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{{Infobox_gene}}
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'''Beta-1,3-N-acetylglucosaminyltransferase manic fringe''' is an [[enzyme]] that in humans is encoded by the ''MFNG'' [[gene]],<ref name="pmid9878264">{{cite journal |vauthors=Egan S, Herbrick JA, Tsui LC, Cohen B, Flock G, Beatty B, Scherer SW | title = Mapping of the human Lunatic Fringe (LFNG) gene to 7p22 and Manic Fringe (MFNG) to 22q12 | journal = Genomics | volume = 54 | issue = 3 | pages = 576–7 |date=Feb 1999 | pmid = 9878264 | pmc =  | doi = 10.1006/geno.1998.5559 }}</ref><ref name="pmid9187150">{{cite journal |vauthors=Johnston SH, Rauskolb C, Wilson R, Prabhakaran B, Irvine KD, Vogt TF | title = A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway | journal = Development | volume = 124 | issue = 11 | pages = 2245–54 |date=Jul 1997 | pmid = 9187150 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4242| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
| HGNCid = 7038
| Symbol = MFNG
| AltSymbols =;
| OMIM = 602577
| ECnumber =
| Homologene = 1803
| MGIid = 1095404
  | GeneAtlas_image1 = PBB_GE_MFNG_204153_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MFNG_204152_s_at_tn.png
| Function = {{GNF_GO|id=GO:0016757 |text = transferase activity, transferring glycosyl groups}}  
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007389 |text = pattern specification process}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4242
    | Hs_Ensembl = ENSG00000100060
    | Hs_RefseqProtein = NP_002396
    | Hs_RefseqmRNA = NM_002405
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 36195054
    | Hs_GenLoc_end = 36212385
    | Hs_Uniprot = O00587
    | Mm_EntrezGene = 17305
    | Mm_Ensembl = ENSMUSG00000018169
    | Mm_RefseqmRNA = XM_984857
    | Mm_RefseqProtein = XP_989951
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 78583137
    | Mm_GenLoc_end = 78600713
    | Mm_Uniprot = Q3UPI0
  }}
}}
'''MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase''', also known as '''MFNG''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4242| accessdate = }}</ref>
 
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| section_title =  
| section_title =  
| summary_text = This gene is a member of the fringe gene family which also includes Radical and Lunatic fringe. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta1,3 N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling.<ref name="entrez">{{cite web | title = Entrez Gene: MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4242| accessdate = }}</ref>
| summary_text = a member of the [[fringe gene]] family which also includes the ''radical fringe'' ([[RFNG]]) and ''lunatic fringe'' ([[LFNG]]).<ref>[http://www.nature.com/news/2006/061106/full/news061106-2.html "Troublesome gene names get the boot"], 6 November 2006, Michael Hopkin, nature.com</ref><ref>[https://psmag.com/sonic-hedgehog-dicer-and-the-problem-with-naming-genes-113c58df8f7a#.os08udsyk "Sonic Hedgehog, DICER, and the Problem With Naming Genes"], Sep 26, 2014, Michael White. psmag.com</ref>
 
