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| __NOTOC__ | | __NOTOC__ |
| {{Creutzfeldt-Jakob disease}} | | {{Creutzfeldt-Jakob disease}} |
| {{CMG}}
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| ==Overview==
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| ==Medical Therapy==
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| As of 2007, there is no cure for CJD, a fatal disease, and the search for viable treatments continues. An experimental treatment was given to a Northern Irish teenager, [[Jonathan Simms]], beginning in January 2003.<ref>{{cite web | title =Teenager with vCJD 'stable'' | publisher = BBC News | date = [[13 December]][[2004]] | url = http://news.bbc.co.uk/2/hi/uk_news/northern_ireland/4092363.stm | accessdate = 2007-01-01 }}</ref> The medication, called [[pentosan polysulphate]] (PPS) and used to treat [[interstitial cystitis]], is infused into the patient's [[ventricular system|lateral ventricle]] within the brain. PPS does not seem to stop the disease from progressing, and both brain function and tissue continue to be lost. However, the treatment is alleged to slow the progression of the otherwise untreatable disease, and may have contributed to the longer than expected survival of the seven patients that were studied.<ref>{{cite web
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| | last = Bone | first = Ian | title =Intraventricular Pentosan Polysulphate in Human Prion Diseases: A study of Experience in the United Kingdom | publisher = Medical Research Council | date = [[12 July]] [[2006]] | url = http://www.mrc.ac.uk/NewsViewsAndEvents/News/MRC001707 | accessdate = 2007-01-01 }}</ref> The CJD Therapy Advisory Group to the UK Health Departments advises that data are not sufficient to support claims that [[pentosan polysulphate]] is an effective treatment and suggests that further research in animal models is appropriate.<ref>{{cite web|title=Use of Pentosan Polysulphate in the treatment of, or prevention of, vCJD|url = http://www.dh.gov.uk/en/Policyandguidance/Healthandsocialcaretopics/CJD/CJDgeneralinformation/DH_4031039|publisher= Department of Health:CJD Therapy Advisory Group| accessdate = 2007-10-30}}</ref> A 2007 review of the treatment of 26 patients with PPS finds no proof of efficacy because of the lack of accepted objective criteria.<ref>{{cite journal |author=Rainov NG, Tsuboi Y, Krolak-Salmon P, Vighetto A, Doh-Ura K |title=Experimental treatments for human transmissible spongiform encephalopathies: is there a role for pentosan polysulfate? |journal=Expert opinion on biological therapy |volume=7 |issue=5 |pages=713-26 |year=2007|pmid=17477808 |doi=10.1517/14712598.7.5.713}}</ref> | |
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| Scientists have investigated using [[RNA interference]] to slow the progression of [[scrapie]] in mice. The RNA blocks production of the protein that the CJD process transforms into [[prion]]s. This research is unlikely to lead to a human therapy for many years.<ref>{{cite web | title =Revamp of brain 'could slow CJD' |publisher = BBC News | date = [[4 December]] [[2006]] | url = http://news.bbc.co.uk/2/hi/health/6198072.stm | accessdate = 2007-01-01 }}</ref>
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| ==References== | | ==References== |
| {{Reflist|2}} | | {{Reflist|2}} |
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| [[Category:Transmissible spongiform encephalopathies]] | | [[Category:Transmissible spongiform encephalopathies]] |
| [[Category:Needs overview]] | | [[Category:Needs overview]] |
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