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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1''' is an [[enzyme]] that in humans is encoded by the ''PLCE1'' [[gene]].<ref name="pmid11022047">{{cite journal | vauthors = Lopez I, Mak EC, Ding J, Hamm HE, Lomasney JW | title = A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway | journal = J Biol Chem | volume = 276 | issue = 4 | pages = 2758–65 | date = May 2001 | pmid = 11022047 | pmc =  | doi = 10.1074/jbc.M008119200 }}</ref><ref name="pmid11022048">{{cite journal | vauthors = Song C, Hu CD, Masago M, Kariyai K, Yamawaki-Kataoka Y, Shibatohge M, Wu D, Satoh T, Kataoka T | title = Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras | journal = J Biol Chem | volume = 276 | issue = 4 | pages = 2752–7 | date = May 2001 | pmid = 11022048 | pmc = | doi = 10.1074/jbc.M008324200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PLCE1 phospholipase C, epsilon 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51196| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_PLCE1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2bye.
| PDB = {{PDB2|2bye}}, {{PDB2|2byf}}, {{PDB2|2c5l}}
| Name = Phospholipase C, epsilon 1
| HGNCid = 17175
| Symbol = PLCE1
| AltSymbols =; PLCE; FLJ23659; KIAA1516; NPHS3
| OMIM = 608414
| ECnumber = 
| Homologene = 9478
| MGIid = 1921305
| GeneAtlas_image1 = PBB_GE_PLCE1_205111_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PLCE1_205112_at_tn.png
| Function = {{GNF_GO|id=GO:0004435 |text = phosphoinositide phospholipase C activity}} {{GNF_GO|id=GO:0005057 |text = receptor signaling protein activity}} {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0017016 |text = Ras GTPase binding}} {{GNF_GO|id=GO:0019899 |text = enzyme binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0000187 |text = activation of MAPK activity}} {{GNF_GO|id=GO:0001558 |text = regulation of cell growth}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006644 |text = phospholipid metabolic process}} {{GNF_GO|id=GO:0006651 |text = diacylglycerol biosynthetic process}} {{GNF_GO|id=GO:0006940 |text = regulation of smooth muscle contraction}} {{GNF_GO|id=GO:0007010 |text = cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0007173 |text = epidermal growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}} {{GNF_GO|id=GO:0007205 |text = protein kinase C activation}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0008277 |text = regulation of G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0016042 |text = lipid catabolic process}} {{GNF_GO|id=GO:0019722 |text = calcium-mediated signaling}} {{GNF_GO|id=GO:0045859 |text = regulation of protein kinase activity}} {{GNF_GO|id=GO:0046578 |text = regulation of Ras protein signal transduction}} {{GNF_GO|id=GO:0048016 |text = inositol phosphate-mediated signaling}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51196
    | Hs_Ensembl = ENSG00000138193
    | Hs_RefseqProtein = NP_057425
    | Hs_RefseqmRNA = NM_016341
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 95743736
    | Hs_GenLoc_end = 96078136
    | Hs_Uniprot = Q9P212
    | Mm_EntrezGene = 74055
    | Mm_Ensembl = ENSMUSG00000024998
    | Mm_RefseqmRNA = NM_019588
    | Mm_RefseqProtein = NP_062534
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 38589341
    | Mm_GenLoc_end = 38848017
    | Mm_Uniprot = Q8K4S1
  }}
}}
'''Phospholipase C, epsilon 1''', also known as '''PLCE1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PLCE1 phospholipase C, epsilon 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51196| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
PLCE1 belongs to the [[phospholipase]] family that catalyzes the hydrolysis of polyphosphoinositides such as [[phosphatidylinositol-4,5-bisphosphate]] (PtdIns(4,5)P2) to generate the second messengers [[Inositol-trisphosphate 3-kinase|Ins(1,4,5)P3 and diacylglycerol]]. These products initiate a cascade of intracellular responses that result in cell growth and differentiation and [[gene expression]].[supplied by OMIM]<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = PLCE1 belongs to the phospholipase family that catalyzes the hydrolysis of polyphosphoinositides such as phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) to generate the second messengers Ins(1,4,5)P3 and diacylglycerol. These products initiate a cascade of intracellular responses that result in cell growth and differentiation and gene expression.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: PLCE1 phospholipase C, epsilon 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51196| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Jefferson JA, Shankland SJ | title = Familial nephrotic syndrome: PLCE1 enters the fray. | journal = Nephrol. Dial. Transplant. | volume = 22 | issue = 7 | pages = 1849–52 | year = 2007 | pmid = 17449496 | doi = 10.1093/ndt/gfm098 }}
