Autoimmune hepatitis medical therapy: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
Line 5: | Line 5: | ||
Please help WikiDoc by adding more content here. It's easy! Click [[Help:How_to_Edit_a_Page|here]] to learn about editing. | Please help WikiDoc by adding more content here. It's easy! Click [[Help:How_to_Edit_a_Page|here]] to learn about editing. | ||
== Acute Pharmacotherapies == | ==Medical Therapy== | ||
=== Acute Pharmacotherapies === | |||
* Despite our clear understanding of the pathogenesis and pathophysiology of AH, approximately 80 % of patients will have a good initial response to corticosteroids, with a ten-year survival rate approaching 90%. | * Despite our clear understanding of the pathogenesis and pathophysiology of AH, approximately 80 % of patients will have a good initial response to corticosteroids, with a ten-year survival rate approaching 90%. | ||
* The decision to treat patients with only mild disease is often based on symptoms. | * The decision to treat patients with only mild disease is often based on symptoms. | ||
Line 16: | Line 17: | ||
* There are no firm guidelines concerning the tapering or discontinuation of therapy. | * There are no firm guidelines concerning the tapering or discontinuation of therapy. | ||
==Recommendations for the | ==Recommendations for the Treatment of Autoimmune Hepatitis (DO NOT EDIT)== | ||
{{cquote| | {{cquote| | ||
# Immunosuppressive treatment based on serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), serum gamma-globulin levels, and histological features | # Immunosuppressive treatment based on serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), serum gamma-globulin levels, and histological features | ||
Line 36: | Line 37: | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Gastroenterology]] | [[Category:Gastroenterology]] | ||
[[Category:Autoimmune Disease]] | |||
[[Category:Needs overview]] | [[Category:Needs overview]] |
Revision as of 18:43, 27 February 2013
Autoimmune hepatitis Microchapters |
Diagnosis |
---|
Treatment |
Case Studies |
Autoimmune hepatitis medical therapy On the Web |
American Roentgen Ray Society Images of Autoimmune hepatitis medical therapy |
Risk calculators and risk factors for Autoimmune hepatitis medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Please help WikiDoc by adding more content here. It's easy! Click here to learn about editing.
Medical Therapy
Acute Pharmacotherapies
- Despite our clear understanding of the pathogenesis and pathophysiology of AH, approximately 80 % of patients will have a good initial response to corticosteroids, with a ten-year survival rate approaching 90%.
- The decision to treat patients with only mild disease is often based on symptoms.
- Asymptomatic patients with mild inflammation on Bx can be observed with careful monitoring of histology.
- The goal of therapy is generally normalization of both transaminases and histology, and in general, most patients who are going to respond do so by 6 months.
- Unfortunately, the results with alternate-day or pulsed steroid regimens have been disappointing and daily regimens are preferred.
- Azathioprine can be used as a steroid-sparing agent.
- Additionally, some authors recommend using lower prednisone doses with the goal of partial suppression of disease, as opposed to higher doses of steroids with the goal being remission.
- For the 10 – 20% of patients who develop progressive disease despite steroids and/or azathioprine, cyclosporine and tacrolimus have recently been shown to induce remission.
- There are no firm guidelines concerning the tapering or discontinuation of therapy.
Recommendations for the Treatment of Autoimmune Hepatitis (DO NOT EDIT)
“ |
|
” |