|
|
| Line 5: |
Line 5: |
| {{SK}}Histiocytic lymphoma, histiocytic lymphosarcoma | | {{SK}}Histiocytic lymphoma, histiocytic lymphosarcoma |
|
| |
|
| ==Overview==
| |
| A malignant tumor of reticular tissue in the bone that is composed primarily of neoplastic [[histocytes]].
| |
|
| |
| ==Pathophysiology==
| |
| The dominant cell type is thought to be derived from [[histiocytes]] or [[macrophages]]. More recent thinking indicates that this cancer may arise from [[lymphocytes]] or [[immunoblasts]].
| |
|
| |
| ==Differentiating Reticulum Cell Sarcoma From Other Diseases==
| |
| Reticulum cell sarcoma should be distinguished from the following diseases:
| |
| *[[Ewing's sarcoma]]
| |
| *[[Fibrosarcoma]]
| |
| *[[Malignant Fibrous Histiocytoma]]
| |
| *[[Metastatic carcinoma]]
| |
| *[[Osteomyelitis]]
| |
|
| |
| ==Epidemiology and Demographics==
| |
| *Presents in middle age
| |
|
| |
| ==Diagnosis==
| |
| ===Symptoms===
| |
| *Localized bone pain and tenderness
| |
|
| |
| ===Physical Examination===
| |
| *Tenderness of bone
| |
| *Effusion of adjacent joint
| |
|
| |
| ===Imaging Findings===
| |
| *Osteolytic lesions with minimal periosteal reactions are present on plain films of the bone
| |
|
| |
| ===Pathology===
| |
| *Large, foam filled [[histiocytes]] with numerous [[mitoses]] and scant stroma are present
| |
| *Stains for reticulum are positive
| |
| *[[Periodic Acid Schiff]] ([[PAS]]) stains are negative
| |
|
| |
| ==Treatment==
| |
| ===Early stage I tumors===
| |
| *[[Radiation therapy]] alone
| |
| ===Advanced Tumors===
| |
| *[[Radiation therapy]] plus [[chemotherapy]]
| |
|
| |
|
|
| |
|