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{{about||company with same NASDAQ symbol|Palm,_Inc.|microscopy technique|Photoactivated localization microscopy}}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{Infobox_gene}}
{{GNF_Protein_box
'''Paralemmin''' is a [[protein]] that in humans is encoded by the ''PALM'' [[gene]].<ref name="pmid9615234">{{cite journal | vauthors = Burwinkel B, Miglierini G, Jenne DE, Gilbert DJ, Copeland NG, Jenkins NA, Ring HZ, Francke U, Kilimann MW | title = Structure of the human paralemmin gene (PALM), mapping to human chromosome 19p13.3 and mouse chromosome 10, and exclusion of coding mutations in grizzled, mocha, jittery, and hesitant mice | journal = Genomics | volume = 49 | issue = 3 | pages = 462–6 |date=Aug 1998 | pmid = 9615234 | pmc =  | doi = 10.1006/geno.1998.5276 }}</ref><ref name="pmid9813098">{{cite journal | vauthors = Kutzleb C, Sanders G, Yamamoto R, Wang X, Lichte B, Petrasch-Parwez E, Kilimann MW | title = Paralemmin, a Prenyl-Palmitoyl–anchored Phosphoprotein Abundant in Neurons and Implicated in Plasma Membrane Dynamics and Cell Process Formation | journal = J Cell Biol | volume = 143 | issue = 3 | pages = 795–813 |date=Dec 1998 | pmid = 9813098 | pmc = 2148134 | doi =10.1083/jcb.143.3.795 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PALM paralemmin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5064| accessdate = }}</ref>
| image =
| image_source =
| PDB =
| Name = Paralemmin
| HGNCid = 8594
| Symbol = PALM
| AltSymbols =; KIAA0270
| OMIM = 608134
| ECnumber =
| Homologene = 1937
| MGIid = 1261814
  | GeneAtlas_image1 = PBB_GE_PALM_203859_s_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016023 |text = cytoplasmic membrane-bound vesicle}}
| Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007010 |text = cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0008360 |text = regulation of cell shape}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5064
    | Hs_Ensembl = ENSG00000099864
    | Hs_RefseqProtein = NP_001035224
    | Hs_RefseqmRNA = NM_001040134
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 660002
    | Hs_GenLoc_end = 699328
    | Hs_Uniprot = O75781
    | Mm_EntrezGene = 18483
    | Mm_Ensembl = ENSMUSG00000035863
    | Mm_RefseqmRNA = NM_023128
    | Mm_RefseqProtein = NP_075617
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 79196845
    | Mm_GenLoc_end = 79224025
    | Mm_Uniprot = Q3UZP7
  }}
}}
'''Paralemmin''', also known as '''PALM''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PALM paralemmin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5064| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the paralemmin [[protein]] family. Other members of this family include [[BASP1|CAP-23]], [[Gap-43 protein|GAP-43]], [[MARCKS]], and [[MARCKSL1|MacMARCKS]]. The product of this gene is a [[prenylation|prenylated]] and [[palmitoylation|palmitoylated]] phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types.<ref name="pmid9615234" /><ref name="pmid9813098" /> Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.<ref name="entrez">{{cite web | title = Entrez Gene: PALM paralemmin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5064| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal | author=Nagase T, Seki N, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. |journal=DNA Res. |volume=3 |issue= 5 |pages= 321-9, 341-54 |year= 1997 |pmid= 9039502 |doi=  }}
*{{cite journal   |vauthors=Nagase T, Seki N, Ishikawa K, etal |title=Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain |journal=DNA Res. |volume=3 |issue= 5 |pages= 321–9, 341–54 |year= 1997 |pmid= 9039502 |doi=10.1093/dnares/3.5.321 }}
*{{cite journal  | author=Burwinkel B, Miglierini G, Jenne DE, ''et al.'' |title=Structure of the human paralemmin gene (PALM), mapping to human chromosome 19p13.3 and mouse chromosome 10, and exclusion of coding mutations in grizzled, mocha, jittery, and hesitant mice. |journal=Genomics |volume=49 |issue= 3 |pages= 462-6 |year= 1998 |pmid= 9615234 |doi= 10.1006/geno.1998.5276 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Kutzleb C, Sanders G, Yamamoto R, ''et al.'' |title=Paralemmin, a prenyl-palmitoyl-anchored phosphoprotein abundant in neurons and implicated in plasma membrane dynamics and cell process formation. |journal=J. Cell Biol. |volume=143 |issue= 3 |pages= 795-813 |year= 1998 |pmid= 9813098 |doi= }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Gauthier-Campbell C, Bredt DS, Murphy TH, ((El-Husseini Ael-D)) |title=Regulation of Dendritic Branching and Filopodia Formation in Hippocampal Neurons by Specific Acylated Protein Motifs |journal=Mol. Biol. Cell |volume=15 |issue= 5 |pages= 2205–17 |year= 2005 |pmid= 14978216 |doi= 10.1091/mbc.E03-07-0493 | pmc=404016 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Grimwood J, Gordon LA, Olsen A, etal |title=The DNA sequence and biology of human chromosome 19 |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal  | author=Gauthier-Campbell C, Bredt DS, Murphy TH, El-Husseini Ael-D |title=Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. |journal=Mol. Biol. Cell |volume=15 |issue= 5 |pages= 2205-17 |year= 2005 |pmid= 14978216 |doi= 10.1091/mbc.E03-07-0493 }}
*{{cite journal   |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal   |vauthors=Suzuki Y, Yamashita R, Shirota M, etal |title=Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 }}
*{{cite journal | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Basile M, Lin R, Kabbani N, etal |title=Paralemmin interacts with D3 dopamine receptors: implications for membrane localization and cAMP signaling |journal=Arch. Biochem. Biophys. |volume=446 |issue= 1 |pages= 60–8 |year= 2006 |pmid= 16386234 |doi= 10.1016/j.abb.2005.10.027 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Basile M, Lin R, Kabbani N, ''et al.'' |title=Paralemmin interacts with D3 dopamine receptors: implications for membrane localization and cAMP signaling. |journal=Arch. Biochem. Biophys. |volume=446 |issue= 1 |pages= 60-8 |year= 2006 |pmid= 16386234 |doi= 10.1016/j.abb.2005.10.027 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 17:31, 7 September 2017

