MAPK8IP3: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''C-jun-amino-terminal kinase-interacting protein 3''' is an [[enzyme]] that in humans is encoded by the ''MAPK8IP3'' [[gene]].<ref name="pmid10523642">{{cite journal |vauthors=Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto KI | title = JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway | journal = Mol Cell Biol | volume = 19 | issue = 11 | pages = 7539–48 |date=November 1999 | pmid = 10523642 | pmc = 84763 | doi = 10.1128/mcb.19.11.7539}}</ref><ref name="pmid10629060">{{cite journal |vauthors=Kelkar N, Gupta S, Dickens M, Davis RJ | title = Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3 | journal = Mol Cell Biol | volume = 20 | issue = 3 | pages = 1030–43 |date=February 2000 | pmid = 10629060 | pmc = 85220 | doi =10.1128/MCB.20.3.1030-1043.2000 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23162| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Mitogen-activated protein kinase 8 interacting protein 3
| HGNCid = 6884
| Symbol = MAPK8IP3
| AltSymbols =; DKFZp762N1113; FLJ00027; JIP3; JSAP1; KIAA1066; SYD2
| OMIM = 605431
| ECnumber =
| Homologene = 22790
| MGIid = 1353598
| GeneAtlas_image1 = PBB_GE_MAPK8IP3_213177_at_tn.png
| GeneAtlas_image2 = PBB_GE_MAPK8IP3_213178_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_MAPK8IP3_216139_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005078 |text = MAP-kinase scaffold activity}} {{GNF_GO|id=GO:0019894 |text = kinesin binding}} {{GNF_GO|id=GO:0019901 |text = protein kinase binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0016192 |text = vesicle-mediated transport}} {{GNF_GO|id=GO:0046328 |text = regulation of JNK cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23162
    | Hs_Ensembl = ENSG00000138834
    | Hs_RefseqProtein = NP_001035529
    | Hs_RefseqmRNA = NM_001040439
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 1696222
    | Hs_GenLoc_end = 1760318
    | Hs_Uniprot = Q9UPT6
    | Mm_EntrezGene = 30957
    | Mm_Ensembl = ENSMUSG00000024163
    | Mm_RefseqmRNA = NM_013931
    | Mm_RefseqProtein = NP_038959
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 24625134
    | Mm_GenLoc_end = 24664555
    | Mm_Uniprot = Q3UHB5
  }}
}}
'''Mitogen-activated protein kinase 8 interacting protein 3''', also known as '''MAPK8IP3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23162| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23162| accessdate = }}</ref>
| summary_text = The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.<ref name="entrez"/>
}}
}}
==Interactions==
MAPK8IP3 has been shown to [[Protein-protein interaction|interact]] with [[ASK1]],<ref name=pmid12189133>{{cite journal |last=Matsuura |first=Hiroshi |authorlink= |author2=Nishitoh Hideki |author3=Takeda Kohsuke |author4=Matsuzawa Atsushi |author5=Amagasa Teruo |author6=Ito Michihiko |author7=Yoshioka Katsuji |author8=Ichijo Hidenori  |date=October 2002  |title=Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade |journal=J. Biol. Chem. |volume=277 |issue=43 |pages=40703–9 |publisher= |location = United States| issn = 0021-9258| pmid = 12189133 |doi = 10.1074/jbc.M202004200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[C-Raf]],<ref name=pmid10523642 /><ref name=pmid11044439>{{cite journal |last=Kuboki |first=Y |authorlink= |author2=Ito M |author3=Takamatsu N |author4=Yamamoto K I |author5=Shiba T |author6=Yoshioka K  |date=December 2000  |title=A scaffold protein in the c-Jun  NH2-terminal kinase signaling pathways suppresses the extracellular signal-regulated kinase signaling pathways |journal=J. Biol. Chem. |volume=275 |issue=51 |pages=39815–8 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 11044439 |doi = 10.1074/jbc.C000403200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[PTK2]],<ref