Lupus nephritis natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
==Natural History, Complications and Prognosis== | |||
===Natural History=== | |||
[[Lupus nephritis]] may damage different parts of the kidney. Class I has normal histology and does not show any evidence of disease and class V shows an extensive disease. | |||
===Complications=== | |||
Possible complications include: | |||
* Interstitial nephritis | |||
* [[Nephrotic syndrome]] | |||
* [[Membranous glomerulonephritis]] | |||
* [[Kidney failure]] - acute and chronic | |||
* [[End stage renal disease]] | |||
===Prognosis=== | |||
* The class of lupus nephritis: [[Focal lupus nephritis]], [[minimal mesangial lupus nephritis]] and [[mesangial proliferative lupus nephritis]] have better prognosis than other classes. And, [[advanced sclerosis lupus nephritis]] carries a poor prognosis. | |||
* Nephrotic syndrome carries worse prognosis. | |||
* Creatinine level: Patients with elevated [[creatinine]] (>3 mg/dL) at presentation have worse outcomes. | |||
* Patients with persistently elevated [[anti-dsDNA]] and low C3 and C4 levels have poorer outcomes. | |||
* Renal [[biopsy]] findings showing diffuse lupus nephritis or high chronicity index suggest worse prognosis. | |||
* Young age onset carries worse prognosis. | |||
* Male gender have poorer outcomes than female. | |||
* Black race have worse outcomes than other races. | |||
* Although lupus nephritis may return in a transplanted kidney, it rarely leads to [[end-stage kidney disease]]. | |||
==References== | ==References== | ||
Revision as of 13:46, 28 September 2012
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Lupus nephritis Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Lupus nephritis natural history, complications and prognosis On the Web |
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Risk calculators and risk factors for Lupus nephritis natural history, complications and prognosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2], Raviteja Guddeti, M.B.B.S. [3]
Overview
Natural History, Complications and Prognosis
Natural History
Lupus nephritis may damage different parts of the kidney. Class I has normal histology and does not show any evidence of disease and class V shows an extensive disease.
Complications
Possible complications include:
- Interstitial nephritis
- Nephrotic syndrome
- Membranous glomerulonephritis
- Kidney failure - acute and chronic
- End stage renal disease
Prognosis
- The class of lupus nephritis: Focal lupus nephritis, minimal mesangial lupus nephritis and mesangial proliferative lupus nephritis have better prognosis than other classes. And, advanced sclerosis lupus nephritis carries a poor prognosis.
- Nephrotic syndrome carries worse prognosis.
- Creatinine level: Patients with elevated creatinine (>3 mg/dL) at presentation have worse outcomes.
- Patients with persistently elevated anti-dsDNA and low C3 and C4 levels have poorer outcomes.
- Renal biopsy findings showing diffuse lupus nephritis or high chronicity index suggest worse prognosis.
- Young age onset carries worse prognosis.
- Male gender have poorer outcomes than female.
- Black race have worse outcomes than other races.
- Although lupus nephritis may return in a transplanted kidney, it rarely leads to end-stage kidney disease.