FGF14: Difference between revisions

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{{Infobox_gene}}
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'''Fibroblast growth factor 14''' is a [[protein]] that in humans is encoded by the ''FGF14'' [[gene]].<ref name="pmid8790420">{{cite journal |vauthors=Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SH, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J | title = Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development | journal = Proc Natl Acad Sci U S A | volume = 93 | issue = 18 | pages = 9850–7 |date=Oct 1996 | pmid = 8790420 | pmc = 38518 | doi =10.1073/pnas.93.18.9850  }}</ref><ref name="pmid17236779">{{cite journal |vauthors=Wozniak DF, Xiao M, Xu L, Yamada KA, Ornitz DM | title = Impaired spatial learning and defective theta burst induced LTP in mice lacking fibroblast growth factor 14 | journal = Neurobiol Dis | volume = 26 | issue = 1 | pages = 14–26 |date=Mar 2007 | pmid = 17236779 | pmc = 2267915 | doi = 10.1016/j.nbd.2006.11.014 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FGF14 fibroblast growth factor 14| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2259| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Fibroblast growth factor 14
| HGNCid = 3671
| Symbol = FGF14
| AltSymbols =; FHF4; MGC119129; SCA27
| OMIM = 601515
| ECnumber = 
| Homologene = 3037
| MGIid = 109189
| Function = {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0008219 |text = cell death}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2259
    | Hs_Ensembl = ENSG00000102466
    | Hs_RefseqProtein = NP_004106
    | Hs_RefseqmRNA = NM_004115
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 13
    | Hs_GenLoc_start = 101169308
    | Hs_GenLoc_end = 101852156
    | Hs_Uniprot = Q92915
    | Mm_EntrezGene = 14169
    | Mm_Ensembl = ENSMUSG00000025551
    | Mm_RefseqmRNA = NM_010201
    | Mm_RefseqProtein = NP_034331
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 123115526
    | Mm_GenLoc_end = 123859945
    | Mm_Uniprot = Q3KNZ6
  }}
}}
'''Fibroblast growth factor 14''', also known as '''FGF14''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FGF14 fibroblast growth factor 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2259| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including [[embryo|embryonic]] development, cell growth, morphogenesis, tissue repair, [[tumor]] growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: FGF14 fibroblast growth factor 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2259| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including [[embryo]]nic development, cell growth, morphogenesis, tissue repair, [[tumor]] growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Smallwood PM, Munoz-Sanjuan I, Tong P, ''et al.'' |title=Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 18 |pages= 9850-7 |year= 1996 |pmid= 8790420 |doi=  }}
*{{cite journal  | author=Wang Q |title=Ataxia and paroxysmal dyskinesia in mice lacking axonally transported FGF14 |journal=Neuron |volume=35 |issue= 1 |pages= 25–38 |year= 2002 |pmid= 12123606 |doi=10.1016/S0896-6273(02)00744-4 |name-list-format=vanc| author2=Bardgett ME | author3=Wong M | display-authors=3  | last4=Wozniak  | first4=David F. | last5=Lou  | first5=Junyang  | last6=McNeil  | first6=Benjamin D.  | last7=Chen  | first7=Chen  | last8=Nardi  | first8=Anthony  | last9=Reid  | first9=David C. }}
*{{cite journal  | author=Wang Q, Bardgett ME, Wong M, ''et al.'' |title=Ataxia and paroxysmal dyskinesia in mice lacking axonally transported FGF14. |journal=Neuron |volume=35 |issue= 1 |pages= 25-38 |year= 2002 |pmid= 12123606 |doi=  }}
