Diffuse panbronchiolitis history and symptoms: Difference between revisions
(Created page with "__NOTOC__ {{Diffuse panbronchiolitis}} {{CMG}} ==Overview== ==Symptoms== DPB can be characterized by a number of symptoms and histological features (tho...") |
|||
| Line 10: | Line 10: | ||
DPB can be characterized by a number of symptoms and [[histopathology|histological]] features (those detected by analysis of tissues). | DPB can be characterized by a number of symptoms and [[histopathology|histological]] features (those detected by analysis of tissues). | ||
These include: chronic [[bronchi]]al and bronchiolar inflammation, lung tissue lesions, proliferation of [[lymphocyte]]s ([[white blood cell]]s that fight infection), [[neutrophil]] [[granulocyte]]s (white blood cells involved with inflammation) and [[histiocyte|foamy histiocytes]] (tissue [[macrophage]]s) in the lung [[lumen]];<ref name=dpb06/><ref name=path/> detectable ''[[haemophilus influenzae]]'' (an [[opportunistic infection|opportunistic]] [[bacterium]]),<ref name=dpb06/> ''[[pseudomonas aeruginosa]]'' (another opportunistic bacterium) and [[pus]] in the [[sputum]] (coughed-up [[phlegm]]);<ref name=dpb/><ref name=path/> [[chronic sinusitis]] (inflamed [[paranasal sinus]]es),<ref name=lat/><ref name=usa/> [[hypoxemia]] (low levels of [[oxygen]] in the [[blood]]),<ref name=rep>{{cite journal |author=Chu YC, Yeh SZ, Chen CL, Chen CY, Chang CY, Chiang CD |title=Diffuse panbronchiolitis: report of a case |journal=J Formos Med Assoc. |volume=91 |issue=9 |pages=912-915 |year=1992 |pmid=1363394 }}</ref> nodules within [[terminal bronchiole|terminal]] and [[respiratory bronchiole]]s in both lungs,<ref name=thai/><ref name=can/> [[dyspnea]] (shortness of breath),<ref name=chitwo/><ref name=usa/> | These include: chronic [[bronchi]]al and bronchiolar inflammation, lung tissue lesions, proliferation of [[lymphocyte]]s ([[white blood cell]]s that fight infection), [[neutrophil]] [[granulocyte]]s (white blood cells involved with inflammation) and [[histiocyte|foamy histiocytes]] (tissue [[macrophage]]s) in the lung [[lumen]];<ref name=dpb06>{{cite journal |author=Poletti V, Casoni G, Chilosi M, Zompatori M |title=Diffuse panbronchiolitis |journal=Eur Respir J. |volume=28 |issue=4 |pages=862-871 |year=2006 |pmid=17012632 }}</ref> <ref name=path/> detectable ''[[haemophilus influenzae]]'' (an [[opportunistic infection|opportunistic]] [[bacterium]]),<ref name=dpb06>{{cite journal |author=Poletti V, Casoni G, Chilosi M, Zompatori M |title=Diffuse panbronchiolitis |journal=Eur Respir J. |volume=28 |issue=4 |pages=862-871 |year=2006 |pmid=17012632 }}</ref> ''[[pseudomonas aeruginosa]]'' (another opportunistic bacterium) and [[pus]] in the [[sputum]] (coughed-up [[phlegm]]);<ref name=dpb/><ref name=path/> [[chronic sinusitis]] (inflamed [[paranasal sinus]]es),<ref name=lat/><ref name=usa/> [[hypoxemia]] (low levels of [[oxygen]] in the [[blood]]),<ref name=rep>{{cite journal |author=Chu YC, Yeh SZ, Chen CL, Chen CY, Chang CY, Chiang CD |title=Diffuse panbronchiolitis: report of a case |journal=J Formos Med Assoc. |volume=91 |issue=9 |pages=912-915 |year=1992 |pmid=1363394 }}</ref> nodules within [[terminal bronchiole|terminal]] and [[respiratory bronchiole]]s in both lungs,<ref name=thai/><ref name=can/> [[dyspnea]] (shortness of breath),<ref name=chitwo/><ref name=usa/> | ||
