SNRPD3: Difference between revisions

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Latest revision as of 06:46, 11 September 2017

Small nuclear ribonucleoprotein Sm D3 is a protein that in humans is encoded by the SNRPD3 gene.^[1]^[2]^[3]

Function

The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis.^[3]

Interactions

SNRPD3 has been shown to interact with:

CDC5L,^[4]
CLNS1A,^[5]
DDX20,^[6] and
Protein arginine methyltransferase 5.^[5]

References

↑ Lehmeier T, Foulaki K, Lührmann R (January 1991). "Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5". Nucleic Acids Res. 18 (22): 6475–84. doi:10.1093/nar/18.22.6475. PMC 332598. PMID 1701240.
↑ Lehmeier T, Raker V, Hermann H, Lührmann R (January 1995). "cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction". Proc Natl Acad Sci U S A. 91 (25): 12317–21. doi:10.1073/pnas.91.25.12317. PMC 45428. PMID 7527560.
↑ ^3.0 ^3.1 "Entrez Gene: SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa".
↑ Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
↑ ^5.0 ^5.1 Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G (Dec 2001). "The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins". Mol. Cell. Biol. 21 (24): 8289–300. doi:10.1128/MCB.21.24.8289-8300.2001. PMC 99994. PMID 11713266.
↑ Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (Dec 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.

Liu Q, Fischer U, Wang F, Dreyfuss G (1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013–21. doi:10.1016/S0092-8674(00)80367-0. PMID 9323129.
Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.
Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Lührmann R, Li J, Nagai K (1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs". Cell. 96 (3): 375–87. doi:10.1016/S0092-8674(00)80550-4. PMID 10025403.
Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (2000). "Gemin3: A Novel Dead Box Protein That Interacts with Smn, the Spinal Muscular Atrophy Gene Product, and Is a Component of Gems". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G (2000). "Gemin4: A Novel Component of the Smn Complex That Is Found in Both Gems and Nucleoli". J. Cell Biol. 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC 2174312. PMID 10725331.
Brahms H, Raymackers J, Union A, de Keyser F, Meheus L, Lührmann R (2000). "The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies". J. Biol. Chem. 275 (22): 17122–9. doi:10.1074/jbc.M000300200. PMID 10747894.
Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (2001). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
Urlaub H, Raker VA, Kostka S, Lührmann R (2001). "Sm protein–Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". EMBO J. 20 (1–2): 187–96. doi:10.1093/emboj/20.1.187. PMC 140196. PMID 11226169.
Friesen WJ, Massenet S, Paushkin S, Wyce A, Dreyfuss G (2001). "SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets". Mol. Cell. 7 (5): 1111–7. doi:10.1016/S1097-2765(01)00244-1. PMID 11389857.
Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G (2001). "The Methylosome, a 20S Complex Containing JBP1 and pICln, Produces Dimethylarginine-Modified Sm Proteins". Mol. Cell. Biol. 21 (24): 8289–300. doi:10.1128/MCB.21.24.8289-8300.2001. PMC 99994. PMID 11713266.
Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G (2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". J. Biol. Chem. 277 (7): 5631–6. doi:10.1074/jbc.M109448200. PMID 11714716.
Meister G, Eggert C, Bühler D, Brahms H, Kambach C, Fischer U (2002). "Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln". Curr. Biol. 11 (24): 1990–4. doi:10.1016/S0960-9822(01)00592-9. PMID 11747828.
Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". J. Biol. Chem. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". J. Biol. Chem. 277 (10): 8243–7. doi:10.1074/jbc.M109984200. PMID 11756452.
Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation". Nature. 414 (6866): 929–33. doi:10.1038/414929a. PMID 11780068.
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". J. Biol. Chem. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[pmid1701240-1] Lehmeier T, Foulaki K, Lührmann R (January 1991). "Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5". Nucleic Acids Res. 18 (22): 6475–84. doi:10.1093/nar/18.22.6475. PMC 332598. PMID 1701240.

