Creutzfeldt-Jakob disease other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Other Diagnostic Studies

Electroencephalography

Characteristic triphasic spikes

Biopsy

In one third of patients with sporadic CJD, deposits of prion protein (scrapie), PrP^Sc, can be found in the skeletal muscle and/or the spleen. Diagnosis of vCJD can be supported by biopsy of the tonsils, which harbour significant amounts of PrpSc; however, biopsy of brain tissue is the definitive diagnostic test.

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