Folate deficiency causes: Difference between revisions
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(Created page with "__NOTOC__ {{Folate deficiency}} {{CMG}} ==Overview== ==Causes== A deficiency of folate can occur when your need for folate is increased, when dietary intake of folate is i...") |
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--><ref name="Oldref_18">{{cite journal | author=Pietrzik KF and Thorand B | title=Folate economy in pregnancy | journal=Nutrition | volume=13 | issue=11-12 | year=1997 | pages=975-7 | id=PMID 9433714}}</ref><!-- | --><ref name="Oldref_18">{{cite journal | author=Pietrzik KF and Thorand B | title=Folate economy in pregnancy | journal=Nutrition | volume=13 | issue=11-12 | year=1997 | pages=975-7 | id=PMID 9433714}}</ref><!-- | ||
--><ref name="Oldref_19">{{cite journal | author=Kelly GS | title=Folates: Supplemental forms and therapeutic applications | journal=Altern Med Rev | volume=3 | issue=3 | year=1998 | pages=208-20 | id=PMID 9630738}}</ref><!-- | --><ref name="Oldref_19">{{cite journal | author=Kelly GS | title=Folates: Supplemental forms and therapeutic applications | journal=Altern Med Rev | volume=3 | issue=3 | year=1998 | pages=208-20 | id=PMID 9630738}}</ref><!-- | ||
--><ref name="Oldref_17">{{cite journal | author=Cravo ML, Gloria LM, Selhub J, Nadeau MR, Camilo ME, Resende MP, Cardoso JN, Leitao CN, Mira FC | title=Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B-12, and vitamin B-6 status | journal=The American journal of clinical nutrition | volume=63 | issue=2 | year=1996 | pages=220-4 | id=PMID 8561063}}</ref> Some research indicates that exposure to [[ultraviolet light]], including the use of tanning beds, can lead to a folic acid deficiency. | --><ref name="Oldref_17">{{cite journal | author=Cravo ML, Gloria LM, Selhub J, Nadeau MR, Camilo ME, Resende MP, Cardoso JN, Leitao CN, Mira FC | title=Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B-12, and vitamin B-6 status | journal=The American journal of clinical nutrition | volume=63 | issue=2 | year=1996 | pages=220-4 | id=PMID 8561063}}</ref> Some research indicates that exposure to [[ultraviolet light]], including the use of tanning beds, can lead to a folic acid deficiency. The evolution of human [[skin color]] is partly controlled by the need to have dark skin in the tropics to protect folic acid from ultraviolet light. | ||
===Situational=== | ===Situational=== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Causes
A deficiency of folate can occur when your need for folate is increased, when dietary intake of folate is inadequate, and when your body excretes (or loses) more folate than usual. Medications that interfere with your body's ability to use folate may also increase the need for this vitamin.[1][2][3][4][5][6] Some research indicates that exposure to ultraviolet light, including the use of tanning beds, can lead to a folic acid deficiency. The evolution of human skin color is partly controlled by the need to have dark skin in the tropics to protect folic acid from ultraviolet light.
Situational
Some situations that increase the need for folate include:
- Pregnancy and lactation (breastfeeding)
- Alcoholism
- Tobacco smoking
- Malabsorption, including celiac disease
- Kidney dialysis
- Liver disease
- Certain anemias.
Medicational
Medications can interfere with folate utilization, including:
- Anticonvulsant medications (such as phenytoin, and primidone)
- Metformin (sometimes prescribed to control blood sugar in type 2 diabetes)
- Sulfasalazine (used to control inflammation associated with Crohn's disease, ulcerative colitis and rheumatoid arthritis)
- Triamterene (a diuretic)
- Methotrexate, an anti-cancer drug also used to control inflammation associated with Crohn's disease, ulcerative colitis and rheumatoid arthritis.
Inadequate Folate Intake
- Advanced age
- Alcohol abuse
- Celiac Disease
- Crohn's Disease
- Malabsorption
- Malnutrition
- Postoperative
- Ulcerateive colitis
- Vegetarians
Increased Folate Utilization
- Childhood
- Chronic blood loss
- Chronic hemolytic anemia
- Hyperthyroidism
- Lactation
- Leukemias
- Macrocytic anemia
- Other anemias
- Pregnancy
- Psoriasis
- Solid tumors
Other
- Congenital impairment of folic acid metabolism
- Drugs
- Enzyme defects
- Hematologic diseases
References
- ↑ Oakley GP Jr, Adams MJ, Dickinson CM (1996). "More folic acid for everyone, now". Journal of Nutrition. 126 (3): 751S–755S. PMID 8598560.
- ↑ McNulty H (1995). "Folate requirements for health in different population groups". British Journal of Biomedical Science. 52 (2): 110–9. PMID 8520248.
- ↑ Stolzenberg R (1994). "Possible folate deficiency with postsurgical infection". Nutrition in Clinical Practice. 9 (6): 247–50. PMID 7476802.
- ↑ Pietrzik KF and Thorand B (1997). "Folate economy in pregnancy". Nutrition. 13 (11–12): 975–7. PMID 9433714.
- ↑ Kelly GS (1998). "Folates: Supplemental forms and therapeutic applications". Altern Med Rev. 3 (3): 208–20. PMID 9630738.
- ↑ Cravo ML, Gloria LM, Selhub J, Nadeau MR, Camilo ME, Resende MP, Cardoso JN, Leitao CN, Mira FC (1996). "Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B-12, and vitamin B-6 status". The American journal of clinical nutrition. 63 (2): 220–4. PMID 8561063.