[pmid7527560-2] Lehmeier T, Raker V, Hermann H, Lührmann R (January 1995). "cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction". Proc Natl Acad Sci U S A. 91 (25): 12317–21. doi:10.1073/pnas.91.25.12317. PMC 45428. PMID 7527560.

[entrez-3] 3.0 ^3.1 "Entrez Gene: SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa".

[pmid11101529-4] Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.

[pmid11713266-5] 5.0 ^5.1 Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G (Dec 2001). "The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins". Mol. Cell. Biol. 21 (24): 8289–300. doi:10.1128/MCB.21.24.8289-8300.2001. PMC 99994. PMID 11713266.

[pmid10601333-6] Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (Dec 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.

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[2]

[3]

[4]

[5]

[6]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Small nuclear ribonucleoprotein Sm D3''' is a [[protein]] that in humans is encoded by the ''SNRPD3'' [[gene]].<ref name="pmid1701240">{{cite journal | vauthors = Lehmeier T, Foulaki K, Lührmann R | title = Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5 | journal = Nucleic Acids Res | volume = 18 | issue = 22 | pages = 6475–84 | date = January 1991 | pmid = 1701240 | pmc = 332598 | doi = 10.1093/nar/18.22.6475 }}</ref><ref name="pmid7527560">{{cite journal | vauthors = Lehmeier T, Raker V, Hermann H, Lührmann R | title = cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction | journal = Proc Natl Acad Sci U S A | volume = 91 | issue = 25 | pages = 12317–21 | date = January 1995 | pmid = 7527560 | pmc = 45428 | doi = 10.1073/pnas.91.25.12317 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6634| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image = PBB_Protein_SNRPD3_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1d3b.
- | PDB = {{PDB2|1d3b}}
- | Name = Small nuclear ribonucleoprotein D3 polypeptide 18kDa
- | HGNCid = 11160
- | Symbol = SNRPD3
- | AltSymbols =; SMD3
- | OMIM = 601062
- | ECnumber =
- | Homologene = 3078
- | MGIid = 1914582
- | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0030532 |text = small nuclear ribonucleoprotein complex}}
- | Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 6634
-    | Hs_Ensembl = ENSG00000100028
-    | Hs_RefseqProtein = NP_004166
-    | Hs_RefseqmRNA = NM_004175
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 22
-    | Hs_GenLoc_start = 23281618
-    | Hs_GenLoc_end = 23298509
-    | Hs_Uniprot = P62318
-    | Mm_EntrezGene = 67332
-    | Mm_Ensembl = ENSMUSG00000020180
-    | Mm_RefseqmRNA = NM_026095
-    | Mm_RefseqProtein = NP_080371
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 10
-    | Mm_GenLoc_start = 74961737
-    | Mm_GenLoc_end = 74979181
-    | Mm_Uniprot = Q91VM2
-  }}
-}}
-'''Small nuclear ribonucleoprotein D3 polypeptide 18kDa''', also known as '''SNRPD3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6634| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis.<ref name="entrez" />
-{{PBB_Summary
-| section_title =
-| summary_text = The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis.<ref name="entrez">{{cite web | title = Entrez Gene: SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6634| accessdate = }}</ref>
-}}
-==References==
+== Interactions ==
-{{reflist|2}}
-==Further reading==
-{{refbegin | 2}}
-{{PBB_Further_reading
-| citations =
-*{{cite journal  | author=Lehmeier T, Foulaki K, Lührmann R |title=Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5. |journal=Nucleic Acids Res. |volume=18 |issue= 22 |pages= 6475-84 |year= 1991 |pmid= 1701240 |doi=  }}
-*{{cite journal  | author=Lehmeier T, Raker V, Hermann H, Lührmann R |title=cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 25 |pages= 12317-21 |year= 1995 |pmid= 7527560 |doi=  }}
