoded by the CUL3 gene.[1][2][3]

Interactions

CUL3 has been shown to interact with:

References

  1. ↑ Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM (Jun 1996). "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family". Cell. 85 (6): 829–39. doi:10.1016/S0092-8674(00)81267-2. PMID 8681378.
  2. ↑ Wimuttisuk W, Singer JD (Mar 2007). "The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer". Molecular Biology of the Cell. 18 (3): 899–909. doi:10.1091/mbc.E06-06-0542. PMC 1805106. PMID 17192413.
  3. ↑ "Entrez Gene: CUL3 cullin 3".
  4. ↑ Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB (May 2003). "TIP120A associates with cullins and modulates ubiquitin ligase activity". The Journal of Biological Chemistry. 278 (18): 15905–10. doi:10.1074/jbc.M213070200. PMID 12609982.
  5. ↑ Singer JD, Gurian-West M, Clurman B, Roberts JM (Sep 1999). "Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells". Genes & Development. 13 (18): 2375–87. doi:10.1101/gad.13.18.2375. PMC 317026. PMID 10500095.
  6. ↑ Kim AY, Bommeljé CC, Lee BE, Yonekawa Y, Choi L, Morris LG, Huang G, Kaufman A, Ryan RJ, Hao B, Ramanathan Y, Singh B (Nov 2008). "SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation". The Journal of Biological Chemistry. 283 (48): 33211–20. doi:10.1074/jbc.M804440200. PMC 2586271. PMID 18826954.
  7. ↑ Wang XJ, Sun Z, Chen W, Li Y, Villeneuve NF, Zhang DD (Aug 2008). "Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction". Toxicology and Applied Pharmacology. 230 (3): 383–9. doi:10.1016/j.taap.2008.03.003. PMC 2610481. PMID 18417180.
  8. ↑ Rachakonda G, Xiong Y, Sekhar KR, Stamer SL, Liebler DC, Freeman ML (Mar 2008). "Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3". Chemical Research in Toxicology. 21 (3): 705–10. doi:10.1021/tx700302s. PMID 18251510.
  9. ↑ Rondou P, Haegeman G, Vanhoenacker P, Van Craenenbroeck K (Apr 2008). "BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase". The Journal of Biological Chemistry. 283 (17): 11083–96. doi:10.1074/jbc.M708473200. PMC 2431063. PMID 18303015.

External links

Further reading

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