Sideroblastic anemia laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Laboratory findings

• Increased ferritin levels
• Decreased total iron-binding capacity
• Hematocrit of about 20-30%
• Serum Iron: High
• High transferrin saturation
• The mean corpuscular volume or MCV is usually normal or slightly increased; although it may occasionally be low, leading to confusion with iron deficiency.
• With lead poisoning, see coarse basophilic stippling of red blood cells on peripheral blood smear
• Specific test: Prussian Blue stain of RBC in marrow. Shows ringed sideroblasts.
• Ringed sideroblasts are seen in the bone marrow.