| citations =
* {{cite journal | vauthors = Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G | title = Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway. | journal = J. Clin. Invest. | volume = 86 | issue = 6 | pages = 2117–24 | year = 1991 | pmid = 1979339 | pmc = 329852 | doi = 10.1172/JCI114950 }}
*{{cite journal | author=Jefferson JA, Shankland SJ |title=Familial nephrotic syndrome: PLCE1 enters the fray. |journal=Nephrol. Dial. Transplant. |volume=22 |issue= 7 |pages= 1849-52 |year= 2007 |pmid= 17449496 |doi= 10.1093/ndt/gfm098 }}
* {{cite journal | vauthors = Zauli G, Previati M, Caramelli E, Bassini A, Falcieri E, Gibellini D, Bertolaso L, Bosco D, Robuffo I, Capitani S | title = Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line. | journal = Eur. J. Immunol. | volume = 25 | issue = 9 | pages = 2695–700 | year = 1995 | pmid = 7589147 | doi = 10.1002/eji.1830250944 }}
*{{cite journal | author=Cefai D, Debre P, Kaczorek M, ''et al.'' |title=Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway. |journal=J. Clin. Invest. |volume=86 |issue= 6 |pages= 2117-24 |year= 1991 |pmid= 1979339 |doi= }}
* {{cite journal | vauthors = Chen P, Mayne M, Power C, Nath A | title = The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases. | journal = J. Biol. Chem. | volume = 272 | issue = 36 | pages = 22385–8 | year = 1997 | pmid = 9278385 | doi = 10.1074/jbc.272.36.22385 }}
*{{cite journal | author=Zauli G, Previati M, Caramelli E, ''et al.'' |title=Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line. |journal=Eur. J. Immunol. |volume=25 |issue= 9 |pages= 2695-700 |year= 1995 |pmid= 7589147 |doi= }}
* {{cite journal | vauthors = Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C | title = HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease. | journal = Neuroimmunomodulation | volume = 5 | issue = 3–4 | pages = 184–92 | year = 1998 | pmid = 9730685 | doi = 10.1159/000026336 }}
*{{cite journal | author=Chen P, Mayne M, Power C, Nath A |title=The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22385-8 |year= 1997 |pmid= 9278385 |doi= }}
* {{cite journal | vauthors = Haughey NJ, Holden CP, Nath A, Geiger JD | title = Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat | journal = J. Neurochem. | volume = 73 | issue = 4 | pages = 1363–74 | year = 1999 | pmid = 10501179 | doi = 10.1046/j.1471-4159.1999.0731363.x }}
*{{cite journal | author=Mayne M, Bratanich AC, Chen P, ''et al.'' |title=HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease. |journal=Neuroimmunomodulation |volume=5 |issue= 3-4 |pages= 184-92 |year= 1998 |pmid= 9730685 |doi= }}
* {{cite journal | vauthors = Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 7 | issue = 2 | pages = 143–50 | year = 2000 | pmid = 10819331 | doi = 10.1093/dnares/7.2.143 }}
*{{cite journal | author=Haughey NJ, Holden CP, Nath A, Geiger JD |title=Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat. |journal=J. Neurochem. |volume=73 |issue= 4 |pages= 1363-74 |year= 1999 |pmid= 10501179 |doi= }}
* {{cite journal | vauthors = Mayne M, Holden CP, Nath A, Geiger JD | title = Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages | journal = J. Immunol. | volume = 164 | issue = 12 | pages = 6538–42 | year = 2000 | pmid = 10843712 | doi = 10.4049/jimmunol.164.12.6538 }}
*{{cite journal | author=Nagase T, Kikuno R, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 2 |pages= 143-50 |year= 2000 |pmid= 10819331 |doi= }}
* {{cite journal | vauthors = Jin TG, Satoh T, Liao Y, Song C, Gao X, Kariya K, Hu CD, Kataoka T | title = Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling | journal = J. Biol. Chem. | volume = 276 | issue = 32 | pages = 30301–7 | year = 2001 | pmid = 11395506 | doi = 10.1074/jbc.M103530200 }}
*{{cite journal | author=Mayne M, Holden CP, Nath A, Geiger JD |title=Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages. |journal=J. Immunol. |volume=164 |issue= 12 |pages= 6538-42 |year= 2000 |pmid= 10843712 |doi= }}
* {{cite journal | vauthors = Schmidt M, Evellin S, Weernink PA, von Dorp F, Rehmann H, Lomasney JW, Jakobs KH | title = A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase | journal = Nat. Cell Biol. | volume = 3 | issue = 11 | pages = 1020–4 | year = 2001 | pmid = 11715024 | doi = 10.1038/ncb1101-1020 }}
