Aggressive NK-cell leukemia: Difference between revisions
| Line 17: | Line 17: | ||
'''Synonyms and related key words''': Aggressive natural killer cell leukemia; aggressive NK-cell leukemia; aggressive NK-cell lymphoma; large granular lymphocyte leukemia, NK-cell type | '''Synonyms and related key words''': Aggressive natural killer cell leukemia; aggressive NK-cell leukemia; aggressive NK-cell lymphoma; large granular lymphocyte leukemia, NK-cell type | ||
==Molecular findings== | ==Molecular findings== | ||
Revision as of 19:59, 18 September 2012
| Aggressive NK-cell leukemia | |
| ICD-O: | 9948/3 |
|---|---|
|
Aggressive NK-cell leukemia Microchapters |
|
Differentiating Aggressive NK-cell leukemia from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Aggressive NK-cell leukemia On the Web |
|
American Roentgen Ray Society Images of Aggressive NK-cell leukemia |
|
Directions to Hospitals Treating Aggressive NK-cell leukemia |
|
Risk calculators and risk factors for Aggressive NK-cell leukemia |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]
Synonyms and related key words: Aggressive natural killer cell leukemia; aggressive NK-cell leukemia; aggressive NK-cell lymphoma; large granular lymphocyte leukemia, NK-cell type
Molecular findings
Immunophenotype
The immunophenotype of this disease is the same as extranodal NK/T-cell lymphoma, nasal type and is shown in the table below. CD11b and CD16 show variable expression.[1][2]
| Status | Antigens |
| Positive | CD2, CD3ε, CD56, perforin, granzyme B, TIA-1 |
| Negative | CD57 |
Genetic findings
Due to the myeloid lineage, clonal rearrangements of lymphoid (T cell receptor; B cell receptor) genes are not seen.[3] The genome of the Epstein Barr virus (EBV) is detected in many cases[4], along with a variety of chromosomal abnormalities.[5]
Current articles
References
- ↑ Invalid
<ref>tag; no text was provided for refs namedcha1 - ↑ Invalid
<ref>tag; no text was provided for refs namedosh1 - ↑ Invalid
<ref>tag; no text was provided for refs namedwho1 - ↑ Invalid
<ref>tag; no text was provided for refs namedgel1 - ↑ [1] Wong KF, Zhang YM, Chan JK. "Cytogenetic abnormalities in natural killer cell lymphoma/leukaemia--is there a consistent pattern?" Leuk Lymphoma. 1999 Jul;34(3-4):241-50. PMID: 10439361