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{{Infobox_gene}}
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'''Olfactory receptor 51E2''' is a [[protein]] that in humans is encoded by the ''OR51E2'' [[gene]].<ref name="pmid11118034">{{cite journal | vauthors = Xu LL, Stackhouse BG, Florence K, Zhang W, Shanmugam N, Sesterhenn IA, Zou Z, Srikantan V, Augustus M, Roschke V, Carter K, McLeod DG, Moul JW, Soppett D, Srivastava S | title = PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer | journal = Cancer Res | volume = 60 | issue = 23 | pages = 6568–72 |date=Dec 2000 | pmid = 11118034 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: OR51E2 olfactory receptor, family 51, subfamily E, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81285| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Olfactory receptor, family 51, subfamily E, member 2
| HGNCid = 15195
| Symbol = OR51E2
| AltSymbols =; OR51E3P; OR52A2; PSGR
| OMIM = 
| ECnumber = 
| Homologene = 23713
| MGIid = 2157548
| GeneAtlas_image1 = PBB_GE_OR51E2_221424_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 81285
    | Hs_Ensembl = ENSG00000167332
    | Hs_RefseqProtein = NP_110401
    | Hs_RefseqmRNA = NM_030774
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 4657977
    | Hs_GenLoc_end = 4675648
    | Hs_Uniprot = Q9H255
    | Mm_EntrezGene = 170639
    | Mm_Ensembl = ENSMUSG00000043366
    | Mm_RefseqmRNA = NM_130866
    | Mm_RefseqProtein = NP_570936
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 102614552
    | Mm_GenLoc_end = 102633216
    | Mm_Uniprot =   
  }}
}}
'''Olfactory receptor, family 51, subfamily E, member 2''', also known as '''OR51E2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR51E2 olfactory receptor, family 51, subfamily E, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81285| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR51E2 olfactory receptor, family 51, subfamily E, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81285| accessdate = }}</ref>
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Adams MD, Kerlavage AR, Fleischmann RD, ''et al.'' |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3-174 |year= 1995 |pmid= 7566098 |doi= }}
*{{cite journal   |vauthors=Adams MD, Kerlavage AR, Fleischmann RD, etal |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3–174 |year= 1995 |pmid= 7566098 |doi=<!-- none available --> |url=http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf | format=PDF  }}
*{{cite journal  | author=Xu LL, Stackhouse BG, Florence K, ''et al.'' |title=PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer. |journal=Cancer Res. |volume=60 |issue= 23 |pages= 6568-72 |year= 2001 |pmid= 11118034 |doi=  }}
*{{cite journal   |vauthors=Xia C, Ma W, Wang F, etal |title=Identification of a prostate-specific G-protein coupled receptor in prostate cancer |journal=Oncogene |volume=20 |issue= 41 |pages= 5903–7 |year= 2001 |pmid= 11593396 |doi= 10.1038/sj.onc.1204803 }}
*{{cite journal | author=Xia C, Ma W, Wang F, ''et al.'' |title=Identification of a prostate-specific G-protein coupled receptor in prostate cancer. |journal=Oncogene |volume=20 |issue= 41 |pages= 5903-7 |year= 2001 |pmid= 11593396 |doi= 10.1038/sj.onc.1204803 }}
*{{cite journal   |vauthors=Yuan TT, Toy P, McClary JA, etal |title=Cloning and genetic characterization of an evolutionarily conserved human olfactory receptor that is differentially expressed across species |journal=Gene |volume=278 |issue= 1–2 |pages= 41–51 |year= 2002 |pmid= 11707321 |doi=10.1016/S0378-1119(01)00709-0 }}