-*{{cite journal  | author=Liu Q, Fischer U, Wang F, Dreyfuss G |title=The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins. |journal=Cell |volume=90 |issue= 6 |pages= 1013-21 |year= 1997 |pmid= 9323129 |doi=  }}
-*{{cite journal  | author=Fury MG, Zhang W, Christodoulopoulos I, Zieve GW |title=Multiple protein: protein interactions between the snRNP common core proteins. |journal=Exp. Cell Res. |volume=237 |issue= 1 |pages= 63-9 |year= 1998 |pmid= 9417867 |doi= 10.1006/excr.1997.3750 }}
-*{{cite journal  | author=Kambach C, Walke S, Young R, ''et al.'' |title=Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs. |journal=Cell |volume=96 |issue= 3 |pages= 375-87 |year= 1999 |pmid= 10025403 |doi=  }}
-*{{cite journal  | author=Charroux B, Pellizzoni L, Perkinson RA, ''et al.'' |title=Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems. |journal=J. Cell Biol. |volume=147 |issue= 6 |pages= 1181-94 |year= 2000 |pmid= 10601333 |doi=  }}
-*{{cite journal  | author=Charroux B, Pellizzoni L, Perkinson RA, ''et al.'' |title=Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli. |journal=J. Cell Biol. |volume=148 |issue= 6 |pages= 1177-86 |year= 2000 |pmid= 10725331 |doi=  }}
-*{{cite journal  | author=Brahms H, Raymackers J, Union A, ''et al.'' |title=The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies. |journal=J. Biol. Chem. |volume=275 |issue= 22 |pages= 17122-9 |year= 2000 |pmid= 10747894 |doi= 10.1074/jbc.M000300200 }}
-*{{cite journal  | author=Ajuh P, Kuster B, Panov K, ''et al.'' |title=Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. |journal=EMBO J. |volume=19 |issue= 23 |pages= 6569-81 |year= 2001 |pmid= 11101529 |doi= 10.1093/emboj/19.23.6569 }}
-*{{cite journal  | author=Urlaub H, Raker VA, Kostka S, Lührmann R |title=Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure. |journal=EMBO J. |volume=20 |issue= 1-2 |pages= 187-96 |year= 2001 |pmid= 11226169 |doi= 10.1093/emboj/20.1.187 }}
-*{{cite journal  | author=Friesen WJ, Massenet S, Paushkin S, ''et al.'' |title=SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets. |journal=Mol. Cell |volume=7 |issue= 5 |pages= 1111-7 |year= 2001 |pmid= 11389857 |doi=  }}
-*{{cite journal  | author=Friesen WJ, Paushkin S, Wyce A, ''et al.'' |title=The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins. |journal=Mol. Cell. Biol. |volume=21 |issue= 24 |pages= 8289-300 |year= 2001 |pmid= 11713266 |doi= 10.1128/MCB.21.24.8289-8300.2001 }}
-*{{cite journal  | author=Gubitz AK, Mourelatos Z, Abel L, ''et al.'' |title=Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 5631-6 |year= 2002 |pmid= 11714716 |doi= 10.1074/jbc.M109448200 }}
-*{{cite journal  | author=Meister G, Eggert C, Bühler D, ''et al.'' |title=Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln. |journal=Curr. Biol. |volume=11 |issue= 24 |pages= 1990-4 |year= 2002 |pmid= 11747828 |doi=  }}
-*{{cite journal  | author=Pellizzoni L, Baccon J, Rappsilber J, ''et al.'' |title=Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7540-5 |year= 2002 |pmid= 11748230 |doi= 10.1074/jbc.M110141200 }}
-*{{cite journal  | author=Friesen WJ, Wyce A, Paushkin S, ''et al.'' |title=A novel WD repeat protein component of the methylosome binds Sm proteins. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8243-7 |year= 2002 |pmid= 11756452 |doi= 10.1074/jbc.M109984200 }}
-*{{cite journal  | author=Fong YW, Zhou Q |title=Stimulatory effect of splicing factors on transcriptional elongation. |journal=Nature |volume=414 |issue= 6866 |pages= 929-33 |year= 2002 |pmid= 11780068 |doi= 10.1038/414929a }}
-*{{cite journal  | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi=  }}