elevated [[IgG]] and [[IgA]] (classes of [[immunoglobulin]]s),<ref name=chi/> occurrences of elevated [[rheumatoid factor]] (an indicator of [[autoimmunity]]),<ref name=chi/> and [[hemagglutination]] (clumping of [[antibodies]] in the blood).<ref name=chi/><ref name=cold>{{cite journal |author=Schulte W, Szrepka A, Bauer PC, Guzman J, Costabel U |title=Diffuse panbronchiolitis. A differential diagnosis of chronic obstructive lung disease |journal=Dtsch Med Wochenschr. |volume=124 |issue=19 |pages=584-588 |year=1999 |pmid=10365176 }}</ref> | elevated [[IgG]] and [[IgA]] (classes of [[immunoglobulin]]s),<ref name=chi/> occurrences of elevated [[rheumatoid factor]] (an indicator of [[autoimmunity]]),<ref name=chi/> and [[hemagglutination]] (clumping of [[antibodies]] in the blood).<ref name=chi/><ref name=cold>{{cite journal |author=Schulte W, Szrepka A, Bauer PC, Guzman J, Costabel U |title=Diffuse panbronchiolitis. A differential diagnosis of chronic obstructive lung disease |journal=Dtsch Med Wochenschr. |volume=124 |issue=19 |pages=584-588 |year=1999 |pmid=10365176 }}</ref> | ||
Revision as of 15:51, 24 September 2012
|
Diffuse panbronchiolitis Microchapters |
|
Differentiating Diffuse panbronchiolitis from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Diffuse panbronchiolitis history and symptoms On the Web |
|
American Roentgen Ray Society Images of Diffuse panbronchiolitis history and symptoms |
|
Risk calculators and risk factors for Diffuse panbronchiolitis history and symptoms |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Symptoms
DPB can be characterized by a number of symptoms and histological features (those detected by analysis of tissues).
These include: chronic bronchial and bronchiolar inflammation, lung tissue lesions, proliferation of lymphocytes (white blood cells that fight infection), neutrophil granulocytes (white blood cells involved with inflammation) and foamy histiocytes (tissue macrophages) in the lung lumen;[1] [2] detectable haemophilus influenzae (an opportunistic bacterium),[1] pseudomonas aeruginosa (another opportunistic bacterium) and pus in the sputum (coughed-up phlegm);[3][2] chronic sinusitis (inflamed paranasal sinuses),[4][5] hypoxemia (low levels of oxygen in the blood),[6] nodules within terminal and respiratory bronchioles in both lungs,[7][8] dyspnea (shortness of breath),[9][5] elevated IgG and IgA (classes of immunoglobulins),[10] occurrences of elevated rheumatoid factor (an indicator of autoimmunity),[10] and hemagglutination (clumping of antibodies in the blood).[10][11]
If left untreated, as DPB progresses, signs of bronchiectasis begin to present themselves. These symptoms include chronic shortness of breath, severe cough, pooling of sputum, thickening of bronchiolar walls, hypoxemia, and dilation (enlargement) of the bronchiolar passages.[3][5] This eventually becomes life-threatening, leading to respiratory failure.[3]
References
- ↑ 1.0 1.1 Poletti V, Casoni G, Chilosi M, Zompatori M (2006). "Diffuse panbronchiolitis". Eur Respir J. 28 (4): 862–871. PMID 17012632.
- ↑ 2.0 2.1
- ↑ 3.0 3.1 3.2
- ↑
- ↑ 5.0 5.1 5.2
- ↑ Chu YC, Yeh SZ, Chen CL, Chen CY, Chang CY, Chiang CD (1992). "Diffuse panbronchiolitis: report of a case". J Formos Med Assoc. 91 (9): 912–915. PMID 1363394.
- ↑
- ↑
- ↑
- ↑ 10.0 10.1 10.2
- ↑ Schulte W, Szrepka A, Bauer PC, Guzman J, Costabel U (1999). "Diffuse panbronchiolitis. A differential diagnosis of chronic obstructive lung disease". Dtsch Med Wochenschr. 124 (19): 584–588. PMID 10365176.