They all encode evolutionarily conserved proteins that act in the [[Notch signaling pathway|Notch receptor pathway]] to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta1,3 N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Johnston SH, Rauskolb C, Wilson R, ''et al.'' |title=A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. |journal=Development |volume=124 |issue= 11 |pages= 2245-54 |year= 1997 |pmid= 9187150 |doi=  }}
*{{cite journal  | author=Cohen B |title=Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila |journal=Nat. Genet. |volume=16 |issue= 3 |pages= 283–8 |year= 1997 |pmid= 9207795 |doi= 10.1038/ng0797-283  |name-list-format=vanc| author2=Bashirullah A  | author3=Dagnino L  | display-authors=3  | last4=Campbell  | first4=Christine  | last5=Fisher  | first5=William W. | last6=Leow  | first6=Ching Ching  | last7=Whiting  | first7=Elisabeth  | last8=Ryan  | first8=David  | last9=Zinyk  | first9=Dawn }}
*{{cite journal  | author=Cohen B, Bashirullah A, Dagnino L, ''et al.'' |title=Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila. |journal=Nat. Genet. |volume=16 |issue= 3 |pages= 283-8 |year= 1997 |pmid= 9207795 |doi= 10.1038/ng0797-283 }}
*{{cite journal  | author=Moran JL |title=Genomic structure, mapping, and expression analysis of the mammalian Lunatic, Manic, and Radical fringe genes |journal=Mamm. Genome |volume=10 |issue= 6 |pages= 535–41 |year= 1999 |pmid= 10341080 |doi=10.1007/s003359901039  |name-list-format=vanc| author2=Johnston SH  | author3=Rauskolb C  | display-authors=3  | last4=Bhalerao  | first4=Jayant  | last5=Bowcock  | first5=Anne M.  | last6=Vogt  | first6=Thomas F. }}
*{{cite journal | author=Egan S, Herbrick JA, Tsui LC, ''et al.'' |title=Mapping of the human Lunatic Fringe (LFNG) gene to 7p22 and Manic Fringe (MFNG) to 22q12. |journal=Genomics |volume=54 |issue= 3 |pages= 576-7 |year= 1999 |pmid= 9878264 |doi= 10.1006/geno.1998.5559 }}
*{{cite journal  | author=Dunham I |title=The DNA sequence of human chromosome 22 |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 |name-list-format=vanc| author2=Shimizu N  | author3=Roe BA  | display-authors=3  | last4=Bruskiewich  | first4=R.  | last5=Beare  | first5=D. M.  | last6=Clamp  | first6=M.  | last7=Smink  | first7=L. J.  | last8=Ainscough  | first8=R.  | last9=Almeida  | first9=J. P. }}
*{{cite journal  | author=Moran JL, Johnston SH, Rauskolb C, ''et al.'' |title=Genomic structure, mapping, and expression analysis of the mammalian Lunatic, Manic, and Radical fringe genes. |journal=Mamm. Genome |volume=10 |issue= 6 |pages= 535-41 |year= 1999 |pmid= 10341080 |doi=  }}
*{{cite journal  |vauthors=Van Tine BA, Knops J, Shaw GM, May WA |title=Assignment of human MFNG, manic fringe Drosophila homolog, to 22q13.1 using tyramide fluorescence in situ hybridization (T-FISH) |journal=Cytogenet. Cell Genet. |volume=87 |issue= 1–2 |pages= 132–3 |year= 2000 |pmid= 10640833 |doi=10.1159/000015379 }}
*{{cite journal  | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal  | author=Moloney DJ |title=Fringe is a glycosyltransferase that modifies Notch |journal=Nature |volume=406 |issue= 6794 |pages= 369–75 |year= 2000 |pmid= 10935626 |doi= 10.1038/35019000 |name-list-format=vanc| author2=Panin VM  | author3=Johnston SH  | display-authors=3  | last4=Chen  | first4=Jihua  | last5=Shao  | first5=Li  | last6=Wilson  | first6=Richa  | last7=Wang  | first7=Yang  | last8=Stanley  | first8=Pamela  | last9=Irvine  | first9=Kenneth D. }}
*{{cite journal  | author=Van Tine BA, Knops J, Shaw GM, May WA |title=Assignment of human MFNG, manic fringe Drosophila homolog, to 22q13.1 using tyramide fluorescence in situ hybridization (T-FISH). |journal=Cytogenet. Cell Genet. |volume=87 |issue= 1-2 |pages= 132-3 |year= 2000 |pmid= 10640833 |doi=  }}
*{{cite journal  | author=Shimizu K |title=Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 25753–8 |year= 2001 |pmid= 11346656 |doi= 10.1074/jbc.M103473200 |name-list-format=vanc| author2=Chiba S  | author3=Saito T  | display-authors=3  | last4=Kumano  | first4=K  | last5=Takahashi  | first5=T  | last6=Hirai  | first6=H }}
*{{cite journal  | author=Moloney DJ, Panin VM, Johnston SH, ''et al.'' |title=Fringe is a glycosyltransferase that modifies Notch. |journal=Nature |volume=406 |issue= 6794 |pages= 369-75 |year= 2000 |pmid= 10935626 |doi= 10.1038/35019000 }}
