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{{Infobox_gene}}
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'''1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1''' is an [[enzyme]] that in humans is encoded by the ''PLCD1'' [[gene]].<ref name="pmid9345909">{{cite journal |vauthors=Ishikawa S, Takahashi T, Ogawa M, Nakamura Y | title = Genomic structure of the human PLCD1 (phospholipase C delta 1) locus on 3p22→p21.3 | journal = Cytogenet Cell Genet | volume = 78 | issue = 1 | pages = 58–60 |date=Nov 1997 | pmid = 9345909 | pmc = | doi =10.1159/000134629  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PLCD1 phospholipase C, delta 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5333| accessdate = }}</ref>
| update_page = yes
PLCd1 is essential to maintain homeostasis of the skin.
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| update_citations = yes
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==See also==
{{GNF_Protein_box
[[Phospholipase C]]
| image = PBB_Protein_PLCD1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1djg.
| PDB = {{PDB2|1djg}}, {{PDB2|1djh}}, {{PDB2|1dji}}, {{PDB2|1djw}}, {{PDB2|1djx}}, {{PDB2|1djy}}, {{PDB2|1djz}}, {{PDB2|1mai}}, {{PDB2|1qas}}, {{PDB2|1qat}}, {{PDB2|2isd}}
| Name = Phospholipase C, delta 1
| HGNCid = 9060
| Symbol = PLCD1
| AltSymbols =;
| OMIM = 602142
| ECnumber = 
| Homologene = 21252
| MGIid = 97614
| GeneAtlas_image1 = PBB_GE_PLCD1_205125_at_tn.png
| Function = {{GNF_GO|id=GO:0004435 |text = phosphoinositide phospholipase C activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006644 |text = phospholipid metabolic process}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0016042 |text = lipid catabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5333
    | Hs_Ensembl = ENSG00000187091
    | Hs_RefseqProtein = NP_006216
    | Hs_RefseqmRNA = NM_006225
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 38023993
    | Hs_GenLoc_end = 38046137
    | Hs_Uniprot = P51178
    | Mm_EntrezGene = 18799
    | Mm_Ensembl = ENSMUSG00000010660
    | Mm_RefseqmRNA = NM_019676
    | Mm_RefseqProtein = NP_062650
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 118920228
    | Mm_GenLoc_end = 118942200
    | Mm_Uniprot = Q05DG3
  }}
}}
'''Phospholipase C, delta 1''', also known as '''PLCD1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PLCD1 phospholipase C, delta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5333| accessdate = }}</ref>


