Heartburn differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Differentiating heartburn from other diseases

• Angina / ischemia
• Ascites
• Asthma
• Barrett's Esophagus
• Cardiotomy
• Caustic agent ingestion with resultant mucosal injury
• Chagas Disease
• Cholelithiasis
• Clothes (elevated internal stomach pressure)
• Constipation
• Coronary Artery Disease
• Coughing
• CREST syndrome (Calcinosis Raynaud's phenomenon Esophagus Sclerodactyly Telangiectasias)
• Direct irritation of esophagus:

Aspirin

Cigarette smoke

Citrus fruits, juice

Ibuprofen

Spicy foods

Tomatoes

Tomato sauce

• Diabetes
• Drugs:

Albuterol

Anticholinergics

Caffeine

Calcium channel blockers

Cigarette smoking

Nitrates

Progesterone

Theophylline

• Esophageal atresia or fistula
• Esophageal carcinoma
• Esophageal diverticulum
• Esophageal varices
• Foods:

Alcohol

Chocolate

Coffee

Fatty foods

Peppermint

Soft drinks with caffeine

Tea

• Fundectomy (postoperative)
• Gastrectomy (postoperative)
• Gastritis
• Gastroesophageal Reflux Disease (GERD)
• Hiatal hernia
• Infectious esophagitis
• Lifting
• Mallory-Weiss Tear
• Motility disorders
• Muscle strain
• Myasthenia gravis
• Myocardial Infarction
• Obesity
• Peptic Ulcer Disease
• Pericardial Disease
• Pregnancy
• Primary reflux esophagitis
• Pulmonary Embolism
• Raynaud's Phenomenon
• Scleroderma
• Strictures, webs or rings
• Vagotomy (postoperative)