name=pmid12226752>{{cite journal |last=Takino |first=Takahisa |authorlink= |author2=Yoshioka Katsuji |author3=Miyamori Hisashi |author4=Yamada Kenneth M |author5=Sato Hiroshi  |date=September 2002  |title=A scaffold protein in the c-Jun  N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated |journal=Oncogene |volume=21 |issue=42 |pages=6488–97 |publisher= |location = England| issn = 0950-9232| pmid = 12226752 |doi = 10.1038/sj.onc.1205840 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[MAPK10]],<ref name=pmid10523642/><ref name=pmid10629060 /><ref name=pmid12189133/> [[Mitogen-activated protein kinase 9]],<ref name=pmid10523642/><ref name=pmid10629060/> [[MAPK8]],<ref name=pmid10523642/><ref name=pmid10629060/> [[MAP2K1]],<ref name=pmid10523642/><ref name=pmid11044439/> [[KLC2]],<ref name=pmid11106729>{{cite journal |doi=10.1016/S0092-8674(00)00162-8 |last=Bowman |first=A B |authorlink= |author2=Kamal A |author3=Ritchings B W |author4=Philp A V |author5=McGrail M |author6=Gindhart J G |author7=Goldstein L S  |date=November 2000  |title=Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein |journal=Cell |volume=103 |issue=4 |pages=583–94 |publisher= |location = UNITED STATES| issn = 0092-8674| pmid = 11106729 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[MAP2K7]],<ref name=pmid10629060/><ref name=pmid12189133/> [[KLC1]],<ref name=pmid11106729/> [[MAPK8IP2]]<ref name=pmid10629060/> and [[MAP2K4]].<ref name=pmid10523642/><ref name=pmid12189133/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Kikuno R, Nagase T, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197-205 |year= 1999 |pmid= 10470851 |doi=  }}
*{{cite journal   |vauthors=Kikuno R, Nagase T, Ishikawa K, etal |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197–205 |year= 1999 |pmid= 10470851 |doi=10.1093/dnares/6.3.197 }}
*{{cite journal | author=Ito M, Yoshioka K, Akechi M, ''et al.'' |title=JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway. |journal=Mol. Cell. Biol. |volume=19 |issue= 11 |pages= 7539-48 |year= 1999 |pmid= 10523642 |doi= }}
*{{cite journal   |vauthors=Kuboki Y, Ito M, Takamatsu N, etal |title=A scaffold protein in the c-Jun  NH2-terminal kinase signaling pathways suppresses the extracellular signal-regulated kinase signaling pathways. |journal=J. Biol. Chem. |volume=275 |issue= 51 |pages= 39815–8 |year= 2001 |pmid= 11044439 |doi= 10.1074/jbc.C000403200 }}
*{{cite journal | author=Kelkar N, Gupta S, Dickens M, Davis RJ |title=Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. |journal=Mol. Cell. Biol. |volume=20 |issue= 3 |pages= 1030-43 |year= 2000 |pmid= 10629060 |doi= }}
*{{cite journal   |vauthors=Bowman AB, Kamal A, Ritchings BW, etal |title=Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein. |journal=Cell |volume=103 |issue= 4 |pages= 583–94 |year= 2001 |pmid= 11106729 |doi=10.1016/S0092-8674(00)00162-8  }}
*{{cite journal | author=Kuboki Y, Ito M, Takamatsu N, ''et al.'' |title=A scaffold protein in the c-Jun NH2-terminal kinase signaling pathways suppresses the extracellular signal-regulated kinase signaling pathways. |journal=J. Biol. Chem. |volume=275 |issue= 51 |pages= 39815-8 |year= 2001 |pmid= 11044439 |doi= 10.1074/jbc.C000403200 }}
*{{cite journal   |vauthors=Daniels RJ, Peden JF, Lloyd C, etal |title=Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. |journal=Hum. Mol. Genet. |volume=10 |issue= 4 |pages= 339–52 |year= 2001 |pmid= 11157797 |doi=10.1093/hmg/10.4.339  }}
*{{cite journal | author=Bowman AB, Kamal A, Ritchings BW, ''et al.'' |title=Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein. |journal=Cell |volume=103 |issue= 4 |pages= 583-94 |year= 2001 |pmid= 11106729 |doi=  }}