*{{cite journal  | author=Chumakov I |title=Genetic and physiological data implicating the new human gene G72 and the gene for d-amino acid oxidase in schizophrenia |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 21 |pages= 13675–80 |year= 2002 |pmid= 12364586 |doi= 10.1073/pnas.182412499 | pmc=129739  |name-list-format=vanc| author2=Blumenfeld M  | author3=Guerassimenko O  | display-authors=3  | last4=Cavarec  | first4=L  | last5=Palicio  | first5=M  | last6=Abderrahim  | first6=H  | last7=Bougueleret  | first7=L  | last8=Barry  | first8=C  | last9=Tanaka  | first9=H }}
*{{cite journal  | author=Chumakov I, Blumenfeld M, Guerassimenko O, ''et al.'' |title=Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 21 |pages= 13675-80 |year= 2002 |pmid= 12364586 |doi= 10.1073/pnas.182412499 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=van Swieten JC |title=A Mutation in the Fibroblast Growth Factor 14 Gene Is Associated with Autosomal Dominant Cerebral Ataxia |journal=Am. J. Hum. Genet. |volume=72 |issue= 1 |pages= 191–9 |year= 2003 |pmid= 12489043 |doi=10.1086/345488  | pmc=378625  |name-list-format=vanc| author2=Brusse E  | author3=de Graaf BM  | display-authors=3  | last4=Krieger  | first4=Elmar  | last5=Van De Graaf  | first5=Raoul  | last6=De Koning  | first6=Inge  | last7=Maat-Kievit  | first7=Anneke  | last8=Leegwater  | first8=Peter  | last9=Dooijes  | first9=Dennis }}
*{{cite journal  | author=van Swieten JC, Brusse E, de Graaf BM, ''et al.'' |title=A mutation in the fibroblast growth factor 14 gene is associated with autosomal dominant cerebellar ataxia [corrected]. |journal=Am. J. Hum. Genet. |volume=72 |issue= 1 |pages= 191-9 |year= 2003 |pmid= 12489043 |doi=  }}
*{{cite journal  | author=Dunham A |title=The DNA sequence and analysis of human chromosome 13 |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 | pmc=2665288  |name-list-format=vanc| author2=Matthews LH  | author3=Burton J  | display-authors=3  | last4=Ashurst  | first4=J. L.  | last5=Howe  | first5=K. L.  | last6=Ashcroft  | first6=K. J.  | last7=Beare  | first7=D. M.  | last8=Burford  | first8=D. C.  | last9=Hunt  | first9=S. E. }}
*{{cite journal  | author=Dunham A, Matthews LH, Burton J, ''et al.'' |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522-8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 }}
*{{cite journal  |vauthors=Popovici C, Conchonaud F, Birnbaum D, Roubin R |title=Functional phylogeny relates LET-756 to fibroblast growth factor 9 |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 40146–52 |year= 2004 |pmid= 15199049 |doi= 10.1074/jbc.M405795200 }}
*{{cite journal  | author=Popovici C, Conchonaud F, Birnbaum D, Roubin R |title=Functional phylogeny relates LET-756 to fibroblast growth factor 9. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 40146-52 |year= 2004 |pmid= 15199049 |doi= 10.1074/jbc.M405795200 }}
*{{cite journal  | author=Stevanin G |title=Mutations in the FGF14 gene are not a major cause of spinocerebellar ataxia in Caucasians |journal=Neurology |volume=63 |issue= 5 |pages= 936 |year= 2005 |pmid= 15365159 |doi= 10.1212/01.wnl.0000137020.30604.1e|name-list-format=vanc| author2=Durr A  | author3=Dussert C  | display-authors=3  | last4=Penet  | first4=C  | last5=Brice  | first5=A }}
*{{cite journal  | author=Stevanin G, Durr A, Dussert C, ''et al.'' |title=Mutations in the FGF14 gene are not a major cause of spinocerebellar ataxia in Caucasians. |journal=Neurology |volume=63 |issue= 5 |pages= 936 |year= 2005 |pmid= 15365159 |doi=  }}
*{{cite journal  | author=Dalski A |title=Mutation analysis in the fibroblast growth factor 14 gene: frameshift mutation and polymorphisms in patients with inherited ataxias |journal=Eur. J. Hum. Genet. |volume=13 |issue= 1 |pages= 118–20 |year= 2005 |pmid= 15470364 |doi= 10.1038/sj.ejhg.5201286 |name-list-format=vanc| author2=Atici J  | author3=Kreuz FR  | display-authors=3  | last4=Hellenbroich  | first4=Yorck  | last5=Schwinger  | first5=Eberhard  | last6=Zühlke  | first6=Christine }}
