Aggressive NK-cell leukemia: Difference between revisions
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===Genetic findings=== | ===Genetic findings=== | ||
Due to the [[myeloid]] lineage, clonal rearrangements of [[lymphoid]] (T cell receptor; B cell receptor) genes are not seen. | Due to the [[myeloid]] lineage, clonal rearrangements of [[lymphoid]] (T cell receptor; B cell receptor) genes are not seen. The genome of the [[Epstein Barr virus]] (EBV) is detected in many cases<ref name="gel1"/>, along with a variety of chromosomal abnormalities.<ref name="won1">[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=10439361&query_hl=38&itool=pubmed_ExternalLink] | ||
Wong KF, Zhang YM, Chan JK. "Cytogenetic abnormalities in natural killer cell lymphoma/leukaemia--is there a consistent pattern?" '''Leuk Lymphoma'''. 1999 Jul;34(3-4):241-50. PMID: 10439361</ref> | Wong KF, Zhang YM, Chan JK. "Cytogenetic abnormalities in natural killer cell lymphoma/leukaemia--is there a consistent pattern?" '''Leuk Lymphoma'''. 1999 Jul;34(3-4):241-50. PMID: 10439361</ref> | ||
Revision as of 19:59, 18 September 2012
Aggressive NK-cell leukemia | |
ICD-O: | 9948/3 |
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Aggressive NK-cell leukemia Microchapters |
Differentiating Aggressive NK-cell leukemia from other Diseases |
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Diagnosis |
Treatment |
Case Studies |
Aggressive NK-cell leukemia On the Web |
American Roentgen Ray Society Images of Aggressive NK-cell leukemia |
Directions to Hospitals Treating Aggressive NK-cell leukemia |
Risk calculators and risk factors for Aggressive NK-cell leukemia |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]
Synonyms and related key words: Aggressive natural killer cell leukemia; aggressive NK-cell leukemia; aggressive NK-cell lymphoma; large granular lymphocyte leukemia, NK-cell type
Molecular findings
Immunophenotype
The immunophenotype of this disease is the same as extranodal NK/T-cell lymphoma, nasal type and is shown in the table below. CD11b and CD16 show variable expression.[1][2]
Status | Antigens |
Positive | CD2, CD3ε, CD56, perforin, granzyme B, TIA-1 |
Negative | CD57 |
Genetic findings
Due to the myeloid lineage, clonal rearrangements of lymphoid (T cell receptor; B cell receptor) genes are not seen. The genome of the Epstein Barr virus (EBV) is detected in many cases[3], along with a variety of chromosomal abnormalities.[4]
Current articles
References
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- ↑ [1] Wong KF, Zhang YM, Chan JK. "Cytogenetic abnormalities in natural killer cell lymphoma/leukaemia--is there a consistent pattern?" Leuk Lymphoma. 1999 Jul;34(3-4):241-50. PMID: 10439361