Filariasis other diagnostic studies: Difference between revisions
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===PCR=== | ===PCR=== | ||
Molecular diagnosis using polymerase chain reaction is available for W. bancrofti and B. malayi. | Molecular diagnosis using [[polymerase chain reaction]] is available for [[W. bancrofti]] and [[B. malayi]]. | ||
===Biopsy=== | ===Biopsy=== | ||
Identification of adult worms is possible from tissue samples collected during nodulectomies (onchocerciasis), or during subcutaneous biopsies or worm removal from the eye (loiasis). | Identification of adult worms is possible from tissue samples collected during nodulectomies (onchocerciasis), or during subcutaneous biopsies or worm removal from the eye (loiasis). | ||
Revision as of 19:31, 2 January 2013
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Filariasis Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Other Diagnostic Studies
Antigen Detection
Antigen detection using an immunoassay for circulating filarial antigens constitutes a useful diagnostic approach, because microfilaremia can be low and variable. A rapid-format immunochromatographic test, applicable to Wuchereria bancrofti antigens, has been recently evaluated in the field.
PCR
Molecular diagnosis using polymerase chain reaction is available for W. bancrofti and B. malayi.
Biopsy
Identification of adult worms is possible from tissue samples collected during nodulectomies (onchocerciasis), or during subcutaneous biopsies or worm removal from the eye (loiasis).
Antibody Detection
Antibody detection is of limited value. Substantial antigenic cross reactivity exists between filaria and other helminths, and a positive serologic test does not distinguish between past and current infection.