*{{cite journal   |vauthors=Hattori A, Okumura K, Nagase T, etal |title=Characterization of long cDNA clones from human adult spleen. |journal=DNA Res. |volume=7 |issue= 6 |pages= 357–66 |year= 2001 |pmid= 11214971 |doi=10.1093/dnares/7.6.357 }}
*{{cite journal | author=Daniels RJ, Peden JF, Lloyd C, ''et al.'' |title=Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. |journal=Hum. Mol. Genet. |volume=10 |issue= 4 |pages= 339-52 |year= 2001 |pmid= 11157797 |doi= }}
*{{cite journal   |vauthors=Akechi M, Ito M, Uemura K, etal |title=Expression of JNK cascade scaffold protein JSAP1 in the mouse nervous system. |journal=Neurosci. Res. |volume=39 |issue= 4 |pages= 391–400 |year= 2001 |pmid= 11274738 |doi=10.1016/S0168-0102(01)00194-8  }}
*{{cite journal | author=Hattori A, Okumura K, Nagase T, ''et al.'' |title=Characterization of long cDNA clones from human adult spleen. |journal=DNA Res. |volume=7 |issue= 6 |pages= 357-66 |year= 2001 |pmid= 11214971 |doi=  }}
*{{cite journal   |vauthors=Byrd DT, Kawasaki M, Walcoff M, etal |title=UNC-16, a JNK-signaling scaffold protein, regulates vesicle transport in C. elegans. |journal=Neuron |volume=32 |issue= 5 |pages= 787–800 |year= 2002 |pmid= 11738026 |doi=10.1016/S0896-6273(01)00532-3 }}
*{{cite journal | author=Akechi M, Ito M, Uemura K, ''et al.'' |title=Expression of JNK cascade scaffold protein JSAP1 in the mouse nervous system. |journal=Neurosci. Res. |volume=39 |issue= 4 |pages= 391-400 |year= 2001 |pmid= 11274738 |doi= }}
*{{cite journal   |vauthors=Matsuura H, Nishitoh H, Takeda K, etal |title=Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40703–9 |year= 2002 |pmid= 12189133 |doi= 10.1074/jbc.M202004200 }}
*{{cite journal | author=Byrd DT, Kawasaki M, Walcoff M, ''et al.'' |title=UNC-16, a JNK-signaling scaffold protein, regulates vesicle transport in C. elegans. |journal=Neuron |volume=32 |issue= 5 |pages= 787-800 |year= 2002 |pmid= 11738026 |doi= }}
*{{cite journal   |vauthors=Takino T, Yoshioka K, Miyamori H, etal |title=A scaffold protein in the c-Jun  N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated. |journal=Oncogene |volume=21 |issue= 42 |pages= 6488–97 |year= 2002 |pmid= 12226752 |doi= 10.1038/sj.onc.1205840 }}
*{{cite journal | author=Matsuura H, Nishitoh H, Takeda K, ''et al.'' |title=Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40703-9 |year= 2002 |pmid= 12189133 |doi= 10.1074/jbc.M202004200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Takino T, Yoshioka K, Miyamori H, ''et al.'' |title=A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated. |journal=Oncogene |volume=21 |issue= 42 |pages= 6488-97 |year= 2002 |pmid= 12226752 |doi= 10.1038/sj.onc.1205840 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446 }}
*{{cite journal  | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal  |vauthors=Morita N, Iizuka K, Murakami T, Kawaguchi H |title=N-terminal kinase, and c-Src are activated in human aortic smooth muscle cells by pressure stress. |journal=Mol. Cell. Biochem. |volume=262 |issue= 1-2 |pages= 71–8 |year= 2005 |pmid= 15532711 |doi=10.1023/B:MCBI.0000038218.09259.1c  }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Martin J, Han C, Gordon LA, etal |title=The sequence and analysis of duplication-rich human chromosome 16. |journal=Nature |volume=432 |issue= 7020 |pages= 988–94 |year= 2005 |pmid= 15616553 |doi= 10.1038/nature03187 }}
*{{cite journal  | author=Morita N, Iizuka K, Murakami T, Kawaguchi H |title=N-terminal kinase, and c-Src are activated in human aortic smooth muscle cells by pressure stress. |journal=Mol. Cell. Biochem. |volume=262 |issue= 1-2 |pages= 71-8 |year= 2005 |pmid= 15532711 |doi= }}
*{{cite journal  |vauthors=Song JJ, Lee YJ |title=Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators. |journal=J. Biol. Chem. |volume=280 |issue= 29 |pages= 26845–55 |year= 2005 |pmid= 15911620 |doi= 10.1074/jbc.M502318200 }}
