Congenital syphilis differential diagnosis: Difference between revisions

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{{Congenital syphilis}}
{{Congenital syphilis}}
==Overview==
Congenital syphilis must be differentiated from the TORCH infections.
==Differential Diagnosis==
The most important congenital infections, which can be transmitted vertically from mother to fetus are the [[TORCH infections]]. These infections have overlapping features and hence, must be differentiated from congenital syphilis :<ref name="pmid25677998">{{cite journal |vauthors=Neu N, Duchon J, Zachariah P |title=TORCH infections |journal=Clin Perinatol |volume=42 |issue=1 |pages=77–103, viii |year=2015 |pmid=25677998 |doi=10.1016/j.clp.2014.11.001 |url=}}</ref><ref name="pmid25654000">{{cite journal |vauthors=Ajij M, Nangia S, Dubey BS |title=Congenital rubella syndrome with blueberry muffin lesions and extensive metaphysitis |journal=J Clin Diagn Res |volume=8 |issue=12 |pages=PD03–4 |year=2014 |pmid=25654000 |pmc=4316306 |doi=10.7860/JCDR/2014/10271.5293 |url=}}</ref>
{| class="wikitable"
!Congenital Infection
!Cardiac Findings
!Skin Findings
!Ocular Findings
!Hepatosplenomegaly
!Hydrocephalus
!Microcephaly
!Intracranial Calcifications
!Hearing deficits
|-
![[Toxoplasmosis congenital|Toxoplasmosis]]
|
|
* [[Petechiae]]
* [[Purpura]]
* [[Maculopapular rash]]
|
* [[Chorioretinitis]]
|✔
|✔
|✔
|Diffuse intracranial calcifications
|
|-
![[Congenital Syphils]]
|
|
* [[Petechiae]]
* [[Purpura]]
* [[Maculopapular rash]]
|
* [[Chorioretinitis]]
* [[Glaucoma]]
|✔
|
|
|
|
|-
![[Rubella, congenital|Rubella]]
|
* [[Patent ductus arteriosus (PDA)]]
* [[Pulmonary artery stenosis]]
* [[Coarctation of the aorta]]
* [[Myocarditis]]
|
* [[Petechiae]]
* [[Purpura]]
|
* [[Chorioretinitis]]
* [[Cataracts]]
* [[Glaucoma]]
* [[Microphthalmia]]
|✔
|✔
|✔
|
|✔
|-
![[Cytomegalovirus (CMV)]]
|✔
|
* [[Petechiae]]
* [[Purpura]]
|
* [[Chorioretinitis]]
|✔
|
|✔
|Periventricular calcifications
|✔
|-
![[Herpes simplex virus (HSV)]]
|
* [[Myocarditis]]
|
* [[Petechiae]]
* [[Purpura]]
* [[Vesicles]]
|
* [[Chorioretinitis]]
|✔
|✔
|✔
|
|✔
|-
![[Parvovirus B19]]
|
* [[Myocarditis]]
|
* [[Petechiae]]
* [[Subcutaneous]] [[edema]]
|
* [[Chorioretinitis]]
* [[Cataracts]]
|✔
|
|
|
|
|}
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}

Revision as of 18:15, 15 February 2017

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Overview

Congenital syphilis must be differentiated from the TORCH infections.

Differential Diagnosis

The most important congenital infections, which can be transmitted vertically from mother to fetus are the TORCH infections. These infections have overlapping features and hence, must be differentiated from congenital syphilis :[1][2]

Congenital Infection Cardiac Findings Skin Findings Ocular Findings Hepatosplenomegaly Hydrocephalus Microcephaly Intracranial Calcifications Hearing deficits
Toxoplasmosis ✔ ✔ ✔ Diffuse intracranial calcifications
Congenital Syphils ✔
Rubella ✔ ✔ ✔ ✔
Cytomegalovirus (CMV) ✔ ✔ ✔ Periventricular calcifications ✔
Herpes simplex virus (HSV) ✔ ✔ ✔ ✔
Parvovirus B19 ✔

References

  1. ↑ Neu N, Duchon J, Zachariah P (2015). "TORCH infections". Clin Perinatol. 42 (1): 77–103, viii. doi:10.1016/j.clp.2014.11.001. PMID 25677998.
  2. ↑ Ajij M, Nangia S, Dubey BS (2014). "Congenital rubella syndrome with blueberry muffin lesions and extensive metaphysitis". J Clin Diagn Res. 8 (12): PD03–4. doi:10.7860/JCDR/2014/10271.5293. PMC 4316306. PMID 25654000.

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