Membranoproliferative glomerulonephritis overview

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Membranoproliferative glomerulonephritis or MPGN is a type of glomerulonephritis caused by immune complexes depositing in the kidney glomerular mesangium and basement membrane (GBM), activating complement and damaging the glomeruli. The GBM is rebuilt ontop of the deposits, causing a "tram-tracking" appearance under the microscope.