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{{ | '''Phosphatidylinositol-5-phosphate 4-kinase type-2 beta''' is an [[enzyme]] that in humans is encoded by the ''PIP4K2B'' [[gene]].<ref name="pmid9038203">{{cite journal | vauthors = Castellino AM, Parker GJ, Boronenkov IV, Anderson RA, Chao MV | title = A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase | journal = J Biol Chem | volume = 272 | issue = 9 | pages = 5861–70 |date=Apr 1997 | pmid = 9038203 | pmc = | doi =10.1074/jbc.272.9.5861 }}</ref><ref name="pmid14691457">{{cite journal | vauthors = Luoh SW, Venkatesan N, Tripathi R | title = Overexpression of the amplified Pip4k2beta gene from 17q11-12 in breast cancer cells confers proliferation advantage | journal = Oncogene | volume = 23 | issue = 7 | pages = 1354–63 |date=Feb 2004 | pmid = 14691457 | pmc = | doi = 10.1038/sj.onc.1207251 }}</ref><ref name="pmid9367159">{{cite journal | vauthors = Rameh LE, Tolias KF, Duckworth BC, Cantley LC | title = A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate | journal = Nature | volume = 390 | issue = 6656 | pages = 192–6 |date=Nov 1997 | pmid = 9367159 | pmc = | doi = 10.1038/36621 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PIP5K2B phosphatidylinositol-4-phosphate 5-kinase, type II, beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8396| accessdate = }}</ref> | ||
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| summary_text = The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate. This gene is a member of the phosphatidylinositol-4-phosphate 5-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor.<ref name="entrez">{{cite web | title = Entrez Gene: PIP5K2B phosphatidylinositol-4-phosphate 5-kinase, type II, beta| url = | | summary_text = The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate. This gene is a member of the phosphatidylinositol-4-phosphate 5-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor.<ref name="entrez">{{cite web | title = Entrez Gene: PIP5K2B phosphatidylinositol-4-phosphate 5-kinase, type II, beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8396| accessdate = }}</ref> | ||
}} | }} | ||
==Interactions== | |||
PIP4K2B has been shown to [[Protein-protein interaction|interact]] with [[TNFRSF1A]].<ref name=pmid9038203 /> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Niiro H, Clark EA |title=Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1. |journal=Immunity |volume=19 |issue= 5 |pages= 637–40 |year= 2003 |pmid= 14614850 |doi=10.1016/S1074-7613(03)00303-0 }} | ||
*{{cite journal | author=Carpenter CL |title=Btk-dependent regulation of phosphoinositide synthesis. |journal=Biochem. Soc. Trans. |volume=32 |issue= Pt 2 |pages= | *{{cite journal | author=Carpenter CL |title=Btk-dependent regulation of phosphoinositide synthesis. |journal=Biochem. Soc. Trans. |volume=32 |issue= Pt 2 |pages= 326–9 |year= 2004 |pmid= 15046600 |doi=10.1042/BST0320326 }} | ||
*{{cite journal |vauthors=Rao VD, Misra S, Boronenkov IV, etal |title=Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation. |journal=Cell |volume=94 |issue= 6 |pages= 829–39 |year= 1998 |pmid= 9753329 |doi=10.1016/S0092-8674(00)81741-9 }} | |||
*{{cite journal | *{{cite journal | vauthors=Boronenkov IV, Loijens JC, Umeda M, Anderson RA |title=Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors. |journal=Mol. Biol. Cell |volume=9 |issue= 12 |pages= 3547–60 |year= 1999 |pmid= 9843587 |doi= 10.1091/mbc.9.12.3547| pmc=25675 }} | ||
*{{cite journal |vauthors=Kutsenko AS, Gizatullin RZ, Al-Amin AN, etal |title=NotI flanking sequences: a tool for gene discovery and verification of the human genome. |journal=Nucleic Acids Res. |volume=30 |issue= 14 |pages= 3163–70 |year= 2002 |pmid= 12136098 |doi=10.1093/nar/gkf428 | pmc=135748 }} | |||
*{{cite journal | | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal | *{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }} | ||
*{{cite journal |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }} | |||
*{{cite journal | *{{cite journal |vauthors=Richardson JP, Wang M, Clarke JH, etal |title=Genomic tagging of endogenous type IIbeta phosphatidylinositol 5-phosphate 4-kinase in DT40 cells reveals a nuclear localisation. |journal=Cell. Signal. |volume=19 |issue= 6 |pages= 1309–14 |year= 2007 |pmid= 17303380 |doi= 10.1016/j.cellsig.2007.01.010 | pmc=1868964 }} | ||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=8396}} | |||
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Revision as of 16:11, 18 November 2017
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Phosphatidylinositol-5-phosphate 4-kinase type-2 beta is an enzyme that in humans is encoded by the PIP4K2B gene.[1][2][3][4]
The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate. This gene is a member of the phosphatidylinositol-4-phosphate 5-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor.[4]
Interactions
PIP4K2B has been shown to interact with TNFRSF1A.[1]
References
- ↑ 1.0 1.1 Castellino AM, Parker GJ, Boronenkov IV, Anderson RA, Chao MV (Apr 1997). "A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase". J Biol Chem. 272 (9): 5861–70. doi:10.1074/jbc.272.9.5861. PMID 9038203.
- ↑ Luoh SW, Venkatesan N, Tripathi R (Feb 2004). "Overexpression of the amplified Pip4k2beta gene from 17q11-12 in breast cancer cells confers proliferation advantage". Oncogene. 23 (7): 1354–63. doi:10.1038/sj.onc.1207251. PMID 14691457.
- ↑ Rameh LE, Tolias KF, Duckworth BC, Cantley LC (Nov 1997). "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". Nature. 390 (6656): 192–6. doi:10.1038/36621. PMID 9367159.
- ↑ 4.0 4.1 "Entrez Gene: PIP5K2B phosphatidylinositol-4-phosphate 5-kinase, type II, beta".
Further reading
- Niiro H, Clark EA (2003). "Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1". Immunity. 19 (5): 637–40. doi:10.1016/S1074-7613(03)00303-0. PMID 14614850.
- Carpenter CL (2004). "Btk-dependent regulation of phosphoinositide synthesis". Biochem. Soc. Trans. 32 (Pt 2): 326–9. doi:10.1042/BST0320326. PMID 15046600.
- Rao VD, Misra S, Boronenkov IV, et al. (1998). "Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation". Cell. 94 (6): 829–39. doi:10.1016/S0092-8674(00)81741-9. PMID 9753329.
- Boronenkov IV, Loijens JC, Umeda M, Anderson RA (1999). "Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors". Mol. Biol. Cell. 9 (12): 3547–60. doi:10.1091/mbc.9.12.3547. PMC 25675. PMID 9843587.
- Kutsenko AS, Gizatullin RZ, Al-Amin AN, et al. (2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Res. 30 (14): 3163–70. doi:10.1093/nar/gkf428. PMC 135748. PMID 12136098.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Richardson JP, Wang M, Clarke JH, et al. (2007). "Genomic tagging of endogenous type IIbeta phosphatidylinositol 5-phosphate 4-kinase in DT40 cells reveals a nuclear localisation". Cell. Signal. 19 (6): 1309–14. doi:10.1016/j.cellsig.2007.01.010. PMC 1868964. PMID 17303380.
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