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[[Rudolf Virchow]] noted several factors affecting the clot formation, which are as follows:
[[Rudolf Virchow]] noted several factors affecting the clot formation, which are as follows:


'''1).Alterations in blood flow ([[stasis]])''' : Blood flows throughout the circulatory system, without significantly stopping or slowing any where. In certain pathological conditions where the blood flow slows down or stops, it causes  
1) Alterations in blood flow ([[stasis]]) : Blood flows throughout the circulatory system, without significantly stopping or slowing any where. In certain pathological conditions where the blood flow slows down or stops, it causes  
*a) Increase in platelet to endothelium contact
*a) Increase in platelet to endothelium contact
*b) Decrease the dilution of clotting factors
*b) Decrease the dilution of clotting factors
This increases the risk of clot formation and form microthrombi, which further grow and propagate.
This increases the risk of clot formation and form microthrombi, which further grow and propagate.


'''2).Injury to the vascular endothelium''' : Intrinsic or secondary to external trauma (Eg. catheterization) can cause [[Tunica intima|intimal]] damage and stimulates clot formation. See [[Coagulation]]
2) Injury to the vascular endothelium : Intrinsic or secondary to external trauma (Eg. catheterization) can cause [[Tunica intima|intimal]] damage and stimulates clot formation. See [[Coagulation]]


'''3).Alterations in the constitution of blood ([[hypercoagulability]])''' :It is the propensity to develop thrombosis due to an abnormality in the system of coagulation.  
3) Alterations in the constitution of blood ([[hypercoagulability]]) :It is the propensity to develop thrombosis due to an abnormality in the system of coagulation.  


These three conditions are collectively known as [[Virchow's triad]] and lead to intravascular [[coagulation]], forming a mass of [[red blood cell]]s, [[leukocyte]]s, and [[fibrin]].
These three conditions are collectively known as [[Virchow's triad]] and lead to intravascular [[coagulation]], forming a mass of [[red blood cell]]s, [[leukocyte]]s, and [[fibrin]].


'''This video explains the process of thrombosis'''
'''This video explains the process of thrombosis:'''


{{#ev:youtube|X_POCRsy7i4}}  
{{#ev:youtube|X_POCRsy7i4}}  

Revision as of 15:42, 27 February 2013

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editors-in-Chief: Ujjwal Rastogi, MBBS [2]

Causes

Rudolf Virchow noted several factors affecting the clot formation, which are as follows:

1) Alterations in blood flow (stasis) : Blood flows throughout the circulatory system, without significantly stopping or slowing any where. In certain pathological conditions where the blood flow slows down or stops, it causes

  • a) Increase in platelet to endothelium contact
  • b) Decrease the dilution of clotting factors

This increases the risk of clot formation and form microthrombi, which further grow and propagate.

2) Injury to the vascular endothelium : Intrinsic or secondary to external trauma (Eg. catheterization) can cause intimal damage and stimulates clot formation. See Coagulation

3) Alterations in the constitution of blood (hypercoagulability) :It is the propensity to develop thrombosis due to an abnormality in the system of coagulation.

These three conditions are collectively known as Virchow's triad and lead to intravascular coagulation, forming a mass of red blood cells, leukocytes, and fibrin.

This video explains the process of thrombosis:

{{#ev:youtube|X_POCRsy7i4}}


Other Causes

High altitude [1], has also been known to induce thrombosis Occasionally, abnormalities in coagulation are to blame.

References

  1. Kuipers S, Cannegieter SC, Middeldorp S, Robyn L, Büller HR, Rosendaal FR (2007). "The absolute risk of venous thrombosis after air travel: a cohort study of 8,755 employees of international organisations". PLoS Med. 4 (9): e290. doi:10.1371/journal.pmed.0040290. PMC 1989755. PMID 17896862.


cs:Trombóza de:Thrombose eo:Trombozo it:Trombosi he:תרומבוס ms:Trombotik nl:Trombose fi:Verihiutale

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