-*{{cite journal  | author=Jurica MS, Licklider LJ, Gygi SR, ''et al.'' |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426-39 |year= 2002 |pmid= 11991638 |doi=  }}
-*{{cite journal  | author=Baccon J, Pellizzoni L, Rappsilber J, ''et al.'' |title=Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31957-62 |year= 2002 |pmid= 12065586 |doi= 10.1074/jbc.M203478200 }}
-}}
-{{refend}}
-{{gene-22-stub}}
+SNRPD3 has been shown to [[Protein-protein interaction|interact]] with:
-{{WikiDoc Sources}}
+* [[CDC5L]],<ref name = pmid11101529>{{cite journal | vauthors = Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI | title = Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry | journal = EMBO J. | volume = 19 | issue = 23 | pages = 6569–81 | date = Dec 2000 | pmid = 11101529 | pmc = 305846 | doi = 10.1093/emboj/19.23.6569 }}</ref>
+* [[CLNS1A]],<ref name = pmid11713266>{{cite journal | vauthors = Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G | title = The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins | journal = Mol. Cell. Biol. | volume = 21 | issue = 24 | pages = 8289–300 | date = Dec 2001 | pmid = 11713266 | pmc = 99994 | doi = 10.1128/MCB.21.24.8289-8300.2001 }}</ref>
+* [[DDX20]],<ref name = pmid10601333>{{cite journal | vauthors = Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G | title = Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems | journal = J. Cell Biol. | volume = 147 | issue = 6 | pages = 1181–94 | date = Dec 1999 | pmid = 10601333 | pmc = 2168095 | doi =  10.1083/jcb.147.6.1181}}</ref>  and
+* [[Protein arginine methyltransferase 5]].<ref name = pmid11713266/>
+== References ==
+{{Reflist}}
+== Further reading ==
+{{Refbegin | 2}}
+* {{cite journal | vauthors = Liu Q, Fischer U, Wang F, Dreyfuss G | title = The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins | journal = Cell | volume = 90 | issue = 6 | pages = 1013–21 | year = 1997 | pmid = 9323129 | doi = 10.1016/S0092-8674(00)80367-0 }}
+* {{cite journal | vauthors = Fury MG, Zhang W, Christodoulopoulos I, Zieve GW | title = Multiple protein: protein interactions between the snRNP common core proteins | journal = Exp. Cell Res. | volume = 237 | issue = 1 | pages = 63–9 | year = 1998 | pmid = 9417867 | doi = 10.1006/excr.1997.3750 }}
+* {{cite journal | vauthors = Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Lührmann R, Li J, Nagai K | title = Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs | journal = Cell | volume = 96 | issue = 3 | pages = 375–87 | year = 1999 | pmid = 10025403 | doi = 10.1016/S0092-8674(00)80550-4 }}
+* {{cite journal | vauthors = Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G | title = Gemin3: A Novel Dead Box Protein That Interacts with Smn, the Spinal Muscular Atrophy Gene Product, and Is a Component of Gems | journal = J. Cell Biol. | volume = 147 | issue = 6 | pages = 1181–94 | year = 2000 | pmid = 10601333 | pmc = 2168095 | doi = 10.1083/jcb.147.6.1181 }}
+* {{cite journal | vauthors = Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G | title = Gemin4: A Novel Component of the Smn Complex That Is Found in Both Gems and Nucleoli | journal = J. Cell Biol. | volume = 148 | issue = 6 | pages = 1177–86 | year = 2000 | pmid = 10725331 | pmc = 2174312 | doi = 10.1083/jcb.148.6.1177 }}
+* {{cite journal | vauthors = Brahms H, Raymackers J, Union A, de Keyser F, Meheus L, Lührmann R | title = The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies | journal = J. Biol. Chem. | volume = 275 | issue = 22 | pages = 17122–9 | year = 2000 | pmid = 10747894 | doi = 10.1074/jbc.M000300200 }}
+* {{cite journal | vauthors = Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI | title = Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry | journal = EMBO J. | volume = 19 | issue = 23 | pages = 6569–81 | year = 2001 | pmid = 11101529 | pmc = 305846 | doi = 10.1093/emboj/19.23.6569 }}
