HNRNPA0: Difference between revisions

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{{Infobox_gene}}
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'''Heterogeneous nuclear ribonucleoprotein A0''' is a [[protein]] that in humans is encoded by the ''HNRNPA0'' [[gene]].<ref name="pmid7585247">{{cite journal |vauthors=Myer VE, Steitz JA | title = Isolation and characterization of a novel, low abundance hnRNP protein: A0 | journal = RNA | volume = 1 | issue = 2 | pages = 171–82 |date=Dec 1995 | pmid = 7585247 | pmc = 1369071 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HNRPA0 heterogeneous nuclear ribonucleoprotein A0| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10949| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Heterogeneous nuclear ribonucleoprotein A0
| HGNCid = 5030
| Symbol = HNRPA0
| AltSymbols =; hnRNPA0
| OMIM = 609409
| ECnumber = 
| Homologene = 74582
| MGIid = 1924384
| GeneAtlas_image1 = PBB_GE_HNRPA0_201055_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_HNRPA0_201054_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0030530 |text = heterogeneous nuclear ribonucleoprotein complex}}
| Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10949
    | Hs_Ensembl = ENSG00000177733
    | Hs_RefseqProtein = NP_006796
    | Hs_RefseqmRNA = NM_006805
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 137116737
    | Hs_GenLoc_end = 137117654
    | Hs_Uniprot = Q13151
    | Mm_EntrezGene = 77134
    | Mm_Ensembl = ENSMUSG00000007836
    | Mm_RefseqmRNA = XM_001001311
    | Mm_RefseqProtein = XP_001001311
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 58137019
    | Mm_GenLoc_end = 58137936
    | Mm_Uniprot = 
  }}
}}
'''Heterogeneous nuclear ribonucleoprotein A0''', also known as '''HNRPA0''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HNRPA0 heterogeneous nuclear ribonucleoprotein A0| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10949| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind RNAs, followed by a glycine-rich C-terminus.<ref name="entrez">{{cite web | title = Entrez Gene: HNRPA0 heterogeneous nuclear ribonucleoprotein A0| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10949| accessdate = }}</ref>
| summary_text = This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins ([[hnRNP]]s). The hnRNPs are [[RNA]] binding proteins and they complex with heterogeneous nuclear RNA ([[hnRNA]]). These proteins are associated with pre-[[mRNA]]s in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the [[Nucleus (cell)|nucleus]], some seem to shuttle between the nucleus and the [[cytoplasm]]. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-[[RNA recognition motif|RRM]] domains that bind RNAs, followed by a [[glycine]]-rich [[C-terminus]].<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317-20 |year= 1992 |pmid= 1602151 |doi= }}
*{{cite journal  |vauthors=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317–20 |year= 1992 |pmid= 1602151 |doi=10.1016/S0163-4453(05)80037-4 }}
*{{cite journal  | author=Myer VE, Steitz JA |title=Isolation and characterization of a novel, low abundance hnRNP protein: A0. |journal=RNA |volume=1 |issue= 2 |pages= 171-82 |year= 1995 |pmid= 7585247 |doi= }}
*{{cite journal  |vauthors=Cross SH, Charlton JA, Nan X, Bird AP |title=Purification of CpG islands using a methylated DNA binding column. |journal=Nat. Genet. |volume=6 |issue= 3 |pages= 236–44 |year= 1994 |pmid= 8012384 |doi= 10.1038/ng0394-236 }}
*{{cite journal  | author=Cross SH, Charlton JA, Nan X, Bird AP |title=Purification of CpG islands using a methylated DNA binding column. |journal=Nat. Genet. |volume=6 |issue= 3 |pages= 236-44 |year= 1994 |pmid= 8012384 |doi= 10.1038/ng0394-236 }}
*{{cite journal   |vauthors=Li SH, McInnis MG, Margolis RL, etal |title=Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms. |journal=Genomics |volume=16 |issue= 3 |pages= 572–9 |year= 1993 |pmid= 8325628 |doi= 10.1006/geno.1993.1232 }}
*{{cite journal | author=Li SH, McInnis MG, Margolis RL, ''et al.'' |title=Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms. |journal=Genomics |volume=16 |issue= 3 |pages= 572-9 |year= 1993 |pmid= 8325628 |doi= 10.1006/geno.1993.1232 }}
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal   |vauthors=Hillier LD, Lennon G, Becker M, etal |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807 }}
*{{cite journal | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi=  }}
*{{cite journal   |vauthors=Lai F, Godley LA, Joslin J, etal |title=Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q). |journal=Genomics |volume=71 |issue= 2 |pages= 235–45 |year= 2001 |pmid= 11161817 |doi= 10.1006/geno.2000.6414 }}
*{{cite journal | author=Lai F, Godley LA, Joslin J, ''et al.'' |title=Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q). |journal=Genomics |volume=71 |issue= 2 |pages= 235-45 |year= 2001 |pmid= 11161817 |doi= 10.1006/geno.2000.6414 }}
*{{cite journal   |vauthors=Rousseau S, Morrice N, Peggie M, etal |title=Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs. |journal=EMBO J. |volume=21 |issue= 23 |pages= 6505–14 |year= 2003 |pmid= 12456657 |doi=10.1093/emboj/cdf639  | pmc=136943 }}
*{{cite journal | author=Rousseau S, Morrice N, Peggie M, ''et al.'' |title=Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs. |journal=EMBO J. |volume=21 |issue= 23 |pages= 6505-14 |year= 2003 |pmid= 12456657 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Rush J, Moritz A, Lee KA, etal |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal   |vauthors=Andersen JS, Lam YW, Leung AK, etal |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal  |vauthors=Ong SE, Mittler G, Mann M |title=Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. |journal=Nat. Methods |volume=1 |issue= 2 |pages= 119–26 |year= 2005 |pmid= 15782174 |doi= 10.1038/nmeth715 }}
*{{cite journal  | author=Ong SE, Mittler G, Mann M |title=Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. |journal=Nat. Methods |volume=1 |issue= 2 |pages= 119-26 |year= 2005 |pmid= 15782174 |doi= 10.1038/nmeth715 }}
}}
}}
{{refend}}
{{refend}}


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{{Ribonucleoproteins}}
 
 
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Latest revision as of 13:57, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Heterogeneous nuclear ribonucleoprotein A0 is a protein that in humans is encoded by the HNRNPA0 gene.[1][2]

This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind RNAs, followed by a glycine-rich C-terminus.[2]

References

  1. ↑ Myer VE, Steitz JA (Dec 1995). "Isolation and characterization of a novel, low abundance hnRNP protein: A0". RNA. 1 (2): 171–82. PMC 1369071. PMID 7585247.
  2. ↑ 2.0 2.1 "Entrez Gene: HNRPA0 heterogeneous nuclear ribonucleoprotein A0".

Further reading



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