Chancroid pathophysiology: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Chancroid}} | {{Chancroid}} | ||
{{CMG}}; {{AE}} {{YD}}; {{NRM}}; {{SSK}} | |||
==Overview== | |||
==Pathophysiology== | |||
===Transmission=== | |||
Chancroid may develop after transmission of the bacterium ''Haemophilus ducreyi'' through sexual contact.<ref name="ChancroidMedlinePlus">Chancroid. MedlinePlus (Decemner 2, 2015). https://www.nlm.nih.gov/medlineplus/ency/article/000635.htm Accessed January 6, 2015.</ref> | |||
===Pathogenesis=== | |||
*''H. ducreyi'' enters skin through microabrasions incurred during sexual intercourse. | |||
*''H. ducreyi'' is thought to bind with epithelial cells and then colonize in the subcutaneous tissue.<ref name="pmid1391058">{{cite journal| author=Abeck D, Johnson AP| title=Pathophysiological concept of Haemophilus ducreyi infection (chancroid) | journal=Int J STD AIDS | year= 1992 | volume= 3 | issue= 5 | pages= 319-23 | pmid=1391058 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1391058}}</ref> | |||
*''H. ducreyi'' is then presumed to react predominantly with B cell and some T cell markers, which may lead to development of 1 or more erythematous papules. The papule(s) may progress into pustule(s) after further bacterial growth.<ref name="pmid1391058"></ref><ref name="ChancroidWikipedia">Chancroid. Wikipedia (July 16, 2015). https://en.wikipedia.org/wiki/Chancroid Accessed on January 6, 2016.</ref> | |||
*Ulcers develop after pustules undergo necrosis.<ref name="ChancroidWikipedia"></ref> The pathogenesis of ulceration is not fully understood but may involve release of toxic products by ''H. ducreyi'' on bacterial-induced inflamation.<ref name="pmid1391058"></ref> | |||
**Potential ''H. ducreyi'' by-products include: | |||
***Phospholipase C | |||
***Protease | |||
***Elastase | |||
***Lecithinase | |||
***Lipase | |||
***Collagenase | |||
*It is presumed that iron plays an essential role in chancroid pathogenesis.<ref name="pmid1391058"></ref> | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Sexually transmitted diseases]] | [[Category:Sexually transmitted diseases]] | ||
Revision as of 20:49, 6 January 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.; Nate Michalak, B.A.; Serge Korjian M.D.
Overview
Pathophysiology
Transmission
Chancroid may develop after transmission of the bacterium Haemophilus ducreyi through sexual contact.[1]
Pathogenesis
- H. ducreyi enters skin through microabrasions incurred during sexual intercourse.
- H. ducreyi is thought to bind with epithelial cells and then colonize in the subcutaneous tissue.[2]
- H. ducreyi is then presumed to react predominantly with B cell and some T cell markers, which may lead to development of 1 or more erythematous papules. The papule(s) may progress into pustule(s) after further bacterial growth.[2][3]
- Ulcers develop after pustules undergo necrosis.[3] The pathogenesis of ulceration is not fully understood but may involve release of toxic products by H. ducreyi on bacterial-induced inflamation.[2]
- Potential H. ducreyi by-products include:
- Phospholipase C
- Protease
- Elastase
- Lecithinase
- Lipase
- Collagenase
- Potential H. ducreyi by-products include:
- It is presumed that iron plays an essential role in chancroid pathogenesis.[2]
References
- ↑ Chancroid. MedlinePlus (Decemner 2, 2015). https://www.nlm.nih.gov/medlineplus/ency/article/000635.htm Accessed January 6, 2015.
- ↑ 2.0 2.1 2.2 2.3 Abeck D, Johnson AP (1992). "Pathophysiological concept of Haemophilus ducreyi infection (chancroid)". Int J STD AIDS. 3 (5): 319–23. PMID 1391058.
- ↑ 3.0 3.1 Chancroid. Wikipedia (July 16, 2015). https://en.wikipedia.org/wiki/Chancroid Accessed on January 6, 2016.