Post-streptococcal glomerulonephritis: Difference between revisions
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==External links== | ==External links== | ||
*[http://www.niaid.nih.gov/factsheets/strep.htm Group A Streptococcal Infections] - [[National Institute of Allergy and Infectious Diseases]] | *[http://www.niaid.nih.gov/factsheets/strep.htm Group A Streptococcal Infections] - [[National Institute of Allergy and Infectious Diseases]] | ||
{{Nephrology}} | {{Nephrology}} | ||
[[Category:Kidney diseases]] | [[Category:Kidney diseases]] | ||
Revision as of 16:51, 27 September 2012
| Post-streptococcal glomerulonephritis | |
| ICD-9 | 580.0 |
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| DiseasesDB | 29306 |
| MedlinePlus | 000503 |
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Post-streptococcal glomerulonephritis Microchapters |
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Differentiating Post-streptococcal glomerulonephritis from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Post-streptococcal glomerulonephritis On the Web |
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American Roentgen Ray Society Images of Post-streptococcal glomerulonephritis |
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Directions to Hospitals Treating Post-streptococcal glomerulonephritis |
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Risk calculators and risk factors for Post-streptococcal glomerulonephritis |
For patient information click here
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords:: [[Acute proliferative glomerulonephritis]]; post-infectious glomerulonephritis
Overview
Pathophysiology
Causes
Differentiating Post-streptococcal glomerulonephritis from other Diseases
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Criteria | History and Symptoms | Physical Examination | Laboratory Findings | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies
Treatment
Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies
Case Studies
In nephrology, post-streptococcal glomerulonephritis is a disorder of the glomeruli (glomerulonephritis), or small blood vessels in the kidneys, following an streptococci infection. This condition is essentially defined as an inflammation of the kidneys.
A closely related term is "post-infectious glomerulonephritis", which accounts for infections by other agents. However, this term is used much less frequently.
Pathophysiology
The exact pathology remains unclear, but it is believed to be Type III hypersensitivity reaction. Immune complexes (antigen-antibody complexes formed during an infection) become lodged in the glomerular basement membrane. Complement activation leads to destruction of the basement membrane. It has also been proposed that specific antigens from certain nephrotoxic streptococcal infections have a high affinity for basement membrane proteins, giving rise to particularly severe, long lasting antibody response.
Presentation
Patients will present with acute nephritic syndrome, with the pentad of hypertension, decrease in glomerular filtration rate, hematuria, proteinuria and fluid retention.
Causes
Post-infectious glomerulonephritis can be a complication of streptococcal pharyngitis (strep throat).
Diagnosis
Diagnosis rarely requires a renal biopsy since there is usually a classical clinical presentation. There will be elevated levels of ASOT Ab and low complement levels in the blood.