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== Other Diagnostic Studies ==
== Other Diagnostic Studies ==
===Skin Biopsy===
Skin biopsy can be of value in establishing the diagnosis.


Skin biopsy can be of value in establishing the diagnosis.
===Renal Biopsy===
* The characteristic findings on renal biopsy are
*:# Intraluminal thrombi
*:# Diffuse [[IgM]] deposition in the capillary loops
*:# Subendothelial deposits in a “curvilinear” pattern on EM. 
* Only 14% develop end stage renal disease ([[ESRD]]) at 10 years after a renal biopsy demonstrates MC. 
* Recurrent MC can affect up to 70% of transplanted kidneys, but does not preclude transplantation since most of these grafts do not fail.


==References==
==References==

Revision as of 13:16, 21 September 2012

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]

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Overview

Other Diagnostic Studies

Skin Biopsy

Skin biopsy can be of value in establishing the diagnosis.

Renal Biopsy

  • The characteristic findings on renal biopsy are
    1. Intraluminal thrombi
    2. Diffuse IgM deposition in the capillary loops
    3. Subendothelial deposits in a “curvilinear” pattern on EM.
  • Only 14% develop end stage renal disease (ESRD) at 10 years after a renal biopsy demonstrates MC.
  • Recurrent MC can affect up to 70% of transplanted kidneys, but does not preclude transplantation since most of these grafts do not fail.

References


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