*{{cite journal | author=Lopez I, Mak EC, Ding J, ''et al.'' |title=A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway. |journal=J. Biol. Chem. |volume=276 |issue= 4 |pages= 2758-65 |year= 2001 |pmid= 11022047 |doi= 10.1074/jbc.M008119200 }}
* {{cite journal | vauthors = Evellin S, Nolte J, Tysack K, vom Dorp F, Thiel M, Weernink PA, Jakobs KH, Webb EJ, Lomasney JW, Schmidt M | title = Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B | journal = J. Biol. Chem. | volume = 277 | issue = 19 | pages = 16805–13 | year = 2002 | pmid = 11877431 | doi = 10.1074/jbc.M112024200 }}
*{{cite journal | author=Song C, Hu CD, Masago M, ''et al.'' |title=Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras. |journal=J. Biol. Chem. |volume=276 |issue= 4 |pages= 2752-7 |year= 2001 |pmid= 11022048 |doi= 10.1074/jbc.M008324200 }}
* {{cite journal | vauthors = Song C, Satoh T, Edamatsu H, Wu D, Tadano M, Gao X, Kataoka T | title = Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon | journal = Oncogene | volume = 21 | issue = 53 | pages = 8105–13 | year = 2002 | pmid = 12444546 | doi = 10.1038/sj.onc.1206003 }}
*{{cite journal | author=Jin TG, Satoh T, Liao Y, ''et al.'' |title=Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling. |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 30301-7 |year= 2001 |pmid= 11395506 |doi= 10.1074/jbc.M103530200 }}
* {{cite journal | vauthors = Bennasser Y, Badou A, Tkaczuk J, Bahraoui E | title = Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha | journal = Virology | volume = 303 | issue = 1 | pages = 174–80 | year = 2003 | pmid = 12482669 | doi = 10.1006/viro.2002.1676 }}
*{{cite journal | author=Schmidt M, Evellin S, Weernink PA, ''et al.'' |title=A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase. |journal=Nat. Cell Biol. |volume=3 |issue= 11 |pages= 1020-4 |year= 2001 |pmid= 11715024 |doi= 10.1038/ncb1101-1020 }}
* {{cite journal | vauthors = Czyzyk J, Brogdon JL, Badou A, Henegariu O, Preston Hurlburt P, Flavell R, Bottomly K | title = Activation of CD4 T cells by Raf-independent effectors of Ras | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 10 | pages = 6003–8 | year = 2003 | pmid = 12721365 | pmc = 156316 | doi = 10.1073/pnas.1031494100 }}
*{{cite journal | author=Evellin S, Nolte J, Tysack K, ''et al.'' |title=Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 16805-13 |year= 2002 |pmid= 11877431 |doi= 10.1074/jbc.M112024200 }}
* {{cite journal | vauthors = Lennartsson J, Wernstedt C, Engström U, Hellman U, Rönnstrand L | title = Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk | journal = Exp. Cell Res. | volume = 288 | issue = 1 | pages = 110–8 | year = 2003 | pmid = 12878163 | doi = 10.1016/S0014-4827(03)00206-4 }}
*{{cite journal | author=Song C, Satoh T, Edamatsu H, ''et al.'' |title=Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon. |journal=Oncogene |volume=21 |issue= 53 |pages= 8105-13 |year= 2002 |pmid= 12444546 |doi= 10.1038/sj.onc.1206003 }}
* {{cite journal | vauthors = vom Dorp F, Sari AY, Sanders H, Keiper M, Oude Weernink PA, Jakobs KH, Schmidt M | title = Inhibition of phospholipase C-epsilon by Gi-coupled receptors | journal = Cell. Signal. | volume = 16 | issue = 8 | pages = 921–8 | year = 2005 | pmid = 15157671 | doi = 10.1016/j.cellsig.2004.01.009 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Bennasser Y, Badou A, Tkaczuk J, Bahraoui E |title=Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha. |journal=Virology |volume=303 |issue= 1 |pages= 174-80 |year= 2003 |pmid= 12482669 |doi=  }}
*{{cite journal  | author=Czyzyk J, Brogdon JL, Badou A, ''et al.'' |title=Activation of CD4 T cells by Raf-independent effectors of Ras. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 10 |pages= 6003-8 |year= 2003 |pmid= 12721365 |doi= 10.1073/pnas.1031494100 }}
*{{cite journal  | author=Lennartsson J, Wernstedt C, Engström U, ''et al.'' |title=Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk. |journal=Exp. Cell Res. |volume=288 |issue= 1 |pages= 110-8 |year= 2003 |pmid= 12878163 |doi=  }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=vom Dorp F, Sari AY, Sanders H, ''et al.'' |title=Inhibition of phospholipase C-epsilon by Gi-coupled receptors. |journal=Cell. Signal. |volume=16 |issue= 8 |pages= 921-8 |year= 2005 |pmid= 15157671 |doi= 10.1016/j.cellsig.2004.01.009 }}
}}
{{refend}}
{{refend}}