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==References==
{{PBB_Summary
{{reflist}}
| section_title =
| summary_text =
}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | author=Yagisawa H |title=Nucleocytoplasmic shuttling of phospholipase C-delta1: a link to Ca2+. |journal=J. Cell. Biochem. |volume=97 |issue= 2 |pages= 233–43 |year= 2006 |pmid= 16240320 |doi= 10.1002/jcb.20677 }}
| citations =
*{{cite journal   |vauthors=Cefai D, Debre P, Kaczorek M, etal |title=Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway. |journal=J. Clin. Invest. |volume=86 |issue= 6 |pages= 2117–24 |year= 1991 |pmid= 1979339 |doi=10.1172/JCI114950  | pmc=329852 }}
*{{cite journal  | author=Yagisawa H |title=Nucleocytoplasmic shuttling of phospholipase C-delta1: a link to Ca2+. |journal=J. Cell. Biochem. |volume=97 |issue= 2 |pages= 233-43 |year= 2006 |pmid= 16240320 |doi= 10.1002/jcb.20677 }}
*{{cite journal   |vauthors=Zauli G, Previati M, Caramelli E, etal |title=Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line. |journal=Eur. J. Immunol. |volume=25 |issue= 9 |pages= 2695–700 |year= 1995 |pmid= 7589147 |doi=10.1002/eji.1830250944 }}
*{{cite journal | author=Cefai D, Debre P, Kaczorek M, ''et al.'' |title=Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway. |journal=J. Clin. Invest. |volume=86 |issue= 6 |pages= 2117-24 |year= 1991 |pmid= 1979339 |doi=  }}
*{{cite journal   |vauthors=Cheng HF, Jiang MJ, Chen CL, etal |title=Cloning and identification of amino acid residues of human phospholipase C delta 1 essential for catalysis. |journal=J. Biol. Chem. |volume=270 |issue= 10 |pages= 5495–505 |year= 1995 |pmid= 7890667 |doi=10.1074/jbc.270.10.5495 }}
*{{cite journal | author=Zauli G, Previati M, Caramelli E, ''et al.'' |title=Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line. |journal=Eur. J. Immunol. |volume=25 |issue= 9 |pages= 2695-700 |year= 1995 |pmid= 7589147 |doi=  }}
*{{cite journal  |vauthors=Ghosh S, Pawelczyk T, Lowenstein JM |title=Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties. |journal=Protein Expr. Purif. |volume=9 |issue= 2 |pages= 262–78 |year= 1997 |pmid= 9056492 |doi=10.1006/prep.1996.0682  }}
*{{cite journal | author=Cheng HF, Jiang MJ, Chen CL, ''et al.'' |title=Cloning and identification of amino acid residues of human phospholipase C delta 1 essential for catalysis. |journal=J. Biol. Chem. |volume=270 |issue= 10 |pages= 5495-505 |year= 1995 |pmid= 7890667 |doi=  }}
*{{cite journal  |vauthors=Chen P, Mayne M, Power C, Nath A |title=The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22385–8 |year= 1997 |pmid= 9278385 |doi=10.1074/jbc.272.36.22385 }}
*{{cite journal  | author=Ghosh S, Pawelczyk T, Lowenstein JM |title=Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties. |journal=Protein Expr. Purif. |volume=9 |issue= 2 |pages= 262-78 |year= 1997 |pmid= 9056492 |doi= }}
*{{cite journal   |vauthors=Park ES, Won JH, Han KJ, etal |title=Phospholipase C-delta1 and oxytocin receptor signalling: evidence of its role as an effector. |journal=Biochem. J. |volume=331 |issue= 1|pages= 283–9 |year= 1998 |pmid= 9512491 |doi= | pmc=1219350 }}
*{{cite journal  | author=Chen P, Mayne M, Power C, Nath A |title=The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22385-8 |year= 1997 |pmid= 9278385 |doi=  }}
*{{cite journal   |vauthors=Shimohama S, Kamiya S, Fujii M, etal |title=Mutation in the pleckstrin homology domain of the human phospholipase C-delta 1 gene is associated with loss of function. |journal=Biochem. Biophys. Res. Commun. |volume=245 |issue= 3 |pages= 722–8 |year= 1998 |pmid= 9588182 |doi= 10.1006/bbrc.1998.8307 }}
*{{cite journal | author=Ishikawa S, Takahashi T, Ogawa M, Nakamura Y |title=Genomic structure of the human PLCD1 (phospholipase C delta 1) locus on 3p22-->p21.3. |journal=Cytogenet. Cell Genet. |volume=78 |issue= 1 |pages= 58-60 |year= 1997 |pmid= 9345909 |doi=  }}
*{{cite journal   |vauthors=Mayne M, Bratanich AC, Chen P, etal |title=HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease. |journal=Neuroimmunomodulation |volume=5 |issue= 3-4 |pages= 184–92 |year= 1998 |pmid= 9730685 |doi=10.1159/000026336  }}
*{{cite journal | author=Park ES, Won JH, Han KJ, ''et al.'' |title=Phospholipase C-delta1 and oxytocin receptor signalling: evidence of its role as an effector. |journal=Biochem. J. |volume=331 ( Pt 1) |issue= |pages= 283-9 |year= 1998 |pmid= 9512491 |doi= }}
*{{cite journal  |vauthors=Haughey NJ, Holden CP, Nath A, Geiger JD |title=Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat. |journal=J. Neurochem. |volume=73 |issue= 4 |pages= 1363–74 |year= 1999 |pmid= 10501179 |doi=10.1046/j.1471-4159.1999.0731363.x }}
*{{cite journal | author=Shimohama S, Kamiya S, Fujii M, ''et al.'' |title=Mutation in the pleckstrin homology domain of the human phospholipase C-delta 1 gene is associated with loss of function. |journal=Biochem. Biophys. Res. Commun. |volume=245 |issue= 3 |pages= 722-8 |year= 1998 |pmid= 9588182 |doi= 10.1006/bbrc.1998.8307 }}
*{{cite journal  |vauthors=Mayne M, Holden CP, Nath A, Geiger JD |title=Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages. |journal=J. Immunol. |volume=164 |issue= 12 |pages= 6538–42 |year= 2000 |pmid= 10843712 |doi=  10.4049/jimmunol.164.12.6538}}
