Acute liver failure overview: Difference between revisions
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'''Acute liver failure''' is the appearance of severe complications rapidly after the first signs of liver disease (such as [[jaundice]]), and indicates that the liver has sustained severe damage (loss of function of 80-90% of liver cells). The complications are [[hepatic encephalopathy]] and impaired [[protein synthesis]] (as measured by the levels of [[serum albumin]] and the [[prothrombin time]] in the blood). | '''Acute liver failure''' is the appearance of severe complications rapidly after the first signs of liver disease (such as [[jaundice]]), and indicates that the liver has sustained severe damage (loss of function of 80-90% of liver cells). The complications are [[hepatic encephalopathy]] and impaired [[protein synthesis]] (as measured by the levels of [[serum albumin]] and the [[prothrombin time]] in the blood). | ||
'''Definition : ''' Evidence of coagulation abnormality, usually an International Normalized Ratio (INR) | '''Definition : ''' Evidence of coagulation abnormality, usually an International Normalized Ratio (INR) > 1.5, and any degree of mental alteration (encephalopathy) in a patient without preexisting cirrhosis and with an illness of <26 weeks duration. <ref name="pmid4908702">{{cite journal |author=Trey C, Davidson CS |title=The management of fulminant hepatic failure |journal=[[Progress in Liver Diseases]] |volume=3 |issue= |pages=282–98 |year=1970 |pmid=4908702 |doi= |url= |accessdate=2012-10-25}}</ref> | ||
==References== | ==References== | ||
Revision as of 05:58, 26 October 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Acute liver failure is the appearance of severe complications rapidly after the first signs of liver disease (such as jaundice), and indicates that the liver has sustained severe damage (loss of function of 80-90% of liver cells). The complications are hepatic encephalopathy and impaired protein synthesis (as measured by the levels of serum albumin and the prothrombin time in the blood).
Definition : Evidence of coagulation abnormality, usually an International Normalized Ratio (INR) > 1.5, and any degree of mental alteration (encephalopathy) in a patient without preexisting cirrhosis and with an illness of <26 weeks duration. [1]
References
- ↑ Trey C, Davidson CS (1970). "The management of fulminant hepatic failure". Progress in Liver Diseases. 3: 282–98. PMID 4908702.
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