Acute liver failure classification: Difference between revisions
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The 1993 classification defines <ref>O'Grady JG, Schalm SW, Williams R. Acute liver failure: redefining the syndromes. ''[[The Lancet|Lancet]] 1993;342:273-5. PMID 8101303.</ref> It reflects the fact that the pace of disease evolution strongly influence prognosis. Underlying [[aetiology]] is the other significant determinant of outcome.<ref name="ogredy1">{{cite journal |author=O'Grady JG |title=Acute liver failure |journal=Postgraduate medical journal |volume=81 |issue=953 |pages=148-54 |year=2005 |pmid=15749789 |doi=10.1136/pgmj.2004.026005}}</ref> It is based upon the duration between onset of jaundice to onset of encephalopathy. | The 1993 classification defines <ref>O'Grady JG, Schalm SW, Williams R. Acute liver failure: redefining the syndromes. ''[[The Lancet|Lancet]] 1993;342:273-5. PMID 8101303.</ref> It reflects the fact that the pace of disease evolution strongly influence prognosis. Underlying [[aetiology]] is the other significant determinant of outcome.<ref name="ogredy1">{{cite journal |author=O'Grady JG |title=Acute liver failure |journal=Postgraduate medical journal |volume=81 |issue=953 |pages=148-54 |year=2005 |pmid=15749789 |doi=10.1136/pgmj.2004.026005}}</ref> It is based upon the duration between onset of jaundice to onset of encephalopathy. | ||
{| | |||
! Time ! Classification | |||
|- | |||
| 1 week || Hyperacute | |||
|- | |||
| 1 week - 1 month || Acute | |||
|- | |||
| 1 week - 3 months || Subacute | |||
|} | |||
Hyperacute as within 1 week, | |||
* Acute as 8-28 days and | * Acute as 8-28 days and | ||
* Subacute as 4-12 weeks | * Subacute as 4-12 weeks | ||
Revision as of 01:33, 27 October 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2]
Overview
Acute liver failure is classified into hyperacute , acute and subacute depending upon the time lapsed between appearance of jaundice to encephalopathy. It is also classified into fulminant an subfulminant basing upon the time lapsed from start if illness to onset of encephalopathy.
Classification
The 1993 classification defines [1] It reflects the fact that the pace of disease evolution strongly influence prognosis. Underlying aetiology is the other significant determinant of outcome.[2] It is based upon the duration between onset of jaundice to onset of encephalopathy.
| Time ! Classification | |
|---|---|
| 1 week | Hyperacute |
| 1 week - 1 month | Acute |
| 1 week - 3 months | Subacute |
Hyperacute as within 1 week,
- Acute as 8-28 days and
- Subacute as 4-12 weeks
Acute liver failure can be classified into fulminant or subfulminant. Both the forms have poor prognosis. It is based upon the duration between onset of hepatic illness to development of encephalopathy.
- Fulminant hepatic failure - Development of hepatic encephalopathy within 2 months after the onset of acute liver disease.
- Subfulminant hepatic failure - Development of hepatic encephalopathy within 2 months to 6 months after the onset of acute liver disease