Lactic acidosis overview: Difference between revisions
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The cells produce lactic acid when they use [[glucose]] for energy in the absence of adequate [[oxygen]]. If too much lactic acid stays in the body, the balance tips and the person begins to feel ill. The signs of lactic acidosis are deep and rapid breathing, vomiting, and abdominal pain. Lactic acidosis may be caused by [[diabetic ketoacidosis]] or [[liver]] or [[kidney]] disease, as well as some forms of medication (most notably the anti-diabetic drug [[metformin]]). Some anti-HIV drugs ([[antiretroviral]]s) warn doctors in their prescribing information to regularly watch for symptoms of lactic acidosis caused by [[mitochondrial toxicity]]. | The cells produce lactic acid when they use [[glucose]] for energy in the absence of adequate [[oxygen]]. If too much lactic acid stays in the body, the balance tips and the person begins to feel ill. The signs of lactic acidosis are deep and rapid breathing, vomiting, and abdominal pain. Lactic acidosis may be caused by [[diabetic ketoacidosis]] or [[liver]] or [[kidney]] disease, as well as some forms of medication (most notably the anti-diabetic drug [[metformin]]). Some anti-HIV drugs ([[antiretroviral]]s) warn doctors in their prescribing information to regularly watch for symptoms of lactic acidosis caused by [[mitochondrial toxicity]]. | ||
==Diagnosis== | |||
{| | |||
|-style="background:silver; color:black" | |||
| '''Reference Range''' || | |||
|-style="background:silver; color:black" | |||
| '''Capillary Blood''' || '''5-15 mg/dl''' | |||
|- style="background:silver; color:black" | |||
| '''Deoxygenated Blood''' || '''-16 mg/dl''' | |||
|-style="background:silver; color:black" | |||
| '''Cerebrospinal Fluid (CSF)''' || '''11-19 mg/dl''' | |||
|} | |||
==Treatment== | ==Treatment== | ||
===Medical Therapy=== | ===Medical Therapy=== | ||
Revision as of 12:13, 17 July 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Lactic acidosis is a condition caused by the buildup of lactic acid in the body. It leads to acidification of the blood (acidosis), and is considered a distinct form of metabolic acidosis.
The cells produce lactic acid when they use glucose for energy in the absence of adequate oxygen. If too much lactic acid stays in the body, the balance tips and the person begins to feel ill. The signs of lactic acidosis are deep and rapid breathing, vomiting, and abdominal pain. Lactic acidosis may be caused by diabetic ketoacidosis or liver or kidney disease, as well as some forms of medication (most notably the anti-diabetic drug metformin). Some anti-HIV drugs (antiretrovirals) warn doctors in their prescribing information to regularly watch for symptoms of lactic acidosis caused by mitochondrial toxicity.
Diagnosis
| Reference Range | |
| Capillary Blood | 5-15 mg/dl |
| Deoxygenated Blood | -16 mg/dl |
| Cerebrospinal Fluid (CSF) | 11-19 mg/dl |
Treatment
Medical Therapy
The main treatment for lactic acidosis is to correct the medical problem that causes the condition.