*{{cite journal  | author=Mayne M, Bratanich AC, Chen P, ''et al.'' |title=HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease. |journal=Neuroimmunomodulation |volume=5 |issue= 3-4 |pages= 184-92 |year= 1998 |pmid= 9730685 |doi=  }}
*{{cite journal   |vauthors=Nash MS, Young KW, Willars GB, etal |title=Single-cell imaging of graded Ins(1,4,5)P3 production following G-protein-coupled-receptor activation. |journal=Biochem. J. |volume=356 |issue= Pt 1 |pages= 137–42 |year= 2001 |pmid= 11336645 |doi=10.1042/0264-6021:3560137  | pmc=1221821 }}
*{{cite journal  | author=Haughey NJ, Holden CP, Nath A, Geiger JD |title=Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat. |journal=J. Neurochem. |volume=73 |issue= 4 |pages= 1363-74 |year= 1999 |pmid= 10501179 |doi=  }}
*{{cite journal   |vauthors=Ananthanarayanan B, Das S, Rhee SG, etal |title=Membrane targeting of C2 domains of phospholipase C-delta isoforms. |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3568–75 |year= 2002 |pmid= 11706040 |doi= 10.1074/jbc.M109705200 }}
*{{cite journal | author=Mayne M, Holden CP, Nath A, Geiger JD |title=Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages. |journal=J. Immunol. |volume=164 |issue= 12 |pages= 6538-42 |year= 2000 |pmid= 10843712 |doi=  }}
*{{cite journal  |vauthors=Keshamouni VG, Mattingly RR, Reddy KB |title=Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells. A role for HER2 AND PKC-delta. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22558–65 |year= 2002 |pmid= 11960991 |doi= 10.1074/jbc.M202351200 }}
*{{cite journal | author=Nash MS, Young KW, Willars GB, ''et al.'' |title=Single-cell imaging of graded Ins(1,4,5)P3 production following G-protein-coupled-receptor activation. |journal=Biochem. J. |volume=356 |issue= Pt 1 |pages= 137-42 |year= 2001 |pmid= 11336645 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author=Ananthanarayanan B, Das S, Rhee SG, ''et al.'' |title=Membrane targeting of C2 domains of phospholipase C-delta isoforms. |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3568-75 |year= 2002 |pmid= 11706040 |doi= 10.1074/jbc.M109705200 }}
*{{cite journal  |vauthors=Bennasser Y, Badou A, Tkaczuk J, Bahraoui E |title=Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha. |journal=Virology |volume=303 |issue= 1 |pages= 174–80 |year= 2003 |pmid= 12482669 |doi=10.1006/viro.2002.1676  }}
*{{cite journal | author=Keshamouni VG, Mattingly RR, Reddy KB |title=Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells. A role for HER2 AND PKC-delta. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22558-65 |year= 2002 |pmid= 11960991 |doi= 10.1074/jbc.M202351200 }}
*{{cite journal  |vauthors=Guo Y, Philip F, Scarlata S |title=The Pleckstrin homology domains of phospholipases C-beta and -delta confer activation through a common site. |journal=J. Biol. Chem. |volume=278 |issue= 32 |pages= 29995–30004 |year= 2003 |pmid= 12761218 |doi= 10.1074/jbc.M301438200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Caprini M, Gomis A, Cabedo H, etal |title=GAP43 stimulates inositol trisphosphate-mediated calcium release in response to hypotonicity. |journal=EMBO J. |volume=22 |issue= 12 |pages= 3004–14 |year= 2003 |pmid= 12805215 |doi= 10.1093/emboj/cdg294  | pmc=162146 }}
*{{cite journal  | author=Bennasser Y, Badou A, Tkaczuk J, Bahraoui E |title=Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha. |journal=Virology |volume=303 |issue= 1 |pages= 174-80 |year= 2003 |pmid= 12482669 |doi= }}
*{{cite journal   |vauthors=Kim JY, Kim H, Lee SG, etal |title=Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site. |journal=Biochem. Biophys. Res. Commun. |volume=310 |issue= 3 |pages= 904–9 |year= 2003 |pmid= 14550290 |doi=10.1016/j.bbrc.2003.09.100 }}
*{{cite journal | author=Guo Y, Philip F, Scarlata S |title=The Pleckstrin homology domains of phospholipases C-beta and -delta confer activation through a common site. |journal=J. Biol. Chem. |volume=278 |issue= 32 |pages= 29995-30004 |year= 2003 |pmid= 12761218 |doi= 10.1074/jbc.M301438200 }}
*{{cite journal | author=Caprini M, Gomis A, Cabedo H, ''et al.'' |title=GAP43 stimulates inositol trisphosphate-mediated calcium release in response to hypotonicity. |journal=EMBO J. |volume=22 |issue= 12 |pages= 3004-14 |year= 2003 |pmid= 12805215 |doi= 10.1093/emboj/cdg294 }}
*{{cite journal  | author=Kim JY, Kim H, Lee SG, ''et al.'' |title=Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site. |journal=Biochem. Biophys. Res. Commun. |volume=310 |issue= 3 |pages= 904-9 |year= 2003 |pmid= 14550290 |doi= }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* [http://www.wikigenes.org/e/gene/e/24655.html WikiGenes entry for PLCD1]
 
{{PDB Gallery|geneid=5333}}
{{Esterases}}
{{Enzymes}}
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[[Category:EC 3.1.4]]
[[Category:EF-hand-containing proteins]]
 
 
{{gene-3-stub}}

Latest revision as of 18:16, 7 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1 is an enzyme that in humans is encoded by the PLCD1 gene.[1][2] PLCd1 is essential to maintain homeostasis of the skin.

See also

Phospholipase C

References

  1. ↑ Ishikawa S, Takahashi T, Ogawa M, Nakamura Y (Nov 1997). "Genomic structure of the human PLCD1 (phospholipase C delta 1) locus on 3p22→p21.3". Cytogenet Cell Genet. 78 (1): 58–60. doi:10.1159/000134629. PMID 9345909.
  2. ↑ "Entrez Gene: PLCD1 phospholipase C, delta 1".

Further reading

External links


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