*{{cite journal  |vauthors=Thélu J, Rossio P, Favier B |title=Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing |journal=BMC Dermatol. |volume=2|pages= 7 |year= 2003 |pmid= 11978185 |doi=10.1186/1471-5945-2-7  | pmc=111189 }}
*{{cite journal  | author=Shimizu K, Chiba S, Saito T, ''et al.'' |title=Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 25753-8 |year= 2001 |pmid= 11346656 |doi= 10.1074/jbc.M103473200 }}
*{{cite journal  | author=Panin VM |title=Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 29945–52 |year= 2002 |pmid= 12036964 |doi= 10.1074/jbc.M204445200 |name-list-format=vanc| author2=Shao L  | author3=Lei L  | display-authors=3  | last4=Moloney  | first4=DJ  | last5=Irvine  | first5=KD  | last6=Haltiwanger  | first6=RS }}
*{{cite journal  | author=Thélu J, Rossio P, Favier B |title=Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing. |journal=BMC Dermatol. |volume=2 |issue=  |pages= 7 |year= 2003 |pmid= 11978185 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Panin VM, Shao L, Lei L, ''et al.'' |title=Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe. |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 29945-52 |year= 2002 |pmid= 12036964 |doi= 10.1074/jbc.M204445200 }}
*{{cite journal  |vauthors=Shao L, Moloney DJ, Haltiwanger R |title=Fringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 7775–82 |year= 2003 |pmid= 12486116 |doi= 10.1074/jbc.M212221200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Veeraraghavalu K |title=Papillomavirus-Mediated Neoplastic Progression Is Associated with Reciprocal Changes in Jagged1 and Manic Fringe Expression Linked to Notch Activation |journal=J. Virol. |volume=78 |issue= 16 |pages= 8687–700 |year= 2004 |pmid= 15280477 |doi= 10.1128/JVI.78.16.8687-8700.2004 | pmc=479091  |name-list-format=vanc| author2=Pett M  | author3=Kumar RV  | display-authors=3  | last4=Nair  | first4=P.  | last5=Rangarajan  | first5=A.  | last6=Stanley  | first6=M. A.  | last7=Krishna  | first7=S. }}
*{{cite journal  | author=Shao L, Moloney DJ, Haltiwanger R |title=Fringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 7775-82 |year= 2003 |pmid= 12486116 |doi= 10.1074/jbc.M212221200 }}
*{{cite journal  | author=Collins JE |title=A genome annotation-driven approach to cloning the human ORFeome |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604  |name-list-format=vanc| author2=Wright CL  | author3=Edwards CA  | display-authors=3  | last4=Davis  | first4=Matthew P  | last5=Grinham  | first5=James A  | last6=Cole  | first6=Charlotte G  | last7=Goward  | first7=Melanie E  | last8=Aguado  | first8=Begoña  | last9=Mallya  | first9=Meera }}
*{{cite journal  | author=Veeraraghavalu K, Pett M, Kumar RV, ''et al.'' |title=Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation. |journal=J. Virol. |volume=78 |issue= 16 |pages= 8687-700 |year= 2004 |pmid= 15280477 |doi= 10.1128/JVI.78.16.8687-8700.2004 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}
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Latest revision as of 06:26, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Beta-1,3-N-acetylglucosaminyltransferase manic fringe is an enzyme that in humans is encoded by the MFNG gene,[1][2][3] a member of the fringe gene family which also includes the radical fringe (RFNG) and lunatic fringe (LFNG).[4][5]

They all encode evolutionarily conserved proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta1,3 N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling.[3]

References

  1. ↑ Egan S, Herbrick JA, Tsui LC, Cohen B, Flock G, Beatty B, Scherer SW (Feb 1999). "Mapping of the human Lunatic Fringe (LFNG) gene to 7p22 and Manic Fringe (MFNG) to 22q12". Genomics. 54 (3): 576–7. doi:10.1006/geno.1998.5559. PMID 9878264.
  2. ↑ Johnston SH, Rauskolb C, Wilson R, Prabhakaran B, Irvine KD, Vogt TF (Jul 1997). "A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway". Development. 124 (11): 2245–54. PMID 9187150.
  3. ↑ 3.0 3.1 "Entrez Gene: MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase".
  4. ↑ "Troublesome gene names get the boot", 6 November 2006, Michael Hopkin, nature.com
  5. ↑ "Sonic Hedgehog, DICER, and the Problem With Naming Genes", Sep 26, 2014, Michael White. psmag.com

Further reading



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