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Revision as of 01:59, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1 is an enzyme that in humans is encoded by the PLCE1 gene.[1][2][3]

Function

PLCE1 belongs to the phospholipase family that catalyzes the hydrolysis of polyphosphoinositides such as phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) to generate the second messengers Ins(1,4,5)P3 and diacylglycerol. These products initiate a cascade of intracellular responses that result in cell growth and differentiation and gene expression.[supplied by OMIM][3]

References

  1. ↑ Lopez I, Mak EC, Ding J, Hamm HE, Lomasney JW (May 2001). "A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway". J Biol Chem. 276 (4): 2758–65. doi:10.1074/jbc.M008119200. PMID 11022047.
  2. ↑ Song C, Hu CD, Masago M, Kariyai K, Yamawaki-Kataoka Y, Shibatohge M, Wu D, Satoh T, Kataoka T (May 2001). "Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras". J Biol Chem. 276 (4): 2752–7. doi:10.1074/jbc.M008324200. PMID 11022048.
  3. ↑ 3.0 3.1 "Entrez Gene: PLCE1 phospholipase C, epsilon 1".

Further reading

  • Jefferson JA, Shankland SJ (2007). "Familial nephrotic syndrome: PLCE1 enters the fray". Nephrol. Dial. Transplant. 22 (7): 1849–52. doi:10.1093/ndt/gfm098. PMID 17449496.
  • Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G (1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". J. Clin. Invest. 86 (6): 2117–24. doi:10.1172/JCI114950. PMC 329852. PMID 1979339.
  • Zauli G, Previati M, Caramelli E, Bassini A, Falcieri E, Gibellini D, Bertolaso L, Bosco D, Robuffo I, Capitani S (1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line". Eur. J. Immunol. 25 (9): 2695–700. doi:10.1002/eji.1830250944. PMID 7589147.
  • Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". J. Biol. Chem. 272 (36): 22385–8. doi:10.1074/jbc.272.36.22385. PMID 9278385.
  • Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation. 5 (3–4): 184–92. doi:10.1159/000026336. PMID 9730685.
  • Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat". J. Neurochem. 73 (4): 1363–74. doi:10.1046/j.1471-4159.1999.0731363.x. PMID 10501179.
  • Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
  • Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". J. Immunol. 164 (12): 6538–42. doi:10.4049/jimmunol.164.12.6538. PMID 10843712.
  • Jin TG, Satoh T, Liao Y, Song C, Gao X, Kariya K, Hu CD, Kataoka T (2001). "Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling". J. Biol. Chem. 276 (32): 30301–7. doi:10.1074/jbc.M103530200. PMID 11395506.
  • Schmidt M, Evellin S, Weernink PA, von Dorp F, Rehmann H, Lomasney JW, Jakobs KH (2001). "A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase". Nat. Cell Biol. 3 (11): 1020–4. doi:10.1038/ncb1101-1020. PMID 11715024.
  • Evellin S, Nolte J, Tysack K, vom Dorp F, Thiel M, Weernink PA, Jakobs KH, Webb EJ, Lomasney JW, Schmidt M (2002). "Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B". J. Biol. Chem. 277 (19): 16805–13. doi:10.1074/jbc.M112024200. PMID 11877431.
  • Song C, Satoh T, Edamatsu H, Wu D, Tadano M, Gao X, Kataoka T (2002). "Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon". Oncogene. 21 (53): 8105–13. doi:10.1038/sj.onc.1206003. PMID 12444546.
  • Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669.
  • Czyzyk J, Brogdon JL, Badou A, Henegariu O, Preston Hurlburt P, Flavell R, Bottomly K (2003). "Activation of CD4 T cells by Raf-independent effectors of Ras". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6003–8. doi:10.1073/pnas.1031494100. PMC 156316. PMID 12721365.
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