+* {{cite journal | vauthors = Urlaub H, Raker VA, Kostka S, Lührmann R | title = Sm protein–Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure | journal = EMBO J. | volume = 20 | issue = 1–2 | pages = 187–96 | year = 2001 | pmid = 11226169 | pmc = 140196 | doi = 10.1093/emboj/20.1.187 }}
+* {{cite journal | vauthors = Friesen WJ, Massenet S, Paushkin S, Wyce A, Dreyfuss G | title = SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets | journal = Mol. Cell | volume = 7 | issue = 5 | pages = 1111–7 | year = 2001 | pmid = 11389857 | doi = 10.1016/S1097-2765(01)00244-1 }}
+* {{cite journal | vauthors = Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G | title = The Methylosome, a 20S Complex Containing JBP1 and pICln, Produces Dimethylarginine-Modified Sm Proteins | journal = Mol. Cell. Biol. | volume = 21 | issue = 24 | pages = 8289–300 | year = 2001 | pmid = 11713266 | pmc = 99994 | doi = 10.1128/MCB.21.24.8289-8300.2001 }}
+* {{cite journal | vauthors = Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G | title = Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins | journal = J. Biol. Chem. | volume = 277 | issue = 7 | pages = 5631–6 | year = 2002 | pmid = 11714716 | doi = 10.1074/jbc.M109448200 }}
+* {{cite journal | vauthors = Meister G, Eggert C, Bühler D, Brahms H, Kambach C, Fischer U | title = Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln | journal = Curr. Biol. | volume = 11 | issue = 24 | pages = 1990–4 | year = 2002 | pmid = 11747828 | doi = 10.1016/S0960-9822(01)00592-9 }}
+* {{cite journal | vauthors = Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G | title = Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component | journal = J. Biol. Chem. | volume = 277 | issue = 9 | pages = 7540–5 | year = 2002 | pmid = 11748230 | doi = 10.1074/jbc.M110141200 }}
+* {{cite journal | vauthors = Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G | title = A novel WD repeat protein component of the methylosome binds Sm proteins | journal = J. Biol. Chem. | volume = 277 | issue = 10 | pages = 8243–7 | year = 2002 | pmid = 11756452 | doi = 10.1074/jbc.M109984200 }}
+* {{cite journal | vauthors = Fong YW, Zhou Q | title = Stimulatory effect of splicing factors on transcriptional elongation | journal = Nature | volume = 414 | issue = 6866 | pages = 929–33 | year = 2002 | pmid = 11780068 | doi = 10.1038/414929a }}
+* {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Curr. Biol. | volume = 12 | issue = 1 | pages = 1–11 | year = 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 }}
+* {{cite journal | vauthors = Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ | title = Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis | journal = RNA | volume = 8 | issue = 4 | pages = 426–39 | year = 2002 | pmid = 11991638 | pmc = 1370266 | doi = 10.1017/S1355838202021088 }}
+* {{cite journal | vauthors = Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G | title = Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex | journal = J. Biol. Chem. | volume = 277 | issue = 35 | pages = 31957–62 | year = 2002 | pmid = 12065586 | doi = 10.1074/jbc.M203478200 }}
+{{Refend}}
+{{PDB Gallery|geneid=6634}}
+{{Ribonucleoproteins}}
+{{Gene-22-stub}}

v t e RNA-binding protein: Ribonucleoproteins
snRNP	A A1 B B2 C D1 D2 D3 E F G N 70K/U1 spliceosomal RNA SNRNP200
hnRNP	A0 C L R
Other transcription	Telomerase
Translation	Ribosome
Vault ribonucleoprotein particles	Major vault protein
Other	Signal recognition particle

SNRPD3: Difference between revisions

Latest revision as of 06:46, 11 September 2017

Contents

Function

Interactions

References

Further reading

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