For company with same NASDAQ symbol, see Palm,_Inc. For microscopy technique, see Photoactivated localization microscopy.
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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Paralemmin is a protein that in humans is encoded by the PALM gene.[1][2][3]

This gene encodes a member of the paralemmin protein family. Other members of this family include CAP-23, GAP-43, MARCKS, and MacMARCKS. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types.[1][2] Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.[3]

References

  1. ↑ 1.0 1.1 Burwinkel B, Miglierini G, Jenne DE, Gilbert DJ, Copeland NG, Jenkins NA, Ring HZ, Francke U, Kilimann MW (Aug 1998). "Structure of the human paralemmin gene (PALM), mapping to human chromosome 19p13.3 and mouse chromosome 10, and exclusion of coding mutations in grizzled, mocha, jittery, and hesitant mice". Genomics. 49 (3): 462–6. doi:10.1006/geno.1998.5276. PMID 9615234.
  2. ↑ 2.0 2.1 Kutzleb C, Sanders G, Yamamoto R, Wang X, Lichte B, Petrasch-Parwez E, Kilimann MW (Dec 1998). "Paralemmin, a Prenyl-Palmitoyl–anchored Phosphoprotein Abundant in Neurons and Implicated in Plasma Membrane Dynamics and Cell Process Formation". J Cell Biol. 143 (3): 795–813. doi:10.1083/jcb.143.3.795. PMC 2148134. PMID 9813098.
  3. ↑ 3.0 3.1 "Entrez Gene: PALM paralemmin".

Further reading



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