Aggressive NK-cell leukemia other diagnostic studies: Difference between revisions
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===Genetic Findings=== | ===Genetic Findings=== | ||
Due to the [[myeloid]] lineage, clonal rearrangements of [[lymphoid]] (T cell receptor; B cell receptor) genes are not seen. The genome of the [[Epstein Barr virus]] (EBV) is detected in many cases, along with a variety of chromosomal abnormalities.<ref name="won1">[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=10439361&query_hl=38&itool=pubmed_ExternalLink] | Due to the [[myeloid]] lineage, clonal rearrangements of [[lymphoid]] (T cell receptor; B cell receptor) genes are not seen. The genome of the [[Epstein Barr virus]] (EBV) is detected in many cases, along with a variety of chromosomal abnormalities.<ref name="won1">[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=10439361&query_hl=38&itool=pubmed_ExternalLink] | ||
Wong KF, Zhang YM, Chan JK. "Cytogenetic abnormalities in natural killer cell lymphoma/leukaemia--is there a consistent pattern?" '''Leuk Lymphoma'''. 1999 Jul;34(3-4):241-50. | Wong KF, Zhang YM, Chan JK. "Cytogenetic abnormalities in natural killer cell lymphoma/leukaemia--is there a consistent pattern?" '''Leuk Lymphoma'''. 1999 Jul;34(3-4):241-50. | ||
Revision as of 20:02, 18 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Molecular Findings
Immunophenotype
The immunophenotype of this disease is the same as extranodal NK/T-cell lymphoma, nasal type and is shown in the table below. CD11b and CD16 show variable expression.
| Status | Antigens |
| Positive | CD2, CD3ε, CD56, perforin, granzyme B, TIA-1 |
| Negative | CD57 |
References
Genetic Findings
Due to the myeloid lineage, clonal rearrangements of lymphoid (T cell receptor; B cell receptor) genes are not seen. The genome of the Epstein Barr virus (EBV) is detected in many cases, along with a variety of chromosomal abnormalities.<ref name="won1">[2] Wong KF, Zhang YM, Chan JK. "Cytogenetic abnormalities in natural killer cell lymphoma/leukaemia--is there a consistent pattern?" Leuk Lymphoma. 1999 Jul;34(3-4):241-50.