*{{cite journal  | author=Dalski A, Atici J, Kreuz FR, ''et al.'' |title=Mutation analysis in the fibroblast growth factor 14 gene: frameshift mutation and polymorphisms in patients with inherited ataxias. |journal=Eur. J. Hum. Genet. |volume=13 |issue= 1 |pages= 118-20 |year= 2005 |pmid= 15470364 |doi= 10.1038/sj.ejhg.5201286 }}
*{{cite journal  | author=Lou JY |title=Fibroblast growth factor 14 is an intracellular modulator of voltage-gated sodium channels |journal=J. Physiol. |volume=569 |issue= Pt 1 |pages= 179–93 |year= 2006 |pmid= 16166153 |doi= 10.1113/jphysiol.2005.097220 | pmc=1464207  |name-list-format=vanc| author2=Laezza F  | author3=Gerber BR  | display-authors=3  | last4=Xiao  | first4=M  | last5=Yamada  | first5=KA  | last6=Hartmann  | first6=H  | last7=Craig  | first7=AM  | last8=Nerbonne  | first8=JM  | last9=Ornitz  | first9=DM }}
*{{cite journal  | author=Lou JY, Laezza F, Gerber BR, ''et al.'' |title=Fibroblast growth factor 14 is an intracellular modulator of voltage-gated sodium channels. |journal=J. Physiol. (Lond.) |volume=569 |issue= Pt 1 |pages= 179-93 |year= 2006 |pmid= 16166153 |doi= 10.1113/jphysiol.2005.097220 }}
*{{cite journal  | author=Brusse E |title=Spinocerebellar ataxia associated with a mutation in the fibroblast growth factor 14 gene (SCA27): A new phenotype |journal=Mov. Disord. |volume=21 |issue= 3 |pages= 396–401 |year= 2006 |pmid= 16211615 |doi= 10.1002/mds.20708 |name-list-format=vanc| author2=de Koning I  | author3=Maat-Kievit A  | display-authors=3  | last4=Oostra  | first4=Ben A.  | last5=Heutink  | first5=Peter  | last6=Van Swieten  | first6=John C. }}
*{{cite journal  | author=Brusse E, de Koning I, Maat-Kievit A, ''et al.'' |title=Spinocerebellar ataxia associated with a mutation in the fibroblast growth factor 14 gene (SCA27): A new phenotype. |journal=Mov. Disord. |volume=21 |issue= 3 |pages= 396-401 |year= 2006 |pmid= 16211615 |doi= 10.1002/mds.20708 }}
*{{cite journal  |vauthors=Zhao Y, Lim SW, Tan EK |title=Genetic analysis of SCA 27 in ataxia and childhood onset postural tremor |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=144 |issue= 3 |pages= 395–6 |year= 2007 |pmid= 17221845 |doi= 10.1002/ajmg.b.30472 }}
*{{cite journal  | author=Zhao Y, Lim SW, Tan EK |title=Genetic analysis of SCA 27 in ataxia and childhood onset postural tremor. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=144 |issue= 3 |pages= 395-6 |year= 2007 |pmid= 17221845 |doi= 10.1002/ajmg.b.30472 }}
*{{cite journal  | author=Wozniak DF, Xiao M, Xu L, ''et al.'' |title=Impaired spatial learning and defective theta burst induced LTP in mice lacking fibroblast growth factor 14. |journal=Neurobiol. Dis. |volume=26 |issue= 1 |pages= 14-26 |year= 2007 |pmid= 17236779 |doi= 10.1016/j.nbd.2006.11.014 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 04:46, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Fibroblast growth factor 14 is a protein that in humans is encoded by the FGF14 gene.[1][2][3]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene.[3]

References

  1. ↑ Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SH, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Oct 1996). "Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development". Proc Natl Acad Sci U S A. 93 (18): 9850–7. doi:10.1073/pnas.93.18.9850. PMC 38518. PMID 8790420.
  2. ↑ Wozniak DF, Xiao M, Xu L, Yamada KA, Ornitz DM (Mar 2007). "Impaired spatial learning and defective theta burst induced LTP in mice lacking fibroblast growth factor 14". Neurobiol Dis. 26 (1): 14–26. doi:10.1016/j.nbd.2006.11.014. PMC 2267915. PMID 17236779.
  3. ↑ 3.0 3.1 "Entrez Gene: FGF14 fibroblast growth factor 14".

Further reading



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