*{{cite journal | author=Yuan TT, Toy P, McClary JA, ''et al.'' |title=Cloning and genetic characterization of an evolutionarily conserved human olfactory receptor that is differentially expressed across species. |journal=Gene |volume=278 |issue= 1-2 |pages= 41-51 |year= 2002 |pmid= 11707321 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584–9 |year= 2004 |pmid= 14983052 |doi=10.1073/pnas.0307882100  | pmc=356993 }}
*{{cite journal  | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Weng J, Wang J, Cai Y, etal |title=Increased expression of prostate-specific G-protein-coupled receptor in human prostate intraepithelial neoplasia and prostate cancers |journal=Int. J. Cancer |volume=113 |issue= 5 |pages= 811–8 |year= 2005 |pmid= 15499628 |doi= 10.1002/ijc.20635 }}
*{{cite journal | author=Weng J, Wang J, Cai Y, ''et al.'' |title=Increased expression of prostate-specific G-protein-coupled receptor in human prostate intraepithelial neoplasia and prostate cancers. |journal=Int. J. Cancer |volume=113 |issue= 5 |pages= 811-8 |year= 2005 |pmid= 15499628 |doi= 10.1002/ijc.20635 }}
*{{cite journal   |vauthors=Weng J, Ma W, Mitchell D, etal |title=Regulation of human prostate-specific G-protein coupled receptor, PSGR, by two distinct promoters and growth factors |journal=J. Cell. Biochem. |volume=96 |issue= 5 |pages= 1034–48 |year= 2006 |pmid= 16149059 |doi= 10.1002/jcb.20600 }}
*{{cite journal | author=Weng J, Ma W, Mitchell D, ''et al.'' |title=Regulation of human prostate-specific G-protein coupled receptor, PSGR, by two distinct promoters and growth factors. |journal=J. Cell. Biochem. |volume=96 |issue= 5 |pages= 1034-48 |year= 2006 |pmid= 16149059 |doi= 10.1002/jcb.20600 }}
*{{cite journal   |vauthors=Xu LL, Sun C, Petrovics G, etal |title=Quantitative expression profile of PSGR in prostate cancer |journal=Prostate Cancer Prostatic Dis. |volume=9 |issue= 1 |pages= 56–61 |year= 2006 |pmid= 16231015 |doi= 10.1038/sj.pcan.4500836 }}
*{{cite journal | author=Xu LL, Sun C, Petrovics G, ''et al.'' |title=Quantitative expression profile of PSGR in prostate cancer. |journal=Prostate Cancer Prostatic Dis. |volume=9 |issue= 1 |pages= 56-61 |year= 2006 |pmid= 16231015 |doi= 10.1038/sj.pcan.4500836 }}
*{{cite journal   |vauthors=Wang J, Weng J, Cai Y, etal |title=The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase |journal=Prostate |volume=66 |issue= 8 |pages= 847–57 |year= 2006 |pmid= 16491480 |doi= 10.1002/pros.20389 }}
*{{cite journal | author=Wang J, Weng J, Cai Y, ''et al.'' |title=The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase. |journal=Prostate |volume=66 |issue= 8 |pages= 847-57 |year= 2006 |pmid= 16491480 |doi= 10.1002/pros.20389 }}
}}
}}
{{refend}}
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{{NLM content}}
{{NLM content}}
{{membrane-protein-stub}}
 
{{Olfactory receptors}}
{{Olfactory receptors}}
[[Category:G protein coupled receptors]]
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Latest revision as of 00:31, 7 September 2017

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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

Olfactory receptor 51E2 is a protein that in humans is encoded by the OR51E2 gene.[1][2]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[2]

See also

References

  1. ↑ Xu LL, Stackhouse BG, Florence K, Zhang W, Shanmugam N, Sesterhenn IA, Zou Z, Srikantan V, Augustus M, Roschke V, Carter K, McLeod DG, Moul JW, Soppett D, Srivastava S (Dec 2000). "PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer". Cancer Res. 60 (23): 6568–72. PMID 11118034.
  2. ↑ 2.0 2.1 "Entrez Gene: OR51E2 olfactory receptor, family 51, subfamily E, member 2".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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