*{{cite journal | author=Martin J, Han C, Gordon LA, ''et al.'' |title=The sequence and analysis of duplication-rich human chromosome 16. |journal=Nature |volume=432 |issue= 7020 |pages= 988-94 |year= 2005 |pmid= 15616553 |doi= 10.1038/nature03187 }}
*{{cite journal   |vauthors=Takino T, Nakada M, Miyamori H, etal |title=JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration. |journal=J. Biol. Chem. |volume=280 |issue= 45 |pages= 37772–81 |year= 2006 |pmid= 16141199 |doi= 10.1074/jbc.M505241200 }}
*{{cite journal | author=Song JJ, Lee YJ |title=Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators. |journal=J. Biol. Chem. |volume=280 |issue= 29 |pages= 26845-55 |year= 2005 |pmid= 15911620 |doi= 10.1074/jbc.M502318200 }}
*{{cite journal   |vauthors=Oh JH, Yang JO, Hahn Y, etal |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 }}
*{{cite journal  | author=Takino T, Nakada M, Miyamori H, ''et al.'' |title=JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration. |journal=J. Biol. Chem. |volume=280 |issue= 45 |pages= 37772-81 |year= 2006 |pmid= 16141199 |doi= 10.1074/jbc.M505241200 }}
*{{cite journal | author=Oh JH, Yang JO, Hahn Y, ''et al.'' |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942-54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{WikiDoc Sources}}
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

Revision as of 06:08, 4 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

C-jun-amino-terminal kinase-interacting protein 3 is an enzyme that in humans is encoded by the MAPK8IP3 gene.[1][2][3]

The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[3]

Interactions

MAPK8IP3 has been shown to interact with ASK1,[4] C-Raf,[1][5] PTK2,[6] MAPK10,[1][2][4] Mitogen-activated protein kinase 9,[1][2] MAPK8,[1][2] MAP2K1,[1][5] KLC2,[7] MAP2K7,[2][4] KLC1,[7] MAPK8IP2[2] and MAP2K4.[1][4]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto KI (November 1999). "JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway". Mol Cell Biol. 19 (11): 7539–48. doi:10.1128/mcb.19.11.7539. PMC 84763. PMID 10523642.
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Kelkar N, Gupta S, Dickens M, Davis RJ (February 2000). "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3". Mol Cell Biol. 20 (3): 1030–43. doi:10.1128/MCB.20.3.1030-1043.2000. PMC 85220. PMID 10629060.
  3. ↑ 3.0 3.1 "Entrez Gene: MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3".
  4. ↑ 4.0 4.1 4.2 4.3 Matsuura, Hiroshi; Nishitoh Hideki; Takeda Kohsuke; Matsuzawa Atsushi; Amagasa Teruo; Ito Michihiko; Yoshioka Katsuji; Ichijo Hidenori (October 2002). "Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade". J. Biol. Chem. United States. 277 (43): 40703–9. doi:10.1074/jbc.M202004200. ISSN 0021-9258. PMID 12189133.
  5. ↑ 5.0 5.1 Kuboki, Y; Ito M; Takamatsu N; Yamamoto K I; Shiba T; Yoshioka K (December 2000). "A scaffold protein in the c-Jun NH2-terminal kinase signaling pathways suppresses the extracellular signal-regulated kinase signaling pathways". J. Biol. Chem. UNITED STATES. 275 (51): 39815–8. doi:10.1074/jbc.C000403200. ISSN 0021-9258. PMID 11044439.
  6. ↑ Takino, Takahisa; Yoshioka Katsuji; Miyamori Hisashi; Yamada Kenneth M; Sato Hiroshi (September 2002). "A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated". Oncogene. England. 21 (42): 6488–97. doi:10.1038/sj.onc.1205840. ISSN 0950-9232. PMID 12226752.
  7. ↑ 7.0 7.1 Bowman, A B; Kamal A; Ritchings B W; Philp A V; McGrail M; Gindhart J G; Goldstein L S (November 2000). "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. UNITED STATES. 103 (4): 583–94. doi:10.1016/S0092-8674(00)00162-8. ISSN 0092-8674. PMID 11106729.

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=MAPK8IP3&oldid=1417270"