Hairy cell leukemia laboratory tests: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
* The diagnostic path may have begun with a simple test like a [[complete blood count]], but this is not adequate to diagnose HCL. A CBC normally shows low counts for white blood cells, red blood cells, and platelets in HCL patients, but if large numbers of hairy cells are in the blood stream, then normal or even [[lymphocytosis|high lymphocyte counts]] may be found. | |||
Patients with a high tumor burden may also have somewhat reduced levels of cholesterol,<ref>{{cite web |url=http://www3.interscience.wiley.com/cgi-bin/abstract/50446/ABSTRACT?CRETRY=1&SRETRY=0 |title=wiley.com |accessdate=2007-09-07 |format= |work=}}</ref> especially in patients with an enlarged spleen.<ref>{{cite web |url=http://www.bmj.com/cgi/content/full/311/6996/27 |title=Mechanisms behind hypocholesterolaemia in hairy cell leukaemia -- Juliusson et al. 311 (6996): 27 -- BMJ |accessdate=2007-09-07 |format= |work=}}</ref> Cholesterol levels return to more normal values with successful treatment of HCL. | * Platelet function may be somewhat impaired in HCL patients, although this does not appear to have any significant practical effect.<ref name="pmid512041">{{cite journal |author=Zuzel M, Cawley JC, Paton RC, Burns GF, McNicol GP |title=Platelet function in hairy-cell leukaemia |journal=J. Clin. Pathol. |volume=32 |issue=8 |pages=814-21 |year=1979 |pmid=512041 |doi=}}</ref> It may result in somewhat more mild bruises than would otherwise be expected for a given platelet count or a mildly increased bleeding time for a minor cut. It is likely the result of producing slightly abnormal platelets in the overstressed bone marrow tissue. | ||
* Patients with a high tumor burden may also have somewhat reduced levels of cholesterol,<ref>{{cite web |url=http://www3.interscience.wiley.com/cgi-bin/abstract/50446/ABSTRACT?CRETRY=1&SRETRY=0 |title=wiley.com |accessdate=2007-09-07 |format= |work=}}</ref> especially in patients with an enlarged spleen.<ref>{{cite web |url=http://www.bmj.com/cgi/content/full/311/6996/27 |title=Mechanisms behind hypocholesterolaemia in hairy cell leukaemia -- Juliusson et al. 311 (6996): 27 -- BMJ |accessdate=2007-09-07 |format= |work=}}</ref> Cholesterol levels return to more normal values with successful treatment of HCL. | |||
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Image:Hairy cell leukemia 0001.jpg|Hairy cell leukemia | Image:Hairy cell leukemia 0001.jpg|Hairy cell leukemia | ||
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Image:Hairy Cell Leukemia.jpg|Hairy Cell Leukemia | |||
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Revision as of 14:31, 17 September 2012
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Hairy cell leukemia laboratory tests On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Hairy cell leukemia is commonly diagnosed after a routine blood count shows unexpectedly low numbers for one or more kinds of blood cells, or after unexplained bruises or unexplained infections, such as repeated bouts of pneumonia in an otherwise apparently healthy patient.
Laboratory Findings
- The diagnostic path may have begun with a simple test like a complete blood count, but this is not adequate to diagnose HCL. A CBC normally shows low counts for white blood cells, red blood cells, and platelets in HCL patients, but if large numbers of hairy cells are in the blood stream, then normal or even high lymphocyte counts may be found.
- Platelet function may be somewhat impaired in HCL patients, although this does not appear to have any significant practical effect.[1] It may result in somewhat more mild bruises than would otherwise be expected for a given platelet count or a mildly increased bleeding time for a minor cut. It is likely the result of producing slightly abnormal platelets in the overstressed bone marrow tissue.
- Patients with a high tumor burden may also have somewhat reduced levels of cholesterol,[2] especially in patients with an enlarged spleen.[3] Cholesterol levels return to more normal values with successful treatment of HCL.
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Hairy cell leukemia -
Hairy cell leukemia TEM -
Hairy Cell Leukemia
References
- ↑ Zuzel M, Cawley JC, Paton RC, Burns GF, McNicol GP (1979). "Platelet function in hairy-cell leukaemia". J. Clin. Pathol. 32 (8): 814–21. PMID 512041.
- ↑ "wiley.com". Retrieved 2007-09-07.
- ↑ "Mechanisms behind hypocholesterolaemia in hairy cell leukaemia -- Juliusson et al. 311 (6996): 27 -- BMJ". Retrieved 2007-09-07.