Myasthenia gravis overview: Difference between revisions
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==Overview== | ==Overview== | ||
'''Myasthenia gravis''' (literally "serious muscle-weakness"; from [[Greek language|Greek]] ''μύς'' "muscle", {{polytonic|''ἀσθένεια''}} "weakness", and [[Latin]] ''gravis'' "serious"; | '''Myasthenia gravis''' (literally "serious muscle-weakness"; from [[Greek language|Greek]] ''μύς'' "muscle", {{polytonic|''ἀσθένεια''}} "weakness", and [[Latin]] ''gravis'' "serious"; abbreviated MG) is a [[neuromuscular disease]] leading to fluctuating muscle weakness and [[fatigue (physical)|fatiguability]]. It is an [[autoimmunity|autoimmune disorder]], in which weakness is caused by circulating [[antibody|antibodies]] that block [[acetylcholine receptor]]s at the post-synaptic [[neuromuscular junction]],<ref name=Conti-Fine>{{cite journal |author=Conti-Fine BM, Milani M, Kaminski HJ |title=Myasthenia gravis: past, present, and future |journal=J. Clin. Invest. |volume=116 |issue=11 |pages=2843-54 |year=2006 |pmid=17080188 |doi=10.1172/JCI29894}} {{PMC|1626141}}</ref> inhibiting the stimulative effect of the [[neurotransmitter]] [[acetylcholine]]. Myasthenia is treated medically with [[cholinesterase inhibitor]]s or [[immunosuppressants]] and in selected cases with [[thymectomy]]. At 200-400 cases per million it is one of the less common [[autoimmune disorder]]s.<ref name=Conti-Fine/> | ||
==References== | ==References== | ||
Revision as of 15:01, 9 July 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Myasthenia gravis (literally "serious muscle-weakness"; from Greek μύς "muscle", Template:Polytonic "weakness", and Latin gravis "serious"; abbreviated MG) is a neuromuscular disease leading to fluctuating muscle weakness and fatiguability. It is an autoimmune disorder, in which weakness is caused by circulating antibodies that block acetylcholine receptors at the post-synaptic neuromuscular junction,[1] inhibiting the stimulative effect of the neurotransmitter acetylcholine. Myasthenia is treated medically with cholinesterase inhibitors or immunosuppressants and in selected cases with thymectomy. At 200-400 cases per million it is one of the less common autoimmune disorders.[1]